P-30 Core Grant for Vision Research

这是来自马萨诸塞州眼耳医院的视觉科学家的一项新应用，旨在寻求对共享设施和服务的支持。我们的目标是提高我们的个人研究计划的生产力，创造新的研究工作的机会，并促进合作努力，以确定正常眼睛功能的分子，细胞和遗传基础和眼病的起源。请求为四个单元提供支助。1. 形态学和显微镜模块将提供资源，服务和技术援助，进行激光扫描共聚焦显微镜，透射电子显微镜和光学显微镜。2.分子生物学模块将提供DNA测序和一般分子生物学服务和用品。此外，它还将支持共用设备的维护以及成像中心和组织培养设施的管理和运作。3.计算机服务模块将为研究人员提供技术援助，以优化用于研究目的的计算机配置，将计算机与实验室设备连接起来，创建和维护数据库，传输和存储大型数据和图像文件，并维护一个专门供研究界使用的服务器。它还将为核心补助金的其他模块提供广泛的支持。4.临床接口模块将为需要采集人体血液的研究项目提供帮助。这将有助于淋巴细胞沉淀的制备和储存，DNA样本的制备，以及包含与储存血液样本的患者相关的临床信息的数据库的维护。我们的部门致力于最有效的研究计划应该建立在多学科的方法，涉及基础和临床科学家的努力的理念。继强大的机构支持的传统，该部门保持在此应用程序中讨论的研究工作的一个极好的环境。这项核心补助金将提供重要的资源，以保证我们的计划的持续卓越，并将为进一步的教学和研究机会贡献关键资源。

This is a new application from vision scientists at the Massachusetts Eye and Ear Infirmary seeking support for shared facilities and services. We aim to enhance the productivity of our individual research programs, create opportunities for new research endeavors, and promote collaborative efforts in identifying the molecular, cellular and genetic bases of normal eye function and the origins of eye diseases. Support is requested for four modules. 1. The Morphology and Microscopy Module will provide resources, services and technical assistance in conducting laser scanning confocal microscopy, transmission electron microscopy, and light microscopy. 2. The Molecular Biology Module will provide DNA sequencing and general molecular biology services and supplies. In addition, it will support the maintenance of shared equipment and the management and operation of the imaging center and the tissue culture facility. 3. The Computer Service Module will provide researchers with technical assistance to optimize computer configurations for research purposes, interface computers with laboratory equipment, create and maintain databases, transfer and store large data and image files, and maintain a server dedicated for use by the research community. It will also provide extensive support for the other modules of this Core Grant. 4. The Clinical Interface Module will provide assistance to research programs requiring human blood collection. It will facilitate the preparation and storage of lymphocyte pellets, preparation of DNA samples, and maintenance of databases containing clinical information related to patients with stored blood samples. Our Department is committed to the philosophy that the most efficient research program should be built on a multi-disciplinary approach involving the efforts of both basic and clinical scientists. Following a tradition of strong institutional support, the Department maintains a superb environment for the research endeavors discussed in this application. This core grant will provide important resources to guarantee the continued excellence of our program and will contribute critical resources for further teaching and research opportunities.