Tomographic Microscope for Assessing Microcirculation

用于评估微循环的断层扫描显微镜

• 批准号: 6831425
• 负责人: PAUL SHNITSER
• 金额: $ 7.68万
• 依托单位: PHYSICAL OPTICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2005-03-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6831425
• 关键词: arterioles; bioimaging /biomedical imaging; biomedical equipment development; chick embryo; computer program /software; erythrocytes; imaging /visualization /scanning; microcirculation; microscopy; noninvasive diagnosis; optical tomography; optics; portable biomedical equipment

DESCRIPTION (provided by applicant): Many widespread diseases are caused by or manifested in abnormalities in blood microcirculation. There is a pressing need for a noninvasive device to collect maximum information about the structure of the microcirculation network, the functional parameters of blood microcirculation such as a blood flow velocity and blood oxygen saturation, and tissue morphology. To satisfy this need, Physical Optics Corporation (POC) proposes to develop a new multiwavelength optical coherent Doppler tomography (MOCDOT) microscope capable of 3D visualization of tissue morphology to a depth up to several millimeters, and of separate visualization of the microvascular network with measurement of the blood flow velocities in each component of this network and of arteriolar blood oxygenation. These multiple functions will be achieved by the unique combination of en-face optical coherence tomography with heterodyne measurements of the Doppler shift induced by light scattering by moving red blood cells. In Phase I, POC will fabricate a prototype of the MOCDOT microscope, and will demonstrate the performance on a chick embryo. After evaluating the test results, POC will optimize the MOCDOT design in preparation for developing a Phase II working prototype for clinical testing on patients who might have diabetic microangiopathy.

描述(申请人提供)：许多广泛传播的疾病都是由血液微循环异常引起或表现出来的。迫切需要一种非侵入性设备来收集有关微循环网络结构、血液微循环功能参数(如血流速度和血氧饱和度)以及组织形态的最大信息。为了满足这一需求，物理光学公司(POC)建议开发一种新的多波长光学相干多普勒断层扫描(MOCDOT)显微镜，能够对组织形态进行3D可视化，深度可达几毫米，并能够通过测量微血管网络每个组件中的血流速度和微动脉血氧来单独显示微血管网络。这些多重功能将通过独特的内面光学相干断层扫描和外差测量相结合来实现，该测量是由移动的红细胞的光散射引起的多普勒频移。在第一阶段，POC将制造MOCDOT显微镜的原型，并将在鸡胚上展示其性能。在评估测试结果后，POC将优化MOCDOT设计，为开发第二阶段工作原型做准备，用于对可能患有糖尿病微血管病变的患者进行临床测试。