Study of Tritonia crawl circuit and ciliated motor cells

描述(由申请人提供)：常见的有节奏的运动行为，如行走、咀嚼和呼吸，由神经电路和中央模式发生器控制。最近的研究表明，单个神经回路可以重新配置，以控制两种完全不同的运动行为。海洋软体动物Tritonia diomedea具有良好的节律性运动模式，即逃逸游泳反应，证据表明逃逸游泳控制回路也可能控制非节律/非肌肉爬行行为。Tritonia diomedea的非肌肉爬行是以纤毛为基础的，因此为研究纤毛控制和协调机制提供了额外的机会。该提案代表着一个侧重于爬行马达系统的项目的开始，具体地说：描述负责协调马达输出/纤毛跳动的神经机制(目标一)和纤毛跳动控制的细胞机制(目标二)。这个项目的完成将详细描述神经系统如何控制纤毛行为，这是理解整个爬行运动系统的第一步。纤毛排列在脑室、气管和输卵管内，可以在神经控制下协调，而Tritonia提供了一个很好的机会来发现如何进行。该项目还可能有助于理解和治疗运动系统障碍，以及展示中枢神经系统如何控制非肌肉运动行为。

DESCRIPTION (provided by applicant): Common rhythmic motor behaviors such as walking, chewing, and breathing are controlled by neural circuits and central pattern generators. Recent studies show single neural circuits can be reconfigured to control two totally different motor behaviors. The marine mollusc Tritonia diomedea possesses a well described rhythmic motor pattern, the escape swim response, and evidence suggests the escape swim control circuit may also control the non-rhythmic/non- muscular crawling behavior. Tritonia diomedea's non- muscular crawling is cilia based and therefore offers the additional opportunity of studying the mechanisms for ciliary control and coordination. This proposal represents the beginnings of a project focusing on the crawling motor system, specifically: a characterization of the neural mechanism responsible for coordinating the motor output / cilia beating (Aim I) and the cellular machinery of cilia beating control (Aim II). The completion of this project will produce a detailed description of how a nervous system can control cilia behavior, the first step of understanding the entire crawling motor system. Cilia lining brain ventricles, airways, and oviducts may be coordinated under nervous control and Tritonia offers an excellent opportunity to discover how. This project may also contribute to the understanding and treatment of motor system disorders as well as demonstrate how the CNS may control non-muscular motor behaviors.