Brain Uptake and Utilization of Fatty Acids and Lipids

大脑对脂肪酸和脂质的摄取和利用

• 批准号: 6838021
• 负责人: Paul A. WATKINS
• 金额: $ 2万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838021
• 关键词: blood lipoprotein; brain metabolism; fatty acids; lipid transport; lipids; meeting /conference /symposium; nervous system disorder; travel

DESCRIPTION (provided by applicant) A scientific meeting "Brain Uptake and Utilization of Fatty Acids, Lipids and Lipoproteins: Applications to Neurological Disorders (An International Workshop)" to be held at the Bethesda Holiday Inn Select, October 7-9, 2004, is proposed. The objectives are to examine the current state of knowledge of how lipids, primarily fatty acids (FA), and lipoproteins are taken up and utilized by the brain, to provide a forum for ample interchange of ideas and information between participants of diverse backgrounds, and to identify areas for future research. Workshop topics will include: FA and lipid transport across membranes in the brain; brain metabolism of polyunsaturated FA (PUFA) with emphasis on the physiological functions of eicosenoids; functions of docosahexaenoic acid (DHA) in neurons and neuronal membranes and the roles of DHA and other PUFA in neurological diseases; and roles of lipids and lipoproteins in peroxisomal disorders and in Alzheimer's disease. Continuing disagreement and contreversy over mechanism(s) by which all cells transport FA across the plasma membrane precludes a clear understanding of how FA enter the brain, where this process is further complicated by the presence of the blood-brain barrier. It is vital to clarify brain FA transport and utilization mechanisms, both understanding normal brain development and function and for the diagnosis and therapy of human neurodegenerative diseases, some of which may be amenable to non-invasive, dietary therapy. This conference is timely because a) there is tremendous impetus for brain research with the recent establishment of several new large centers, and b) advances in biochemistry, biophysics, genetics, neuroimaging, and nutrition have led to specialization and an information explosion. We propose that new insights can be consolidated and enhanced by bringing together investigators and clinicians from this wide range of disciplines which will catalyze application of new information to the diagnosis and treatment of human disease. The proposed format of the conference is unique in its emphasis on open discussions of the issues, their implications and contreversies rather than on didactic presentation. Expected outcomes include emergence of new hypotheses and establishment of new collaborations that integrate different disciplines. Our previous conference in March 2000, with similar objectives, was highly successful in the eyes of participants, attendees, and sponsors. The entire proceedings, including talks, posters, discussions, and recommendations for future research were published in a double issue of J. Mol. Neurosci., which has committed to publish the proceedings of the proposed meeting.

描述（由申请人提供）建议于2004年10月7-9日在贝塞斯达假日酒店选择举行科学会议“脂肪酸、脂质和脂蛋白的脑摄取和利用：对神经疾病的应用（国际研讨会）”。其目的是研究脂质，主要是脂肪酸（FA）和脂蛋白是如何被大脑吸收和利用的知识的现状，为不同背景的参与者之间的思想和信息的充分交流提供一个论坛，并确定未来的研究领域。讲习班的主题将包括：FA和脂质在大脑中跨膜转运;多不饱和FA（PUFA）的大脑代谢，重点是类二十烷酸的生理功能;二十二碳六烯酸（DHA）在神经元和神经元膜中的功能以及DHA和其他PUFA在神经系统疾病中的作用;脂质和脂蛋白在过氧化物酶体障碍和阿尔茨海默病中的作用。关于所有细胞转运FA穿过质膜的机制的持续分歧和争论阻碍了对FA如何进入脑的清楚理解，其中该过程因血脑屏障的存在而进一步复杂化。这是至关重要的，以澄清脑FA的运输和利用机制，无论是了解正常的大脑发育和功能，并为人类神经退行性疾病的诊断和治疗，其中一些可能是适合于非侵入性，饮食治疗。这次会议是及时的，因为a）随着最近几个新的大型中心的建立，大脑研究有巨大的推动力，B）生物化学，生物物理学，遗传学，神经成像和营养学的进步导致了专业化和信息爆炸。我们建议，新的见解可以巩固和加强汇集来自这一广泛学科的研究人员和临床医生，这将促进新信息的应用，以诊断和治疗人类疾病。拟议的会议形式的独特之处在于它强调 公开讨论问题及其影响和矛盾，而不是说教式的陈述。预期成果包括出现新的假设和建立新的合作，整合不同学科。我们在2000年3月举行的上一次会议，具有类似的目标，在与会者、与会者和赞助商的眼中非常成功。整个过程，包括谈话，海报，讨论和对未来研究的建议发表在J. Mol的双刊上。神经科学，该委员会已承诺公布该拟议会议的议事录。