Workshop on BioIron in Thalassemia, Sickle Cell Disease and Hemochromatosis

描述（由申请人提供）： Biolron，医学，营养和农业中铁的生物学和化学，是一个快速发展的领域，由一个新的学会IBIS，国际Biolron学会的成立所表明。新基因的发现，新的遗传疾病，基因缺失的致命性以及对同时安全使用铁和氧所需的复杂性和新奇的认识，都导致了Biolron研究的爆炸式增长。铁吸收不良和输血铁过载将北方加州的Biolron研究组与南方加州、俄勒冈州和犹他州的基础和临床Biolron血色素沉着症研究的重点联系起来。基础和临床研究在疾病相关的研究领域之间的转化相互作用正在SCD/'l'盐贫血或血色病社区内发展，但它们之间的联系很少。此外，在每个科学家社区内发展的合作往往无法为合作小组之间的初级和高级研究人员提供互动的机会。 一个研讨会，建议发展新的疾病专家之间的合作，所有这些都涉及到铁超载从输血过多或吸收不良。通过将具有相对较高地理集中度的团体聚集在一起，这些团体在Biolron的血色病或镰状细胞病/地中海贫血研究中具有不同寻常的实力，可以预期通过讲座，海报和非正式讨论交流信息将出现新型合作和进展。此外，还将促进协作小组成员在专业发展各个阶段的互动，因为旅行距离相对较短，年轻科学家可以参加。 拟议的格式将促进研究人员之间的纵向和横向互动，以加强基础和临床研究人员在专业发展的各个层面的互动。此外，整合研究的两种不同类型的铁超负荷-输血过多和吸收不良，将促进。 结果：由于在专业发展的多个层面上的组间互动，改进了合作研究。对地中海贫血、镰状细胞病和血色素沉着症的铁稳态有更全面的了解，并有望改善疾病管理策略。

DESCRIPTION (provided by applicant): Biolron, the biology and chemistry of iron in medicine, nutrition and agriculture is a rapidly growing field indicated by the founding of a new Society, IBIS, the International Biolron Society. Discoveries of new genes, new genetic diseases, the demonstrated lethality from gene deletion and the recognition of the complexity and novelty required to safely use iron and oxygen at the same time have all led to the explosion of research in Biolron. Iron malabsorption and transfusional iron overload link the research of the Biolron Groups in Northern California with the strong foci of basic and clinical Biolron research in Hemochromatosis in Southern California, Oregon and Utah. Translational interactions between basic and clinical research in the disease-related research areas are developing within the SCD/'l'halassemia or Hemochromatosis communities, but connections between them are few. Moreover, collaborations that do develop within each community of scientists often are unable to provide opportunities for interactions among junior and senior researchers between collaborative groups. A workshop is proposed to develop new collaborations between disease-specialists, all of whom are involved with iron overload from either hypertransfusion or malabsorption. By bringing groups together with relatively high geographic concentrations that have unusual strength in Biolron research in either Hemochromatosis or Sickle Cell Disease/Thalassemia, new types of collaborations and progress can be expected to emerge from the exchange of information through lectures, posters and informal discussion. In addition, interactions between members of collaborative groups at all stages of professional development will be facilitated, since relatively small travel distances allow junior scientists to attend. The proposed format will facilitate both vertical and horizontal interactions among researchers, to enhance interactions for both basic and clinical researchers at all levels of professional development. Further, integration of research on the two different types of iron overload-hypertransfusion and malabsorption, will be facilitated. Outcomes: Improved collaborative research because of inter-group interactions at multiple levels of professional development. Fuller understanding of iron homeostasis in Thalassemia, Sickle Cell Disease and Hemochromatosis and improved disease management strategies can be expected.