Transmembrane Signaling through Voltage-gated Ca Channel

通过电压门控 Ca 通道的跨膜信号传导

• 批准号: 6828648
• 负责人: Lutz Birnbaumer
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6828648
• 关键词: G protein; biological signal transduction; calcium channel; cues; dihydropyridines; electrophysiology; environment; mass spectrometry; phosphorylation; recombinant proteins; serine; voltage /patch clamp; voltage gated channel

The importance of a serine in the selectivity pore of the cardiac Ca channel was studied and shown to be essential for survival after excision as well as for activation by a dihydropyridine (Bay K8644). The data imply existence of an essential phosphorylation site of unknown location.

研究了丝氨酸在心脏Ca通道的选择性孔中的重要性，结果表明，丝氨酸对切除后的存活以及二氢吡啶（Bay K8644）的激活至关重要。这些数据表明存在一个未知位置的重要磷酸化位点。