Molecular Epidemiology of Xenoestrogen Exposure

描述(由申请人提供) 分子流行病学指导研究科学家发展奖是为了支持苏珊·泰特尔鲍姆博士的职业发展，她是一位受过经典训练的癌症流行病学家。K01拨款的主要目的是将泰特尔鲍姆博士定位为一名独立的研究科学家，专门研究多重接触的综合影响的环境和分子流行病学。这项研究的目的是将多种异种雌激素暴露与乳腺癌风险联系起来，将在长岛乳腺癌研究项目中进行检验，这是一项关于乳腺癌和环境的大型人群病例对照研究。传统的慢性病流行病学侧重于单一风险因素--个体水平上的疾病关联，很少考虑多重接触的综合影响，特别是那些相似的生物作用。泰特尔鲍姆博士的职业目标是通过结合流行病学中尚未普遍使用的先进数据分析方法，超越单一暴露与疾病关系的调查。她的培训计划将使她能够深入了解先进的统计方法，以检查多次暴露和基因-环境相互作用的综合影响，更好地了解用于评估异种雌激素暴露的生物标记物的实验室方法，以及处理基因多态的经验。培训计划包括获得生物统计学硕士学位，实验室轮换，以及参加精心挑选的研讨会和国家会议。Teitelbaum博士的提案由Mary Wolff博士(环境/分子流行病学)、Gertrud Berkowitz博士(流行病学)和Sylvan Wallenstein博士(生物统计学)发起。其他顾问将是詹姆斯·韦特穆尔博士(环境遗传学)和阿夫罗姆·卡普兰博士(核受体)。乳腺癌是一种与雌激素相关的疾病，异种雌激素被强烈怀疑是乳腺癌的环境危险因素。除了有机氯化合物(包括滴滴涕、滴滴涕和多氯联苯)外，针对这些环境化学品的研究很少，对这些激素活性物质的综合影响的研究更少。拟议研究项目的结果将具有巨大的公共卫生相关性，因为它们可以增进我们对可改变的乳腺癌风险因素的了解，从而提供对初级预防至关重要的信息。此外，本研究项目中采用的数据分析方法将适用于广泛的与环境有关的疾病。

DESCRIPTION (provided by applicant) The Mentored Research Scientist Development Award In Molecular Epidemiology is requested to support the career development of Dr. Susan Teitelbaum, who is a classically trained cancer epidemiologist. The primary aim of the K01 grant is to position Dr. Teitelbaum as an independent research scientist specializing in the environmental and molecular epidemiology of combined effects of multiple exposures. The research aims, relating multiple xenoestrogen exposure to breast cancer risk, will be examined in the Long Island Breast Cancer Study Project, a large population-based case-control study of breast cancer and the environment. Traditional chronic disease epidemiology focuses on single risk factor-disease associations at the individual level with little consideration of the combined effect of multiple exposures, particularly those of similar biological action. Dr. Teitelbaum's career goal is to advance beyond the investigation of single exposure-disease relationships by incorporating advanced data analytic approaches not yet commonly used in epidemiology. Her training program will enable her to acquire in-depth knowledge of advanced statistical methods for examining the combined effect of multiple exposures and gene-environment interactions, a better understanding of the laboratory methods used to assess biomarkers of xenoestrogen exposure, and experience in working with genetic polymorphisms. The training program includes obtaining a Master's degree in biostatistics, laboratory rotations, and attendance at carefully chosen symposia and national meetings. Dr. Teitelbaum's proposal is sponsored by Dr. Mary Wolff (environmental/molecular epidemiology), Dr. Gertrud Berkowitz (epidemiology), and Dr. Sylvan Wallenstein (biostatistics). Additional advisors will be Drs. James Wetmur (environmental genetics) and Avrom Caplan (nuclear receptors). Breast cancer is an estrogen-related disease and xenoestrogens are strongly suspected to be environmental risk factors for breast cancer. With the exception of organochlorine compounds (including DDT, DDE and PCBs), little research has been directed at these environmental chemicals and even less has been focused on the combined effect of these hormonally active agents. Results of the proposed research project will be of enormous public health relevance since they may advance our knowledge of modifiable breast cancer risk factors, thereby providing information that is essential for primary prevention. Furthermore, data analysis approaches applied in this research project will be applicable to a wide range of environmentally associated diseases.