Scientific & Clinical Symposium on Tourette Syndrome

描述(申请人提供)：多发性抽动症(TS)是一种以运动和发声痉挛为特征的神经行为障碍。抽搐开始于童年，随着时间的推移，病情会起伏不定。TS可能与相当大的痛苦，以及社会、学业和职业损害有关。一旦被认为是罕见的，TS的患病率目前估计为0.8%。TS的确切原因尚不清楚，其病因涉及遗传和环境因素。在过去的四年中，TS的研究大幅增加，临床护理方面的重要进展也是如此。为将于2004年6月25日至27日在克利夫兰临床基金会举行的第四届抽动症国际科学和临床研讨会提供部分资金。应该指出的是，抽动症协会(TSA)与NIMH和NINDS共同主办了之前三次关于抽动症的国际科学和临床研讨会。第一次是在1981年，紧随其后的是10年后的1991年和1999年。这些研讨会已经成为更新基础和临床研究人员当前研究成果的中心论坛。本次研讨会还将为未来的TS研究工作和临床护理设定议程。2004年召开第四次研讨会既及时又重要。自从1999年的上一次研讨会以来，我们看到了TS科学出版物的大幅增加，TS研究资金的增加，以及这种疾病的临床管理的进步。新的科学发现既与TS的生物学基础有关，也与临床护理的新方法和改进方法有关。赞助组织TSA为TS研究的快速发展做出了巨大贡献，更重要的是，它的传播也是如此。运输安全管理局有一个非常成功的研究奖励计划。自1984年以来，运输安全管理局已为252名调查人员提供了总计830万美元的资金。许多将在拟议的研讨会上提出的新研究成果直接源于过去或现在的TSA资助和大型合作研究财团在遗传学、神经成像、临床试验和行为科学方面的积极促进。运输安全管理局有一个广泛的议程来传播研究成果。第四届国际科学和临床研讨会是一项有计划的努力的一部分，目的是确定当前的研究进展，在科学界传播它们，并建立基础和临床科学家网络。

DESCRIPTION (provided by applicant): Tourette Syndrome (TS) is a neurobehavioral disorder characterized by motor and vocal tics. Tics begin in childhood, and wax and wane in severity over time. TS can be associated with considerable distress, and social, academic and vocational impairment. Once considered rare, the prevalence of TS is currently estimated to be 0.8%. The exact cause of TS is unknown with both genetic and environmental factors implicated in its etiology. Research in TS has increased dramatically over the past four years, as have important advances in clinical care. Funding is requested for partial support of the 4th International Scientific & Clinical Symposium on Tourette Syndrome to be held June 25-27, 2004 at the Cleveland Clinic Foundation. It should be noted that the Tourette Syndrome Association (TSA) co-sponsored with the NIMH and NINDS the three previous International Scientific and Clinical Symposia on Tourette Syndrome. The first was in 1981, followed a decade later in 1991 and again in 1999. These symposia have served as the central forum for updating basic and clinical researchers in current research findings. This symposium will also set the agenda for future TS research efforts and clinical care. Convening the 4th Symposium in 2004 is both timely and important. Since the last symposium in 1999 we have seen a substantial increase in TS scientific publications, TS research funding, as well as advances in clinical management of this disorder. The new scientific findings are relevant to both the biological underpinnings of TS as well as to new and refined approaches to clinical care. The sponsoring organization, the TSA, has contributed greatly to the rapid advances in TS research and importantly, its dissemination. TSA has a very successful research award program. Since 1984 the TSA has funded 252 investigators for a total 8.3 million dollars. Many of the new research findings to be presented at the proposed Symposium result directly from past or current TSA-funding and active facilitation of large collaborative research consortia in genetics, neuroimaging, clinical trials and the behavioral sciences. The TSA has a broad agenda for the dissemination of research findings. The 4th International Scientific and Clinical Symposium is part of a planned effort to identify current research advances, disseminate them within the scientific community, and establish networks of basic and clinical scientists.