Workshop on BioIron in Thalassemia, Sickle Cell Disease and Hemochromatosis

生物铁治疗地中海贫血、镰状细胞病和血色病研讨会

• 批准号: 6702966
• 负责人: ELIZABETH C THEIL
• 金额: $ 2.55万
• 依托单位: CHILDREN'S HOSPITAL & RES CTR AT OAKLAND
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-15 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6702966
• 关键词: homeostasis; iron disorder; sickle cell anemia; thalassemia; travel; workshop

DESCRIPTION (provided by applicant): Biolron, the biology and chemistry of iron in medicine, nutrition and agriculture is a rapidly growing field indicated by the founding of a new Society, IBIS, the International Biolron Society. Discoveries of new genes, new genetic diseases, the demonstrated lethality from gene deletion and the recognition of the complexity and novelty required to safely use iron and oxygen at the same time have all led to the explosion of research in Biolron. Iron malabsorption and transfusional iron overload link the research of the Biolron Groups in Northern California with the strong foci of basic and clinical Biolron research in Hemochromatosis in Southern California, Oregon and Utah. Translational interactions between basic and clinical research in the disease-related research areas are developing within the SCD/'l'halassemia or Hemochromatosis communities, but connections between them are few. Moreover, collaborations that do develop within each community of scientists often are unable to provide opportunities for interactions among junior and senior researchers between collaborative groups. A workshop is proposed to develop new collaborations between disease-specialists, all of whom are involved with iron overload from either hypertransfusion or malabsorption. By bringing groups together with relatively high geographic concentrations that have unusual strength in Biolron research in either Hemochromatosis or Sickle Cell Disease/Thalassemia, new types of collaborations and progress can be expected to emerge from the exchange of information through lectures, posters and informal discussion. In addition, interactions between members of collaborative groups at all stages of professional development will be facilitated, since relatively small travel distances allow junior scientists to attend. The proposed format will facilitate both vertical and horizontal interactions among researchers, to enhance interactions for both basic and clinical researchers at all levels of professional development. Further, integration of research on the two different types of iron overload-hypertransfusion and malabsorption, will be facilitated. Outcomes: Improved collaborative research because of inter-group interactions at multiple levels of professional development. Fuller understanding of iron homeostasis in Thalassemia, Sickle Cell Disease and Hemochromatosis and improved disease management strategies can be expected.

描述(由申请人提供)： Biolron，铁在医药、营养和农业中的生物和化学是一个快速增长的领域，一个新的学会IBIS的成立，即国际Biolron协会的成立。新基因、新基因疾病的发现，基因缺失带来的致命性证明，以及人们对同时安全使用铁和氧气所需的复杂性和新颖性的认识，都导致了Biolron研究的爆炸性增长。铁吸收不良和输血铁过载将北加州Biolron小组的研究与南加州、俄勒冈州和犹他州血色病基础和临床Biolron研究的重点联系在一起。在疾病相关研究领域的基础和临床研究之间的翻译互动正在SCD/‘L’半贫血或血色病社区内发展，但它们之间的联系很少。此外，每个科学家社区内确实发展起来的合作往往无法为初级和高级研究人员之间的合作小组之间的互动提供机会。 有人提议举办一次研讨会，以发展疾病专家之间的新合作，这些专家都与因过度输血或吸收不良而导致的铁超载有关。通过将在血液色素沉着症或镰刀细胞病/地中海贫血方面具有不同寻常优势的Biolron研究中相对较高的地理集中度的小组聚集在一起，通过讲座、海报和非正式讨论交流信息，预计将出现新型的合作和进展。此外，将促进协作小组成员在专业发展的所有阶段之间的互动，因为相对较小的旅行距离允许初级科学家参加。 拟议的格式将促进研究人员之间的垂直和水平互动，以加强基础和临床研究人员在所有专业发展水平上的互动。此外，将促进对两种不同类型的铁超载--过度输血和吸收不良--的研究的整合。 结果：由于小组之间在多个专业发展水平上的互动，改善了合作研究。更全面地了解地中海贫血、镰刀细胞病和血色素沉着症中的铁稳态，并改进疾病管理策略是可以期待的。