A chemist's approach to solving biological problems

化学家解决生物学问题的方法

• 批准号: 2417184
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2417184
• 关键词: chemist; approach; solving; biological; problems

An industrial CASE PhD position (over 4 years) is available to work with Dr Vijay Chudasama, Dr James Baker and LifeArc to aid in providing significant steps in this direction via the creation of protein-conjugates generated by site-specific protein modification. The student will carry out his/her doctoral research at UCL and also have the opportunity for work placements at LifeArc. There is a clear need for Organic Chemists to contribute to the field of Biology through the conduit of Chemical Biology. This project will be based on using core synthetic organic chemistry to deliver entities that will meet the needs of forming the next-generation of protein-based therapeutics. In the area of site-selective protein modification, we are at the centre of developing a ground-breaking technology based on the insertion of small molecules bearing reactive handles into native disulfide bonds and cysteines. With our experience, interesting challenges in the modification of certain peptides and proteins have arisen. There is an opportunity to contribute to this area and make a significant impact to the field of Chemical Biology.The student will gain valuable research expertise during the course of this project, making them well qualified for future employment in either an academic or industrial setting. This project will provide a thorough training in synthetic organic chemistry and chemical biology, as well as in a series of transferable skills. The student will also be given plenty of opportunity to be creative, and includes a placement at LifeArc

一个工业案例博士职位(超过4年)可与Vijay Chudasama博士、James Baker博士和LifeArc博士合作，通过创建特定部位的蛋白质修饰产生的蛋白质偶联物，帮助在这一方向上采取重要步骤。该学生将在伦敦大学学院进行博士研究，并有机会在LifeArc找到工作机会。有机化学家显然需要通过化学生物学这一渠道为生物学领域做出贡献。该项目将基于使用核心合成有机化学来提供实体，以满足形成下一代基于蛋白质的疗法的需要。在蛋白质定点修饰方面，我们正处于开发一种突破性技术的中心，该技术基于将带有反应手柄的小分子插入天然二硫键和半胱氨酸中。根据我们的经验，在某些多肽和蛋白质的修饰方面出现了有趣的挑战。有机会为这一领域做出贡献，并对化学生物学领域产生重大影响。在这个项目的过程中，学生将获得宝贵的研究专业知识，使他们能够很好地胜任未来在学术或工业领域的工作。该项目将提供在合成有机化学和化学生物学以及一系列可转让技能方面的全面培训。该学生还将获得大量发挥创造力的机会，包括在LifeArc的实习机会