Core--Tissue Procurement

核心——组织采购

• 批准号: 6998213
• 负责人: Mark A. Watson
• 金额: $ 8.24万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-21 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6998213
• 关键词: biomedical facility; cancer registry /resource; laser capture microdissection; microarray technology; neoplasm /cancer

The Tissue Procurement Core is designed to facilitate human specimen-based cancer research. The Core assists Siteman Cancer Center (SCC) investigators in all aspects of prospective study design, from the development of appropriate informed consent documents to protocols for specimen collection, storage and processing. The Core also maintains an archive of several thousand snap frozen tissue specimens representing both common and rare tumor types. Approved investigators may immediately access these specimens for retrospective translational studies. Emphasis is placed on delivering quality-controlled histological sections or purified macromolecules (RNA, genomic DNA, protein extracts) to the investigator for immediate use in histological, genetic or biochemical studies. In addition, the Core provides SCC members access to new technologies for tissue-based research, such as Laser Capture Tissue Microdissection (LCM) and Tissue Microarray (TMA) construction. To date, the Core has assisted several funded SCC members from multiple research programs (both basic science and clinical investigation) in the collection and utilization of human tumor tissue specimens.

Tissue Procurement Core旨在促进基于人类肿瘤的癌症研究。核心协助Siteman癌症中心（SCC）研究人员进行前瞻性研究设计的各个方面，从制定适当的知情同意文件到样本采集、储存和处理方案。该中心还保存了数千份代表常见和罕见肿瘤类型的快速冷冻组织标本。经批准的研究者可立即获取这些标本进行回顾性转化研究。重点是将质量受控的组织切片或纯化的大分子（RNA，基因组DNA，蛋白质提取物）提供给研究者，以立即用于组织学，遗传学或生物化学研究。此外，核心还为SCC成员提供 获得用于组织研究的新技术，如激光捕获组织显微切割（LCM）和组织微阵列（TMA）构建。到目前为止，该中心已协助多个研究项目（包括基础科学和临床研究）的几个资助SCC成员收集和利用人类肿瘤组织标本。