Human Health Exposure Analysis Resource (HHEAR) Data Center

人类健康暴露分析资源 (HHEAR) 数据中心

• 批准号: 10873509
• 负责人: SUSAN L TEITELBAUM
• 金额: $ 9.87万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10873509
• 关键词: Acceleration; Biological; Biological Markers; Child; Child Development; Child Health; Collaborations; Communities; Consultations; Data; Data Analyses; Data Coordinating Center; Development; Ensure; Environment; Environmental Exposure; Environmental Health; Funding; Goals; Health; Human; Investments; Laboratories; Methodology; Outcome; Process; Production; Quality Control; Reporting; Research; Research Personnel; Resolution; Resources; Sampling; Services; Time; United States National Institutes of Health; Work; cohort; data centers; data exchange; data resource; data science resource; design; medical schools; programs; quality assurance; success; working group

Project Summary NIH funded the Human Health Exposure Analysis Resource (HHEAR) a coordinated network of laboratories and statistical and data science resources, designed to provide access to comprehensive exposure analyses using biological samples collected in studies of children’s health. The HHEAR Data Center (DC) is located at the Icahn School of Medicine at Mount Sinai. The NIH created a seven-year initiative, the Environmental Influences on Child Health Outcomes (ECHO) program with the aim of bringing separate children’s cohorts together into one large ECHO-wide Cohort so that ECHO investigators and the wider scientific community can study the effects of early environmental exposures on child health and development. To support ECHO’s goals, the HHEAR lab network has been analyzing biological samples collected by the cohorts for a wide variety of environmental exposure biomarkers. The laboratory results from these analyses are uploaded to the HHEAR DC for quality assurance (QA) and quality control (QC) before the results are transferred to the ECHO Data Analysis Center (DAC). The purpose of this supplement application is to enable the HHEAR DC to support the activities of ECHO that are beyond the current work scope of HHEAR but within the abilities of the DC. Through this supplement application, we will: generate core sample ID’s, provide review of the HHEAR lab results including consultation with the labs on this review; perform quality control and assurance on the lab results; produce a lab results QC report; and coordinate data flow support to integrate laboratory analyses into the ECHO Data Analysis Center. The proposed supplement activities are needed to increase the ability of the HHEAR DC to extend our originally proposed work to accommodate the additional work that is required to provide collaboration, support and services to the ECHO network. This supplement will ensure that the HHEAR Data Center can provide the means for the efficient working of the ECHO program and provide continued support that will contribute to the overall success of the ECHO program.

项目摘要 NIH资助了人类健康暴露分析资源(HHEAR)，这是一个协调的实验室网络 以及统计和数据科学资源，旨在提供全面的暴露分析 使用在儿童健康研究中收集的生物样本。HHEAR数据中心(DC)位于 位于西奈山的伊坎医学院。美国国立卫生研究院创建了一项为期七年的倡议，即环境 对儿童健康结果的影响(ECHO)计划，目的是将不同的儿童队列 共同组成一个庞大的回声范围队列，以便回声调查人员和更广泛的科学界能够 研究早期环境暴露对儿童健康和发育的影响。以支持Echo的 目标，HHEAR实验室网络已经对队列收集的生物样本进行了广泛的分析 各种环境暴露生物标志物。这些分析的化验结果已上载至 在将结果传输到ECHO之前，HHEAR DC进行质量保证(QA)和质量控制(QC) 数据分析中心(DAC)。此补充应用程序的目的是使HHEAR DC能够 支持超出HHEAR当前工作范围但在HHEAR能力范围内的ECHO活动 华盛顿特区。通过此补充申请，我们将：生成核心样本ID，提供HHEAR审查 实验室结果，包括与实验室就此审查进行协商；执行质量控制和保证 实验室结果；生成实验室结果QC报告；协调数据流支持，以整合实验室 回波数据分析中心。 建议的补充活动是为了提高HHEAR DC的能力，以扩大我们的 最初提议的工作，以适应提供协作、支持所需的额外工作 并向ECHO网络提供服务。本附录将确保HHEAR数据中心能够提供 为ECHO计划的有效工作提供手段，并提供持续的支持，这将有助于 ECHO计划总体上取得了成功。

项目成果

A Parental Smoking Cessation Intervention in the Pediatric Emergency Setting: A Randomized Trial.

• DOI: 10.3390/ijerph17218151
• 发表时间: 2020-11-04
• 期刊: International journal of environmental research and public health
• 作者: Mahabee-Gittens EM;Ammerman RT;Khoury JC;Tabangin ME;Ding L;Merianos AL;Stone L;Gordon JS
• 通讯作者: Gordon JS

Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls.

• DOI: 10.1016/j.envint.2022.107586
• 发表时间: 2022-12
• 期刊: ENVIRONMENT INTERNATIONAL
• 影响因子: 11.8
• 作者: Yoon, Lara S.;Binder, Alexandra M.;Pereira, Ana;Calafat, Antonia M.;Shepherd, John;Corval, Camila;Michels, Karin B.
• 通讯作者: Michels, Karin B.

IDSL.UFA Assigns High-Confidence Molecular Formula Annotations for Untargeted LC/HRMS Data Sets in Metabolomics and Exposomics.

• DOI: 10.1021/acs.analchem.2c00563
• 发表时间: 2022-10-04
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Baygi, Sadjad Fakouri;Banerjee, Sanjay K.;Chakraborty, Praloy;Kumar, Yashwant;Barupal, Dinesh Kumar
• 通讯作者: Barupal, Dinesh Kumar

Uncovering neurodevelopmental windows of susceptibility to manganese exposure using dentine microspatial analyses.

• DOI: 10.1016/j.envres.2017.12.003
• 发表时间: 2018-03
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Claus Henn B;Austin C;Coull BA;Schnaas L;Gennings C;Horton MK;Hernández-Ávila M;Hu H;Téllez-Rojo MM;Wright RO;Arora M
• 通讯作者: Arora M

Corrigendum to "Extending the Distributed Lag Model framework to handle chemical mixtures" [Environ. Res. 156 (2017) 253-264].

“扩展分布式滞后模型框架以处理化学混合物”的勘误 [Environ。

• DOI: 10.1016/j.envres.2017.09.001
• 发表时间: 2017
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Bello,GhalibA;Arora,Manish;Austin,Christine;Horton,MeganK;Wright,RobertO;Gennings,Chris
• 通讯作者: Gennings,Chris