Brain Uptake and Utilization of Fatty Acids and Lipids

大脑对脂肪酸和脂质的摄取和利用

• 批准号: 6838021
• 负责人: Paul A. WATKINS
• 金额: $ 2万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838021
• 关键词: blood lipoprotein; brain metabolism; fatty acids; lipid transport; lipids; meeting /conference /symposium; nervous system disorder; travel

DESCRIPTION (provided by applicant) A scientific meeting "Brain Uptake and Utilization of Fatty Acids, Lipids and Lipoproteins: Applications to Neurological Disorders (An International Workshop)" to be held at the Bethesda Holiday Inn Select, October 7-9, 2004, is proposed. The objectives are to examine the current state of knowledge of how lipids, primarily fatty acids (FA), and lipoproteins are taken up and utilized by the brain, to provide a forum for ample interchange of ideas and information between participants of diverse backgrounds, and to identify areas for future research. Workshop topics will include: FA and lipid transport across membranes in the brain; brain metabolism of polyunsaturated FA (PUFA) with emphasis on the physiological functions of eicosenoids; functions of docosahexaenoic acid (DHA) in neurons and neuronal membranes and the roles of DHA and other PUFA in neurological diseases; and roles of lipids and lipoproteins in peroxisomal disorders and in Alzheimer's disease. Continuing disagreement and contreversy over mechanism(s) by which all cells transport FA across the plasma membrane precludes a clear understanding of how FA enter the brain, where this process is further complicated by the presence of the blood-brain barrier. It is vital to clarify brain FA transport and utilization mechanisms, both understanding normal brain development and function and for the diagnosis and therapy of human neurodegenerative diseases, some of which may be amenable to non-invasive, dietary therapy. This conference is timely because a) there is tremendous impetus for brain research with the recent establishment of several new large centers, and b) advances in biochemistry, biophysics, genetics, neuroimaging, and nutrition have led to specialization and an information explosion. We propose that new insights can be consolidated and enhanced by bringing together investigators and clinicians from this wide range of disciplines which will catalyze application of new information to the diagnosis and treatment of human disease. The proposed format of the conference is unique in its emphasis on open discussions of the issues, their implications and contreversies rather than on didactic presentation. Expected outcomes include emergence of new hypotheses and establishment of new collaborations that integrate different disciplines. Our previous conference in March 2000, with similar objectives, was highly successful in the eyes of participants, attendees, and sponsors. The entire proceedings, including talks, posters, discussions, and recommendations for future research were published in a double issue of J. Mol. Neurosci., which has committed to publish the proceedings of the proposed meeting.

介绍(申请人提供)拟于2004年10月7日至9日在贝塞斯达假日酒店精选酒店举办一次名为“大脑对脂肪酸、脂类和脂蛋白的吸收和利用：应用于神经疾病(国际研讨会)”的科学会议。目的是研究大脑如何吸收和利用脂质，主要是脂肪酸(FA)和脂蛋白的知识现状，为不同背景的参与者提供一个充分交流思想和信息的论坛，并确定未来研究的领域。研讨会的主题将包括：脂肪酸和脑膜间的脂质转运；多不饱和脂肪酸(PUFA)的大脑代谢，重点是二十碳烯类化合物的生理功能；二十二碳六烯酸(DHA)在神经元和神经细胞膜中的功能以及DHA和其他多不饱和脂肪酸在神经系统疾病中的作用；以及脂质和脂蛋白在过氧化体疾病和阿尔茨海默病中的作用。所有细胞通过质膜运输FA的机制持续存在分歧和混乱(S)，这使得我们无法清楚地了解FA是如何进入大脑的，而这一过程因血脑屏障的存在而进一步复杂化。阐明脑FA的转运和利用机制，对于了解大脑的正常发育和功能，以及对人类神经退行性疾病的诊断和治疗至关重要，其中一些疾病可能适合非侵入性的饮食治疗。这次会议是及时的，因为a)随着最近几个新的大型中心的建立，大脑研究得到了巨大的推动，以及b)生物化学、生物物理学、遗传学、神经成像和营养学的进步导致了专业化和信息爆炸。我们建议，通过将来自这一广泛学科的研究人员和临床医生聚集在一起，可以巩固和加强新的见解，这将催化将新信息应用于人类疾病的诊断和治疗。拟议的会议形式的独特之处在于它强调 开诚布公地讨论问题、它们的影响和冲突，而不是说教式的陈述。预期结果包括出现新的假设和建立整合不同学科的新合作。我们上一次会议在2000年3月举行，目标相似，在与会者、与会者和赞助商看来非常成功。整个会议过程，包括演讲、海报、讨论和对未来研究的建议，都发表在J·莫尔的双期杂志上。Neurosci.，该公司已承诺公布拟议中的会议记录。