权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Study of Tritonia crawl circuit and ciliated motor cells

Tritonia爬行回路和纤毛运动细胞的研究

基本信息

批准号：
6963376
负责人：
OWEN M WOODWARD
金额：
$ 1.47万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-05 至 2005-12-04
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6963376
关键词：
Mollusca biological signal transduction calcium channel epithelium ethology foot immunocytochemistry invertebrate locomotion motor neurons neural information processing neuroanatomy neuropeptides neuroregulation neurotransmitters predoctoral investigator tissue /cell preparation voltage /patch clamp

项目摘要

DESCRIPTION (provided by applicant): Common rhythmic motor behaviors such as walking, chewing, and breathing are controlled by neural circuits and central pattern generators. Recent studies show single neural circuits can be reconfigured to control two totally different motor behaviors. The marine mollusc Tritonia diomedea possesses a well described rhythmic motor pattern, the escape swim response, and evidence suggests the escape swim control circuit may also control the non-rhythmic/non- muscular crawling behavior. Tritonia diomedea's non- muscular crawling is cilia based and therefore offers the additional opportunity of studying the mechanisms for ciliary control and coordination. This proposal represents the beginnings of a project focusing on the crawling motor system, specifically: a characterization of the neural mechanism responsible for coordinating the motor output / cilia beating (Aim I) and the cellular machinery of cilia beating control (Aim II). The completion of this project will produce a detailed description of how a nervous system can control cilia behavior, the first step of understanding the entire crawling motor system. Cilia lining brain ventricles, airways, and oviducts may be coordinated under nervous control and Tritonia offers an excellent opportunity to discover how. This project may also contribute to the understanding and treatment of motor system disorders as well as demonstrate how the CNS may control non-muscular motor behaviors.

描述（由申请人提供）：常见的节律性运动行为，如行走、咀嚼和呼吸，由神经回路和中枢模式发生器控制。最近的研究表明，单个神经回路可以重新配置，以控制两种完全不同的运动行为。海洋软体动物Tritonia diomedea具有一种很好描述的节律性运动模式，即逃避游泳反应，证据表明逃避游泳控制回路也可能控制非节律/非肌肉爬行行为。Tritonia diomedea的非肌肉爬行是基于纤毛的，因此提供了研究纤毛控制和协调机制的额外机会。该提案代表了一个专注于爬行运动系统的项目的开始，具体而言：负责协调运动输出/纤毛跳动（Aim I）和纤毛跳动控制（Aim II）的细胞机制的神经机制的表征。这个项目的完成将产生一个神经系统如何控制纤毛行为的详细描述，了解整个爬行运动系统的第一步。纤毛衬脑室，气道和输卵管可能是协调下的神经控制和Tritonia提供了一个很好的机会，发现如何。该项目也可能有助于理解和治疗运动系统疾病，以及证明中枢神经系统如何控制非肌肉运动行为。