Washington University Center for Translational Neuroscience

华盛顿大学转化神经科学中心

• 批准号: 7321049
• 负责人: Mark A. Watson
• 金额: $ 23.01万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-25 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7321049
• 关键词: Alzheimer' s disease; human; nervous system disorder; university

Facilitated access to high quality, clinically annotated biospecimens is critical for leveraging new genomic and proteomic technologies to better understand diseases of the human nervous system. On-going efforts at our institution have created several biospecimen repositories for select nervous system disorders such as Alzheimer's disease, but human specimen resources are less adequate for many other disease types. Accordingly, the goal of the Biospecimen and Clinical Data Acquisition Core is to facilitate the coordinated collection, processing, storage, and distribution of biospecimens and clinical data from patients within a broad representation of disorders of the nervous system. The first aim of this core is to initiate the collection of biospecimens and associated clinical data from patient populations where little support currently exists. The Core will assist investigators who wish to collect biospecimens for specific research protocols, but will also act as a more general resource to bank biospecimens from patients with disorders of the nervous system for future retrospective studies. Collected specimens will include serum, plasma, CSF, genomic DNA, and in some cases, tissue (e.g. surgically resected epileptic foci). Where appropriate, such as in diseases as multiple sclerosis, emphasis will be placed on collecting samples at multiple time points to create a set of biospecimens that can be analyzed over the patient's clinical course. The second aim of this core is to catalyze the integration of several large, pre-existing biorepositories and clinical databases using a set of common data elements and a web-based biospecimen informatics system ("nsTissue Core") to create a virtual repository of biospecimens from patients with a wide variety of neurological and psychaitric diseases. As part of this aim, we will also seek to harmonize collection and processing protocols and to share technical resources, making the collection of biospecimens from patients with disorders of the nervous system at our institution more efficient and uniform. As a model for this approach, we will seek to integrate resources from our Alzheimer's Disease Research Center (ADRC) and the Movement Disorders Clinic. The third aim of this core is to make accessible an inventory of available biospecimen resources and deidentified data generated from the first two aims. Authorized intramural and extramural neuroscience investigators will be able to query this resource, for the purposes of sharing collected biospecimens to promote novel translational studies and collaborations in translational neuroscience.

方便地获得高质量的、经过临床注释的生物标本是利用新基因组的关键 以及蛋白质组学技术，以更好地了解人类神经系统疾病。持续的努力 在我们机构创建了几个针对特定神经系统疾病的生物谱系存储库，例如 阿尔茨海默氏症，但人类标本资源对许多其他类型的疾病来说不够充分。 因此，生物医学和临床数据采集核心的目标是促进协调 收集、处理、存储和分发来自患者的生物样本和临床数据 神经系统疾病的广泛表现。这个核心的第一个目标是启动收集 从目前几乎不存在支持的患者群体中收集生物样本和相关的临床数据。 核心将协助那些希望为特定研究方案收集生物标本的调查人员，但将 也可以作为一个更通用的资源来储存神经性疾病患者的生物标本 为今后的回溯性研究提供了一个系统。采集的样本包括血清、血浆、脑脊液、基因组 DNA，在某些情况下，组织(例如，手术切除的癫痫灶)。在适当的地方，例如在 多发性硬化症等疾病，重点将放在多个时间点收集样本，以 创建一套可以在患者的临床过程中进行分析的生物显微镜。这样做的第二个目的是 核心是使用一种 一组通用数据元素和一个基于Web的生物质学信息学系统(“nsTIssue Core”)，以创建 一个来自各种神经学和精神病学患者的生物标本的虚拟储存库 疾病。作为这一目标的一部分，我们还将努力协调收集和处理协议，并 共享技术资源，收集神经性疾病患者的生物标本 我们机构的系统更加高效和统一。作为这种方法的典范，我们将寻求将 资源来自我们的阿尔茨海默病研究中心(ADRC)和运动障碍诊所。这个 这一核心的第三个目标是提供一份可利用的生物菌种资源清单，并确定 前两个目标产生的数据。授权的壁内和壁外神经科学 调查人员将能够查询这一资源，以便将收集到的生物标本共享给 促进在翻译神经科学方面的新的翻译研究和合作。