Total synthesis of Zoanthamine

18.奖学金培训和职业目标我培训的主要目标是学习必要的技能，成为一名优秀的有机化学家，能够在大学一级教授有机化学，并能够独立进行研究。Theodorakis的实验室培育了新的想法，并鼓励开发有机合成的新方法。这种方法将提高我对化学反应的理解。Theodorakis小组每周举行的研究会议，每个学生都会对他们正在进行的研究进行彻底的解释，这将帮助我练习我的教学技能，并更好地理解化学。此外，为了更好地了解不同分子的生物作用方式，还不断讨论有机化学和生物学之间的相关性。这个项目将使我接触到实验室和课堂上取得成功所需的尽可能多的化学知识。这笔奖学金将使我能够实现我的职业目标，即完成我的博士学位，最终在大学一级任教，并为弱势少数群体树立榜样19。姓名和学位(S)伊曼纽尔·西奥多拉基斯，20。加州大学，圣21。研究方向/领域天然产物合成与药物设计22.描述(不超过所提供的篇幅)发起人有机化学博士学位迭戈有机化学教授I|_tl_；1“，‘ol”n-，，-i_’I_L我们的目标是开发一种可行的合成方法，能够以简明的方式产生Zoanthine和该生物碱家族的其他成员，如去甲基苯甲胺。这些生物碱大多具有高度官能化的反式十一酮和杂环氨基环体系，以及至少三个四元手性中心(花色胺的C-9、C-12、C-22)。在一个模型系统中，佐安他明及其类似物被发现能抑制佛波醇肉豆蔻酸酯引起的炎症。去甲苯甲胺对培养的P388小鼠白血病细胞有生长抑制作用。此外，去甲苯甲胺还能抑制IL-6的产生。最近，有报道称，黄嘌呤类生物碱可抑制骨重的下降。该核心的构建将引导我们开发一个类似物的文库，以进一步研究它们作为骨质疏松症药物和/或抗炎药物的候选药物的潜力。PHS 416-1(Rev.12/98)表第2页BB同名(最后、第一个、中间首字母)单个NRSA应用程序Rivas、Fatima、R页码(页码)通过应用程序D在底部连续页码。单一用途部分I-申请人后缀5a、5b。)首页(项目1-8、15)、表单页面2(项目16-18、22)和目录========================================Section End===========================================

18. GOALS FOR FELLOWSHIP TRAINING AND CAREER The primary goal for my training is to learn the necessary skills to become an excellent organic chemist who can teach organic chemistry at the university level and can conduct research independently. The Theodorakis' laboratory nurtures new ideas and encourages the development of new methodologies in organic synthesis. This approach will enhance my understanding chemical reactivity. The weekly research meetings of the Theodorakis' group during which every student presents a thorough explanation of their ongoing research will help me practice my teaching skills and to develop a better understanding of chemistry. In addition, the correlation between organic chemistry and biology is constantly discussed in order to better understand the biological mode of action of different molecules. This project will expose me to as much chemistry as needed to succeed in the laboratory as well as in the classroom. This fellowship would enable me to accomplish my career goals which are to complete my Ph. D to ultimately teach at the university level and set a role model to disadvantaged minority groups 19. NAME AND DEGREE(S) Emmanuel Theodorakis, 20. POSITION/RANK University of California, San 21. RESEARCH INTERESTS/AREAS Total Synthcsis of Natural Products and Drug Design 22. DESCRIPTION (Do not exceed space provided) SPONSOR Doctorate degree in Organic Chemistry Diego Organic Chemistry Professor i| _tl _;1 ",'ol"n -,,-Il_o]llo]-'_'i_l Our goal is to develop a feasible synthetic procedure that can yield Zoanthamine and other members of this alkaloid family such as norzoanthamine in a concise manner. Most of these alkaloids possess highly functionalized trans-decalone and heterocyclic aminal ring system along with at least three quaternary chiral centers (C-9, C-12, C-22 for zoanthamine). Zoanthamine and its relatives were found to inhibit phorbol myristate acetate induced inflammation in a model system. Norzoanthamine was found to inhibit the growth of P388 murine leukemia cell cultures. In addition, norzoanthamine inhibits IL-6 production. Recently, it has been reported that zoanthamine-type alkaloids suppress the decrease in bone weight. The construction of the core of zoanthamine will lead us to hopefully develop a library of its analogs to further study their potential as candidates for an osteoporotic drug and/or an anti-inflammatory drug. PHS 416-1 (Rev. 12/98) Form Page 2 BB co NAME(Last, first,middle initial) Individual NRSA Application Rivas, Fatima, R Tabte of Contents Page Numbers (Numberpagesconsecutively at thebottomthroughouthe applicationD. onotuse Section I-Applicant suffixesuchas5a, 5b.) Face Page (Items 1-8, 15), Form Page 2 (items 16-18, 22), and Table of Contents ========================================Section End===========================================