Brain Uptake and Utilization of Fatty Acids and Lipids

大脑对脂肪酸和脂质的摄取和利用

• 批准号: 6838021
• 负责人: Paul A. WATKINS
• 金额: $ 2万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838021
• 关键词: blood lipoprotein; brain metabolism; fatty acids; lipid transport; lipids; meeting /conference /symposium; nervous system disorder; travel

DESCRIPTION (provided by applicant) A scientific meeting "Brain Uptake and Utilization of Fatty Acids, Lipids and Lipoproteins: Applications to Neurological Disorders (An International Workshop)" to be held at the Bethesda Holiday Inn Select, October 7-9, 2004, is proposed. The objectives are to examine the current state of knowledge of how lipids, primarily fatty acids (FA), and lipoproteins are taken up and utilized by the brain, to provide a forum for ample interchange of ideas and information between participants of diverse backgrounds, and to identify areas for future research. Workshop topics will include: FA and lipid transport across membranes in the brain; brain metabolism of polyunsaturated FA (PUFA) with emphasis on the physiological functions of eicosenoids; functions of docosahexaenoic acid (DHA) in neurons and neuronal membranes and the roles of DHA and other PUFA in neurological diseases; and roles of lipids and lipoproteins in peroxisomal disorders and in Alzheimer's disease. Continuing disagreement and contreversy over mechanism(s) by which all cells transport FA across the plasma membrane precludes a clear understanding of how FA enter the brain, where this process is further complicated by the presence of the blood-brain barrier. It is vital to clarify brain FA transport and utilization mechanisms, both understanding normal brain development and function and for the diagnosis and therapy of human neurodegenerative diseases, some of which may be amenable to non-invasive, dietary therapy. This conference is timely because a) there is tremendous impetus for brain research with the recent establishment of several new large centers, and b) advances in biochemistry, biophysics, genetics, neuroimaging, and nutrition have led to specialization and an information explosion. We propose that new insights can be consolidated and enhanced by bringing together investigators and clinicians from this wide range of disciplines which will catalyze application of new information to the diagnosis and treatment of human disease. The proposed format of the conference is unique in its emphasis on open discussions of the issues, their implications and contreversies rather than on didactic presentation. Expected outcomes include emergence of new hypotheses and establishment of new collaborations that integrate different disciplines. Our previous conference in March 2000, with similar objectives, was highly successful in the eyes of participants, attendees, and sponsors. The entire proceedings, including talks, posters, discussions, and recommendations for future research were published in a double issue of J. Mol. Neurosci., which has committed to publish the proceedings of the proposed meeting.

描述（由申请人提供）一场科学会议“脂肪酸，脂质和脂蛋白的大脑吸收和利用：对神经系统疾病的申请（国际研讨会）将于2004年10月7日至9日在贝塞斯达假日酒店选择举行。这些目的是研究有关脂质（主要是脂肪酸（FA）和脂蛋白如何被大脑吸收和利用的脂肪的当前知识状态，以提供一个论坛，以充分互相交流，以互相交流，并在各种背景的参与者之间进行大量的思想和信息，并确定未来研究领域。研讨会主题将包括：跨大脑膜的FA和脂质运输；多不饱和FA（PUFA）的脑代谢，重点是埃卡丁素的生理功能；神经元和神经元膜中二十六烯酸（DHA）的功能以及DHA和其他PUFA在神经系统疾病中的作用；脂质和脂蛋白在过氧化物酶体疾病以及阿尔茨海默氏病中的作用。对机制的持续分歧和无调，所有细胞在整个质膜上运输FA都无法清楚地理解FA如何进入大脑，在这种过程中，由于存在血脑屏障而进一步使这一过程更加复杂。澄清大脑FA的运输和利用机制至关重要，既了解正常的大脑发育和功能，以及对人类神经退行性疾病的诊断和治疗，其中一些疾病可能适合非侵入性的饮食疗法。这次会议之所以及时，是因为a）由于最近建立了几个新的大型中心，大脑研究有巨大的动力，b）生物化学，生物物理学，遗传学，神经影像学和营养的进步导致了专业化和信息爆炸。我们建议，可以通过将研究人员和临床医生聚集在这个广泛的学科中，可以巩固和增强新的见解，这将催化新信息在人类疾病的诊断和治疗中的应用。会议的拟议格式在强调其上是独一无二的 公开讨论这些问题，其含义和自卑，而不是关于教学的演示。预期的结果包括新假设的出现以及建立整合不同学科的新合作。在2000年3月，我们以前的会议以类似的目标，在参与者，与会者和赞助商的眼中取得了非常成功。整个程序，包括谈判，海报，讨论和未来研究的建议，都发表在J. Mol的双重问题上。 Neurosci。已致力于发布拟议会议的诉讼。