Human Health Exposure Analysis Resource (HHEAR) Data Center

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Project Summary NIH funded the Human Health Exposure Analysis Resource (HHEAR) a coordinated network of laboratories and statistical and data science resources, designed to provide access to comprehensive exposure analyses using biological samples collected in studies of children’s health. The HHEAR Data Center (DC) is located at the Icahn School of Medicine at Mount Sinai. The NIH created a seven-year initiative, the Environmental Influences on Child Health Outcomes (ECHO) program with the aim of bringing separate children’s cohorts together into one large ECHO-wide Cohort so that ECHO investigators and the wider scientific community can study the effects of early environmental exposures on child health and development. To support ECHO’s goals, the HHEAR lab network has been analyzing biological samples collected by the cohorts for a wide variety of environmental exposure biomarkers. The laboratory results from these analyses are uploaded to the HHEAR DC for quality assurance (QA) and quality control (QC) before the results are transferred to the ECHO Data Analysis Center (DAC). The purpose of this supplement application is to enable the HHEAR DC to support the activities of ECHO that are beyond the current work scope of HHEAR but within the abilities of the DC. Through this supplement application, we will: generate core sample ID’s, provide review of the HHEAR lab results including consultation with the labs on this review; perform quality control and assurance on the lab results; produce a lab results QC report; and coordinate data flow support to integrate laboratory analyses into the ECHO Data Analysis Center. The proposed supplement activities are needed to increase the ability of the HHEAR DC to extend our originally proposed work to accommodate the additional work that is required to provide collaboration, support and services to the ECHO network. This supplement will ensure that the HHEAR Data Center can provide the means for the efficient working of the ECHO program and provide continued support that will contribute to the overall success of the ECHO program.