P-30 Core Grant for Vision Research

这是麻省眼耳医院的视觉科学家为共享设施和服务寻求支持的一项新应用。我们的目标是提高我们个人研究项目的生产力，为新的研究努力创造机会，并促进在确定正常眼功能和眼病起源的分子、细胞和遗传基础方面的合作努力。要求支持四个模块。1. 形态学和显微镜模块将提供进行激光扫描共聚焦显微镜、透射电子显微镜和光学显微镜的资源、服务和技术援助。2. 分子生物学模块将提供DNA测序和一般分子生物学服务和用品。此外，它将支持共享设备的维护以及成像中心和组织培养设施的管理和运营。3. 计算机服务模块将为研究人员提供技术支持，以优化计算机配置以用于研究目的，将计算机与实验室设备连接起来，创建和维护数据库，传输和存储大数据和图像文件，并维护专用于研究社区使用的服务器。它还将为本核心基金的其他模块提供广泛的支持。临床接口模块将为需要采集人体血液的研究项目提供帮助。它将促进淋巴细胞微球的制备和储存，DNA样本的制备，以及保存血液样本患者临床信息数据库的维护。我们部门致力于最有效的研究项目应该建立在多学科的方法上，包括基础和临床科学家的努力。遵循强大的机构支持的传统，该部门为本应用程序中讨论的研究工作保持了极好的环境。这项核心拨款将为保证我们项目的持续卓越提供重要资源，并将为进一步的教学和研究机会提供关键资源。

This is a new application from vision scientists at the Massachusetts Eye and Ear Infirmary seeking support for shared facilities and services. We aim to enhance the productivity of our individual research programs, create opportunities for new research endeavors, and promote collaborative efforts in identifying the molecular, cellular and genetic bases of normal eye function and the origins of eye diseases. Support is requested for four modules. 1. The Morphology and Microscopy Module will provide resources, services and technical assistance in conducting laser scanning confocal microscopy, transmission electron microscopy, and light microscopy. 2. The Molecular Biology Module will provide DNA sequencing and general molecular biology services and supplies. In addition, it will support the maintenance of shared equipment and the management and operation of the imaging center and the tissue culture facility. 3. The Computer Service Module will provide researchers with technical assistance to optimize computer configurations for research purposes, interface computers with laboratory equipment, create and maintain databases, transfer and store large data and image files, and maintain a server dedicated for use by the research community. It will also provide extensive support for the other modules of this Core Grant. 4. The Clinical Interface Module will provide assistance to research programs requiring human blood collection. It will facilitate the preparation and storage of lymphocyte pellets, preparation of DNA samples, and maintenance of databases containing clinical information related to patients with stored blood samples. Our Department is committed to the philosophy that the most efficient research program should be built on a multi-disciplinary approach involving the efforts of both basic and clinical scientists. Following a tradition of strong institutional support, the Department maintains a superb environment for the research endeavors discussed in this application. This core grant will provide important resources to guarantee the continued excellence of our program and will contribute critical resources for further teaching and research opportunities.