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3 DIMENSIONAL STRUCTURE OF IRE IN FERRITIN MRNA, STUDIED BY NMR SPECTROSCOPY

3 DIMENSIONAL STRUCTURE OF IRE IN FERRITIN MRNA, STUDIED BY NMR SPECTROSCOPY
通过核磁共振波谱研究铁蛋白 mRNA 中 IRE 的三维结构
批准号：
6309021
负责人：
ELIZABETH C THEIL
金额：
$2.74万
依托单位：
UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-02-01 至 2002-01-14
来源：
https://reporter.nih.gov/project-details/6309021
关键词：
Chordata biomedical resource biotechnology hematology liver nucleic acids nutrition nutrition related tag technology /technique

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中文摘要
翻译
SIR提供l -胺-胍- 13C， N2；15毫克
英文摘要
The SIR provided L-AMinine-guanido- 13C, "N2; 15mg 'C,'N RNA; 1.2g 13C, "N RNA; 292mg 13C, "N RNA; 320mg "C, "N RNA; 560mg The IRE cis element in eukaryotic mRNA is highly conserved and has a characterized specific regulator protein. Our studies of function and structure, using site-directed mutagenesis and cleavage by shape-selective transition metal complexes as structure probes, indicate a folded structure with possibly unusual tertiary features. Our preliminary NMR spectroscopy shows that the IRE sequence (a 30 mer) forms a single conformer in solution which facilitates the structure analysis. The use of 13C- and 15N-enriched ribonucleotides, uniformly labelled or otherwise, are crucial to the NMR study.
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