Workshop on BioIron in Thalassemia, Sickle Cell Disease and Hemochromatosis

生物铁治疗地中海贫血、镰状细胞病和血色病研讨会

• 批准号: 6702966
• 负责人: ELIZABETH C THEIL
• 金额: $ 2.55万
• 依托单位: CHILDREN'S HOSPITAL & RES CTR AT OAKLAND
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-15 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6702966
• 关键词: homeostasis; iron disorder; sickle cell anemia; thalassemia; travel; workshop

DESCRIPTION (provided by applicant): Biolron, the biology and chemistry of iron in medicine, nutrition and agriculture is a rapidly growing field indicated by the founding of a new Society, IBIS, the International Biolron Society. Discoveries of new genes, new genetic diseases, the demonstrated lethality from gene deletion and the recognition of the complexity and novelty required to safely use iron and oxygen at the same time have all led to the explosion of research in Biolron. Iron malabsorption and transfusional iron overload link the research of the Biolron Groups in Northern California with the strong foci of basic and clinical Biolron research in Hemochromatosis in Southern California, Oregon and Utah. Translational interactions between basic and clinical research in the disease-related research areas are developing within the SCD/'l'halassemia or Hemochromatosis communities, but connections between them are few. Moreover, collaborations that do develop within each community of scientists often are unable to provide opportunities for interactions among junior and senior researchers between collaborative groups. A workshop is proposed to develop new collaborations between disease-specialists, all of whom are involved with iron overload from either hypertransfusion or malabsorption. By bringing groups together with relatively high geographic concentrations that have unusual strength in Biolron research in either Hemochromatosis or Sickle Cell Disease/Thalassemia, new types of collaborations and progress can be expected to emerge from the exchange of information through lectures, posters and informal discussion. In addition, interactions between members of collaborative groups at all stages of professional development will be facilitated, since relatively small travel distances allow junior scientists to attend. The proposed format will facilitate both vertical and horizontal interactions among researchers, to enhance interactions for both basic and clinical researchers at all levels of professional development. Further, integration of research on the two different types of iron overload-hypertransfusion and malabsorption, will be facilitated. Outcomes: Improved collaborative research because of inter-group interactions at multiple levels of professional development. Fuller understanding of iron homeostasis in Thalassemia, Sickle Cell Disease and Hemochromatosis and improved disease management strategies can be expected.

描述（由申请人提供）： Biolron（铁在医学、营养和农业领域的生物学和化学）是一个快速发展的领域，新学会 IBIS（国际 Biolron 学会）的成立表明了这一领域的发展。新基因、新遗传疾病的发现、基因删除所证实的致命性以及对同时安全使用铁和氧所需的复杂性和新颖性的认识，都导致了 Biolron 研究的爆炸式增长。铁吸收不良和输血铁过载将北加州 Biolron 小组的研究与南加州、俄勒冈州和犹他州血色素沉着病基础和临床 Biolron 研究的重点联系起来。疾病相关研究领域的基础研究和临床研究之间的转化相互作用正在 SCD/'l'地中海贫血或血色素沉着症群体中发展，但它们之间的联系很少。此外，每个科学家群体内确实发展的合作往往无法为合作小组之间的初级和高级研究人员之间的互动提供机会。 建议举办一个研讨会，以在疾病专家之间开展新的合作，所有这些专家都因过度输血或吸收不良而导致铁超负荷。通过将具有相对较高地理集中度且在血色素沉着症或镰状细胞病/地中海贫血研究中具有非凡优势的团体聚集在一起，可以预期通过讲座、海报和非正式讨论的信息交流会出现新型合作和进展。此外，由于相对较短的旅行距离允许初级科学家参加，因此将促进专业发展各个阶段的合作小组成员之间的互动。 拟议的格式将促进研究人员之间的纵向和横向互动，以加强基础和临床研究人员在各个专业发展水平上的互动。此外，将促进对两种不同类型的铁超载——过度输血和吸收不良的研究的整合。 结果：由于专业发展的多个层面上的群体间互动，改进了协作研究。有望对地中海贫血、镰状细胞病和血色素沉着症的铁稳态有更全面的了解，并改进疾病管理策略。