Fast Acousto-Optic Tomography System

快速声光断层扫描系统

• 批准号: 7909641
• 负责人: PAUL SHNITSER
• 金额: $ 99.85万
• 依托单位: PHYSICAL OPTICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7909641
• 关键词: Acoustics; Affect; Breast; Breast Cancer Early Detection; California; Cancer Diagnostics; Detection; Development; Diagnostic; Early Diagnosis; Engineering; Female breast; Focused Ultrasound Therapy; Frequencies; Goals; Image; Imaging Device; Investigation; Laboratories; Life; Light; Location; Malignant - descriptor; Mammary Gland Parenchyma; Mammography; Maps; Medical center; Memory; Needle biopsy procedure; Neoplasms; Normal tissue morphology; Optics; Organ; Patients; Phase; Photons; Predictive Value; Probability; Property; Prostate; Protocols documentation; Research; Resolution; Screening procedure; Signal Transduction; Specificity; Speed; System; Techniques; Technology; Testing; Time; Tissues; Ultrasonography; Variant; cancer therapy; design; diffuse optical tomography; heterodyning; human subject; improved; innovation; instrumentation; malignant breast neoplasm; operation; prototype; public health relevance; time interval; tomography; tool; tumor

DESCRIPTION (provided by applicant): To improve the probability of earlier breast cancer detection while reducing the number of unnecessary needle biopsies, Physical Optics Corporation proposes to develop a new Fast Acousto-Optic Tomography System (FAOTS) as an auxiliary tool for the conventional ultrasound breast examination that often follows a screening mammography. The innovative FAOTS will provide images with better contrast than sonography, because the optical properties of normal tissue and tissue with neoplasia differ much more than their acoustic properties. FAOTS will use a tightly focused ultrasound beam to shift the frequency of photons at a certain location in a tissue and detect them using a heterodyne technique utilizing a parallel signal acquisition by multiple photodetectors on a fast CMOS chip. The utilization of a high-speed (>4000 fps) CMOS camera with a large memory capacity enables signal detection in a short time interval, so speckle decorrelation in the live tissue will not affect system operation. In Phase I, POC experimentally demonstrated the capability of the laboratory prototype of obtaining high contrast signals with a speed exceeding the speckle decorrelation time. In Phase II, POC will design and fabricate an engineering FAOTS prototype and conduct a demonstration of its capability of mapping the optical properties of patient breast tissue at Harbor-UCLA Medical Center in Torrance, California. The fully developed FAOTS will provide a spatial resolution of ~0.4 mm, which is significantly better than Optical Diffuse Tomography (ODT). The FAOTS technology will enable positive predictive value (PPV) improvement in breast cancer diagnostics, with earlier detection of smaller tumors, thus enhancing patients' chances for long-time survival after cancer treatment. The successful demonstration of the FAOTS technology for mapping the optical properties of breast tissue will broaden the perspective for the extension of the FAOTS technology using multiple light wavelengths for improving image contrast. It will also facilitate development of special instrumentation for mapping the optical properties of other internal organs, and better diagnostics of tumors in these organs (e.g., prostate).

描述(申请人提供)：为了提高早期发现乳腺癌的可能性，同时减少不必要的针吸活组织检查的数量，物理光学公司建议开发一种新的快速声光断层扫描系统(FAOTS)，作为通常在筛查乳房X光检查后进行的常规超声乳房检查的辅助工具。创新的FAOTS将提供比超声波更好的对比度，因为正常组织和肿瘤组织的光学属性的差异远远超过它们的声学属性。FAOTS将使用紧密聚焦的超声束在组织中的某个位置移动光子的频率，并使用外差技术检测它们，该技术利用快速cmos芯片上的多个光电探测器并行采集信号。利用具有大存储容量的高速(&gt；4000 fps)cmos摄像机，能够在短时间间隔内检测信号，因此活体组织中的散斑去相关不会影响系统操作。在第一阶段，POC实验演示了实验室原型以超过散斑去相关时间的速度获得高对比度信号的能力。在第二阶段，POC将设计和制造一个工程FAOTS原型，并在加利福尼亚州托兰斯的Harbor-UCLA医疗中心展示其绘制患者乳房组织光学特性图的能力。完全开发的FAOTS将提供~0.4 mm的空间分辨率，这明显优于光学漫反射层析成像(ODT)。FAOTS技术将提高乳腺癌诊断的阳性预测值(PPV)，及早发现较小的肿瘤，从而提高患者在癌症治疗后长期存活的机会。FAOTS技术用于绘制乳房组织光学特性图的成功演示，将为FAOTS技术的推广拓宽前景，使用多个光波长来提高图像对比度。它还将促进特殊仪器的开发，以绘制其他内部器官的光学特性图，并更好地诊断这些器官中的肿瘤(例如前列腺)。