Soft Drinks, Milk and Obesity in Chilean Children

软饮料、牛奶与智利儿童的肥胖

• 批准号: 6734061
• 负责人: DAVID S LUDWIG
• 金额: $ 4.03万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6734061
• 关键词: South America; beverages; blood tests; body composition; body weight; calcium flux; caloric dietary content; clinical research; clinical trials; dietary carbohydrates; dietary constituent; disease /disorder prevention /control; human subject; middle childhood (6-11); milk; nutrient intake activity; nutrition related tag; obesity; outcomes research; photon absorptiometry; public health; statistics /biometry; urinalysis; weight control; weight gain

DESCRIPTION (provided by applicant) The prevalence of obesity has risen dramatically among children in the U.S. and throughout the world since the 1960s. Many factors are thought to have contributed to the epidemic of pediatric obesity. One factor that has received increasing attention is consumption of sugar-sweetened beverages. Feeding studies suggest physiological mechanisms by which sugar in liquid form may be less satiating than other foods. An observational study found total energy consumption to be greater among children who consume sugar-sweetened beverages compared to non-consumes. Short-term interventional studies report increasing energy intake and body weight in subjects given sugar-sweetened beverages compared to non-caloric beverages. Our preliminary data found that the risk for becoming obese increased by about 60% in middle school children for every additional serving per day of sugar-sweetened beverage consumed. The Specific aim of the parent grant is to determine how diet quality and body weight change after reducing consumption of sugar-sweetened beverage consumption in high school students in the U.S. The purpose of the present application is to extend this aim to an even higher risk population using a potentially more power intervention. Specifically, we seek to conduct a 4-month clinical trial involving 96 children ages 8 to 11 years in Chile, a developing nation characterized as undergoing a "nutrition transition." The subjects, selected for current sugar-sweetened soft drink consumption, will be randomly assigned to intervention or control groups. The intervention group will be encouraged to substitute milk products for soft-drinks; to facilitate this dietary change, a variety of milk products will be delivered to subjects' homes on a weekly basis. Clinical endpoints include changes in dietary quality, body weight, adiposity by DEXA-scan and measures of calcium homeostasis. A successful outcome of this study would provide 1) novel insights into the effects of diet on body weight regulation; 2) foundations for an inexpensive approach to the prevention of obesity and related complications in children, growing public health problems throughout the developing world. This research will be done primarily in Chile at INTA in collaboration with Professor Cecilia Albala as an extension of NIH grant# 1R01 DK63554 (dates 9/30/02 to 9/29/04).

描述（由申请人提供） 自1960年代以来，肥胖症的患病率在美国以及世界各地的全世界都显着增长。人们认为许多因素有助于小儿肥胖的流行。受到越来越多的关注的一个因素是消耗糖饮料。喂养研究表明，与其他食物相比，液态糖的糖分可能较少的生理机制。一项观察性研究发现，与非货物相比，食用糖粉饮料的儿童的总能量消耗更大。短期介入研究报告说，与非过滤饮料相比，给予糖饮料的受试者的能量摄入和体重增加。我们的初步数据发现，中学儿童的肥胖风险增加了约60％，每天食用每份糖甜饮料。父母赠款的具体目的是确定在美国高中学生减少食用糖粉饮料消耗后如何改变饮食质量和体重，目前应用的目的是将此目标扩展到使用潜在的电力干预措施的更高风险人群。具体而言，我们试图进行为期4个月的临床试验，其中涉及智利8至11岁的96名儿童，一个发展中国家是一个经历“营养过渡”的发展中国家。这些受试者被选为当前糖含糖的软饮料消耗，将随机分配给干预或对照组。将鼓励干预组将牛奶产品代替软饮。为了促进这种饮食变化，每周都会将各种牛奶产品交付给受试者的房屋。临床终点包括饮食质量的变化，体重，Dexa-Scan的肥胖以及钙稳态的措施。这项研究的成功结果将提供1）对饮食对体重调节的影响的新颖见解； 2）一种廉价方法预防儿童肥胖和相关并发症的基础，在整个发展中国家中越来越多。这项研究将主要在INTA与Cecilia Albala教授合作，作为NIH赠款＃1R01 DK63554（日期9/30/02至9/29/04）的延伸。