Development and implementation of a comparison occupational cohort for the WTC GRC

为 WTC GRC 开发和实施比较职业群体

• 批准号: 9769592
• 负责人: SUSAN L TEITELBAUM
• 金额: $ 50万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9769592
• 关键词: Development; implementation; comparison; occupational; cohort

Project Summary World Trade Center (WTC) first responders have suffered numerous diseases and conditions as a result of their efforts on 9/11 and afterwards. For example, it has been noted that there are numerous cases of aerodigestive disorders amongst the responders, including sinusitis, asthma, interstitial lung disease, and gastroesophageal reflux. Similarly, there are reports of higher than expected rates of certain cancers, such as multiple myeloma, prostate, and thyroid. Also reported are relatively high rates of post-traumatic stress disorder, anxiety, depression, and sleep apnea. The commonality in these reports is the comparator groups against which the data from the WTC General Responders Cohort (WTC-GRC) were measured. The comparator groups were either national or local (e.g., the NY State Cancer Registry) and were composed of members of the general population, not occupational groups. The purpose of this proposal is the development of a unique occupational cohort, based in part on patients attending the Mount Sinai Selikoff Centers for Occupational Health (SCOH), as well as workers presenting to other departments within Mount Sinai, and workers recruited through outreach efforts. The reasoning is that for valid estimates of the health of the first responders, comparisons must be against a working population and not the general population, which can lead to intractable bias and faulty assessments. The specific aims of the proposed project include: 1) converting existing SCOH data into a usable database for comparative analyses of WTC-related health conditions; 2) building a new occupational cohort to serve as a comparison in the longitudinal assessment of health in the WTC-GRC; and 3) utilizing the newly created comparison cohort to determine if gastroesophageal reflux disease (GERD) incidence in the WTC-GRC differs from an unexposed worker population. The results of the proposed project will improve the quality of the health related studies being done by providing a more appropriate comparison group that can be matched to responders on several important characteristics, including occupation, age, sex and race/ethnicity. Such studies will result in improved estimates of disease risk and add important knowledge to what we currently understand about exposure to 9/11 toxins and stressors.

项目摘要 世界贸易中心（WTC）的第一反应者遭受了许多疾病和条件的结果， 他们在9/11和之后的努力。例如，有人指出，有许多情况下， 应答者中的呼吸消化系统疾病，包括鼻窦炎、哮喘、间质性肺病，以及 胃食管反流同样，也有报告称某些癌症的发病率高于预期，如 多发性骨髓瘤前列腺和甲状腺据报道，创伤后应激反应的发生率也相对较高 焦虑抑郁和睡眠呼吸暂停这些报告的共同点是比较组 对照WTC一般应答者队列（WTC-GRC）的数据进行测量。的 比较组是国家或地方的（例如，纽约州癌症登记处），由 一般人群，而不是职业群体。这项提案的目的是发展 一个独特的职业队列，部分基于参加西奈山Selikoff中心的患者， 职业卫生（SCOH），以及西奈山内其他部门的工人，以及 通过外联工作征聘的工作人员。理由是，为了有效估计第一个人的健康状况， 响应者，比较必须针对工作人群，而不是一般人群，这可能导致 顽固的偏见和错误的评估。 拟议项目的具体目标包括：1）将现有SCOH数据转换为可用数据库， 比较分析与世界贸易中心有关的健康状况; 2）建立一个新的职业群体， 比较WTC-GRC中的纵向健康评估;以及3）利用新创建的 比较队列，以确定WTC-GRC中胃食管反流病（GERD）的发生率是否不同 从未暴露的工人群体中。 拟议项目的结果将提高正在进行的健康相关研究的质量， 提供了一个更合适的比较组，可以在几个重要的方面与反应者相匹配， 特征，包括职业、年龄、性别和种族/民族。这些研究将改善 估计疾病风险，并增加重要的知识，我们目前了解的接触， 9/11毒素和压力源。