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Spatial Representations and Attention

空间表征和注意力

基本信息

批准号：
6759406
负责人：
LYNN Clarine ROBERTSON
金额：
$ 22.35万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-07-01 至 2006-06-30
项目状态：
已结题

项目摘要

Several studies that combine behavioral methods with anatomical data in neurological patients have complimented evidence for two very general processing streams through the cortex, one involved in spatial processing (occipital-parietal) and the other in the perception and recognition of objects and their features (occipital-temporal). However, our preliminary work using chronometric measures reveals that despite the nearly complete loss of spatial abilities with relatively large bilateral dorsal lesions, spatial maps existed intact below the level of spatial awareness. These findings evolved from other preliminary work showing that bilateral occipital-parietal damage in humans affects how features are bound (presumably through ventral /dorsal interactions), suggesting a larger role for dorsal spatial functioning in object perception than previously recognized. When extensive loss of spatial awareness occurs, as with bilateral damage to the dorsal stream, shape perception remains but binding shape to surface features such as color, size or motion is severely disrupted. The proper binding of features appears to require explicit spatial knowledge that relies on dorsal systems. Although implicit spatial information remains intact, proper binding appears to require explicit awareness. The evidence is consistent with multiple spatial maps. Two sets of proposed studies are designed to explore targeted regions that may disrupt implicit spatial information and to determine the relationship of bilateral dorsal damage to unilateral damage that often produce other spatial deficits such as seen with unilateral inattention or hemineglect. Other sets of studies are designed to begin to explore the cognitive operations that contribute to implicit spatial effects observed in neuropsychological syndromes. The studies should help to determine the impact of cortical damage and underlying mechanisms that remain intact, potentially aiding in rehabilitation efforts and patient management. The translational potential of the work adds to the proposal's strength.

有几项研究将联合收割机的行为方法与神经系统患者的解剖学数据结合起来，补充了两个非常普遍的大脑皮层处理流的证据，一个涉及空间处理（枕-顶），另一个涉及对物体及其特征的感知和识别（枕-颞）。然而，我们的初步工作，使用计时措施表明，尽管几乎完全丧失的空间能力与相对较大的双边背病变，空间地图存在完整的空间意识水平以下。这些发现来自其他初步工作，表明人类双侧枕顶叶损伤会影响特征的结合方式（可能是通过腹侧/背侧相互作用），这表明背侧空间功能在物体感知中的作用比以前认识到的更大。当发生广泛的空间意识丧失时，如双侧背流损伤，形状感知仍然存在，但将形状与表面特征（如颜色，大小或运动）结合在一起会受到严重破坏。正确的绑定功能似乎需要明确的空间知识，依赖于背系统。虽然隐含的空间信息保持完整，适当的绑定似乎需要明确的意识。证据与多个空间地图一致。两组拟议的研究旨在探索可能破坏内隐空间信息的目标区域，并确定双边背侧损伤与单侧损伤的关系，后者通常会产生其他空间缺陷，如单侧注意力不集中或偏侧运动障碍。其他研究的目的是开始探索认知操作，有助于观察到的内隐空间效应的神经心理综合征。这些研究应该有助于确定皮质损伤的影响和保持完整的潜在机制，可能有助于康复工作和患者管理。这项工作的翻译潜力增加了提案的力量。