Fast-Acoustico Optic Tomography System

快速声光学断层扫描系统

• 批准号: 7608992
• 负责人: PAUL SHNITSER
• 金额: $ 14.99万
• 依托单位: PHYSICAL OPTICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608992
• 关键词: Accounting; Acoustics; Address; Affect; Algorithms; Attenuated; Automobile Driving; Back; Biological; Biomedical Engineering; Bite; Breast; Caliber; Cancer Detection; Cells; Characteristics; Clinical; Code; Computer Systems; Computer Systems Development; Computers; Condition; Data; Data Collection; Dependence; Depth; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic Neoplasm Staging; E 25; Early Diagnosis; Electromagnetics; Electronics; Engineering; Ensure; Female breast; Focused Ultrasound Therapy; Foundations; Fourier Transform; Frequencies; Future; Goals; Health Personnel; Image; Imaging Device; Imaging Techniques; Imaging technology; Individual; Institutes; Invasive; Investigation; Laboratories; Lasers; Lateral; Lead; Left; Length; Lesion; Life; Light; Lighting; Location; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Mammography; Mechanics; Medical Imaging; Memory; Metabolism; Methods; Modeling; Modification; Molecular; Morphologic artifacts; Movement; Neoplasms; Noise; Normal tissue morphology; Numbers; Operative Surgical Procedures; Optics; POMC gene; Patients; Pattern; Performance; Phase; Photons; Physiologic pulse; Physiological; Pleomorphism; Population; Preparation; Probability; Process; Property; Protocols documentation; Public Health; Pulse taking; Puncture biopsy; Radar; Range; Rate; Research; Resolution; Respiratory Diaphragm; Safety; Scanning; Scheme; Screening for cancer; Screening procedure; Semiconductors; Signal Transduction; Solutions; Specificity; Speed; Spottings; Staging; Standards of Weights and Measures; Structure; Support of Research; System; Techniques; Technology; Testing; Thick; Time; Tissues; Transducers; Tumor Burden; Ultrasonic Transducer; Ultrasonic wave; Ultrasonics; Ultrasonography; Variant; Woman; Work; X-Ray Computed Tomography; absorption; angiogenesis; artist; base; bioimaging; cancer cell; charge coupled device camera; chemical property; commercialization; computerized data processing; cost; data acquisition; density; design; detector; evaluation/testing; heterodyning; improved; indexing; innovation; instrumentation; irradiation; laptop; light scattering; millimeter; millisecond; mortality; novel; optical imaging; phantom model; pressure; prototype; research and development; size; soft tissue; time interval; tomography; tool; tumor

DESCRIPTION (provided by applicant): The National Institute of Biomedical Imaging and Bioengineering (NIBIB) supports research development of innovative image acquisition methods based on the combination of acoustic and optical technologies. Physical Optics Corporation proposes development of the new Fast Acousto-Optic Tomography System (FAOTS) as an auxiliary tool to the conventional ultrasound breast examination that often follows a screening mammography. The innovative FAOTS will provide images with better contrast then sonography because the optical properties of normal tissue and tissue with neoplasia differ much more than their acoustic properties. FAOTS will use a tightly focused ultrasound beam to shift the frequency of photons at a certain location in a tissue. The FAOTS performance will be based on a combination of the heterodyne detection scheme and a parallel signal acquisition by multiple photodetectors on the CMOS chip, followed by a Fourier transform in the spatial domain to detect interference fringes between photons with the shifted frequency, and the reference optical beam with the same frequency shift. The utilization of a high speed (>1000 frames per second) CMOS camera with a large memory capacity will allow for data collection in a time interval such that speckle decorrelation in the live tissue will not affect system operation. In Phase I, POC will design, fabricate, assemble, and test the laboratory prototype, and demonstrate its major operational parameters (image resolution, image contrast, and fast data acquisition time, proving its ability to work with living tissues). In Phase II, POC will design and fabricate an engineering prototype for testing its operation in clinical settings. PUBLIC HEALTH RELEVANCE: As an auxiliary tool to conventional breast ultrasound examination following a screening mammography, the proposed Fast Acousto-Optic Tomography System (FAOTS) will improve chances for earlier neoplasia detection by providing images with better contrast than sonography and with comparable (or better) spatial resolution. The contrast enhancement is attributed to higher variations of optical properties for malignant tissues compare to the variation of their acoustic properties. The proposed non-invasive and non-ionizing imaging tool will increase specificity and improve the PPV of breast investigation, while reducing the number of unnecessary needle biopsies.

描述(申请人提供)：美国国家生物医学成像与生物工程研究所(NIBIB)支持基于声学和光学技术相结合的创新图像采集方法的研究开发。物理光学公司建议开发新的快速声光层析成像系统(FAOTS)，作为通常在筛查乳房X光检查后进行的传统超声乳房检查的辅助工具。创新的FAOTS将提供比超声波更好的对比度图像，因为正常组织和肿瘤组织的光学属性比它们的声学属性差异更大。FAOTS将使用紧密聚焦的超声束在组织中的特定位置移动光子的频率。FAOTS的性能将基于外差检测方案和由芯片上的多个光电探测器并行采集信号的组合，然后在空间域进行傅里叶变换，以检测移频的光子和具有相同频移的参考光束之间的干涉条纹。利用具有大存储容量的高速(1000帧/秒)cmos相机将允许在时间间隔内收集数据，使得活组织中的散斑去相关不会影响系统操作。在第一阶段，POC将设计、制造、组装和测试实验室原型，并展示其主要操作参数(图像分辨率、图像对比度和快速数据采集时间，证明其能够处理活组织)。在第二阶段，POC将设计和制造一个工程原型，用于在临床环境中测试其操作。与公众健康相关：作为筛查乳房X光检查后常规乳房超声检查的辅助工具，拟议的快速声光断层扫描系统(FAOTS)将提供比超声更好的对比度和类似(或更好)的空间分辨率的图像，从而提高早期发现肿瘤的机会。对比度增强归因于恶性组织的光学特性的变化比其声学特性的变化更大。建议的非侵入性和非电离成像工具将增加特异性和改善乳腺检查的PPV，同时减少不必要的针吸活组织检查的数量。