Cell Culture and Engineering Core (CCEC)
细胞培养与工程核心 (CCEC)
基本信息
- 批准号:10231259
- 负责人:
- 金额:$ 18.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-24 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAcademiaAddressAffectAllelesAntibodiesAutosomal Dominant Polycystic KidneyBiological AssayCell Culture TechniquesCell LineCell NucleusCell modelCellsCellular AssayClinicalClinical DataCollaborationsCommunitiesConsultationsCoupledCustomCystCyst FluidDataDuct (organ) structureDuctal Epithelial CellEngineeringEnsureEnterobacteria phage P1 Cre recombinaseEpithelial CellsExperimental DesignsFutureGene ExpressionGene Expression ProfilingGoalsGoldGovernmentHumanIn VitroIndividualIndustryInvestigationKidneyKnock-outKnockout MiceLogisticsLoxP-flanked alleleMarylandMindModelingMusMutationOrganoidsPathway interactionsPatientsPhenotypePolycystic Kidney DiseasesPositioning AttributePreparationPrimary Cell CulturesProceduresProprotein Convertase 1Protocols documentationQuality ControlReproducibilityResearchResearch PersonnelResourcesServicesSiteSpecimenStretchingSystemTetracyclinesTherapeuticTimeTissuesTranslationsValidationcellular engineeringdesignfrontierhigh standardhigh throughput screeningin vitro Modelinnovationinterestkidney epithelial cellknock-downmutantnew technologyorganizational structurerenal epitheliumscreeningtherapeutic evaluationtranscriptome sequencingtreatment responsevalidation studiesvector
项目摘要
PROJECT SUMMARY
The Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC)
Cell Culture and Engineering Core (CCEC) will accelerate progress in PKD research by
addressing a major unmet need for well-defined, reliable in vitro cell PKD models with proper
controls. With this overarching goal in mind, CCEC developed new in vitro cell and organoid
models that we hope will become the “gold-standards” of the field. The CCEC is committed to
helping investigators find ideal solutions for all their individual in vitro research needs whether it
involves mechanistic exploration, human PKD cell validation studies, or therapeutic screening. To
best serve the current and expected future demands of the diverse PKD workforce in academia,
government, and industry, the CCEC will provide murine cell models of ADPKD, provide
engineered inner medullary collecting duct (IMCD3) cell lines expressing custom PKD1 and PKD2
mutations, provide human kidney ADPKD cells and specimens, provide a cutting edge
cystogenesis assay using three-dimensional organoid system, provide high through-put, three-
dimensional cyst expansion assay, and provide consultation services to make sure the PKD
community can fully utilize the CCEC resources.
项目摘要
马里兰州多囊肾病研究和翻译核心中心(MPKD-RTCC)
细胞培养和工程核心(CCEC)将加速PKD研究的进展,
解决了一个主要的未满足的需求,明确定义的,可靠的体外细胞PKD模型与适当的
对照考虑到这一总体目标,CCEC开发了新的体外细胞和类器官
我们希望这些模型将成为该领域的“黄金标准”。CCEC致力于
帮助研究人员找到理想的解决方案,以满足他们所有的体外研究需求,
涉及机制探索、人PKD细胞验证研究或治疗筛选。到
最好地服务于学术界多样化PKD劳动力的当前和预期未来需求,
CCEC将提供ADPKD的鼠细胞模型,
表达定制PKD 1和PKD 2的工程化内髓集合管(IMCD 3)细胞系
突变,提供人类肾脏ADPKD细胞和标本,提供前沿
使用三维类器官系统的囊生成测定,提供高通量、三维
三维囊肿扩张试验,并提供咨询服务,以确保PKD
社区可以充分利用CCEC资源。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
OWEN M WOODWARD其他文献
OWEN M WOODWARD的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('OWEN M WOODWARD', 18)}}的其他基金
Study of Tritonia crawl circuit and ciliated motor cells
Tritonia爬行回路和纤毛运动细胞的研究
- 批准号:
6832616 - 财政年份:2004
- 资助金额:
$ 18.33万 - 项目类别:
Study of Tritonia crawl circuit and ciliated motor cells
Tritonia爬行回路和纤毛运动细胞的研究
- 批准号:
6963376 - 财政年份:2004
- 资助金额:
$ 18.33万 - 项目类别:
相似海外基金
Conference: Rethinking how language background is described in academia and beyond
会议:重新思考学术界及其他领域如何描述语言背景
- 批准号:
2335912 - 财政年份:2024
- 资助金额:
$ 18.33万 - 项目类别:
Standard Grant
ADVANCE Catalyst: Virtual Observatory of Culture for Equity in Academia at the University of Puerto Rico Rio Piedras (VoCEA)
ADVANCE Catalyst:波多黎各 Rio Piedras 大学学术界平等文化虚拟观察站 (VoCEA)
- 批准号:
2214418 - 财政年份:2023
- 资助金额:
$ 18.33万 - 项目类别:
Standard Grant
Comprehensive development strategy of modality-specific "intellectual property" and "cultivation" with an eye on "pharmaceutical affairs" in academia drug discovery
学术界新药研发着眼“药事”的模式“知识产权”与“培育”综合发展策略
- 批准号:
23K02551 - 财政年份:2023
- 资助金额:
$ 18.33万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Accelerating Research Advancement for Investigators Underrepresented in Academia
加速学术界代表性不足的研究人员的研究进展
- 批准号:
10746315 - 财政年份:2023
- 资助金额:
$ 18.33万 - 项目类别:
Planning: HBCU-UP: Strengthening Data Science Research Capacity and Education Programs through Academia-Industry Partnership
规划:HBCU-UP:通过学术界与工业界合作加强数据科学研究能力和教育计划
- 批准号:
2332161 - 财政年份:2023
- 资助金额:
$ 18.33万 - 项目类别:
Standard Grant
From Academia to Business: Development of Novel Therapeutics Against HPV-Associated Cancer
从学术界到商界:针对 HPV 相关癌症的新型疗法的开发
- 批准号:
10813323 - 财政年份:2023
- 资助金额:
$ 18.33万 - 项目类别:
Academics4Rail: Building a community of railway scientific researchers and academia for ERJU and enabling a network of PhDs (academia teaming with industry)
Academys4Rail:为ERJU建立铁路科研人员和学术界社区并建立博士网络(学术界与工业界合作)
- 批准号:
10087488 - 财政年份:2023
- 资助金额:
$ 18.33万 - 项目类别:
EU-Funded
Academics4Rail: Building a Community of Railway Scientific Researchers and Academia for ERJU and Enabling a Network of PhDs (Academia Teaming with Industry)
Academys4Rail:为二院建立铁路科研人员和学术界社区并启用博士网络(学术界与工业界合作)
- 批准号:
10102850 - 财政年份:2023
- 资助金额:
$ 18.33万 - 项目类别:
EU-Funded
Exploring the overall picture of industry-academia-government collaboration: A spectrum of knowledge transfer through formal and informal channels
探索产学官合作的整体图景:通过正式和非正式渠道进行的一系列知识转移
- 批准号:
22K01692 - 财政年份:2022
- 资助金额:
$ 18.33万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Fostering Ethical Neurotechnology Academia-Industry Partnerships: A Stakeholder Engagement and Toolkit Development Project
促进道德神经技术学术界与工业界的伙伴关系:利益相关者参与和工具包开发项目
- 批准号:
10655632 - 财政年份:2022
- 资助金额:
$ 18.33万 - 项目类别: