Workshop on Biolron in Thalassemia & Sickle Cell Disease

描述（由申请人提供）： Biolron，研究健康和疾病中铁稳态的分子和细胞基础，是一个快速发展的领域，也是转化研究的沃土。几个改变铁稳态的基因，如镰状细胞病和地中海贫血症，几乎在半个世纪前就被定义了，而其他改变铁稳态的新基因仍在发现中，例如用于铁摄取的DMT 1，用于铁排出的线粒体铁蛋白和ferroportin以及用于血色病的HFE。新领域的重要性是最近成立的IBIS，国际生物研究学会。 CHORI（奥克兰儿童医院研究所）Biolron研究中心正在赞助一个关于Biolron健康和疾病的研讨会，将一小群资深科学家和医生与在Biolron领域工作的年轻科学家和实习生聚集在一起，这些领域与镰状细胞病，地中海贫血，缺铁和铁螯合的新方面有关。奥克兰儿童医院在血液学/免疫学方面的Biolron研究和博士后培训项目中有着不同寻常的关注。奥克兰儿童医院有大量的镰状细胞病和地中海贫血症输血项目和血液学研究员项目的患者。讲习班有三个目标： 1-加强基础研究与临床研究的结合; 2-发展和加强合作; 3-拓宽Biolron研究实习生（学生和博士后研究员）在更狭窄的个人基础或临床研究领域之外的知识。 研讨会的成果将促进Biolron研究在镰状细胞病和地中海贫血领域的发展，提高对铁营养和螯合作用对这两种疾病影响的认识，并促进基础和临床研究向临床的转移。

DESCRIPTION (provided by applicant): Biolron, the study of the molecular and cellular basis of iron homeostasis in health and disease, is a rapidly expanding field and a fertile ground for translational research. Several of the genes which alter iron homeostasis, such as Sickle Cell Disease and the Thalassemias were defined almost half a century ago, whereas other new genes that alter iron homeostasis are still being discovered, e.g. DMT1 for iron uptake, mitochondrial ferritin and ferroportin for iron exit and HFE for hemochromatosis. The importance of the new field is the recent founding of IBIS, the International Society for Biolron Research. The CHORI (Children's Hospital Oakland Research Institute) Center for Biolron Research is sponsoring a Workshop on Biolron in Health and Disease to bring together a small group of Senior Scientists and Physicians with Junior Scientists and Trainees working in the area of Biolron related to Sickle Cell Disease, Thalassemia, novel aspects of iron deficiency and iron chelation. CHORI has an unusually strong focus in Biolron Research and Postdoctoral Training Program in Hematology/Immunology.Children's Hospital Oakland has large numbers of patients in transfusion programs for Sickle Cell Disease and Thalassemia and a Hematology Fellows Program. The workshop has three goals: 1-Sharpen the focus on coupling basic and clinical research; 2-Develop and strengthen collaborations; 3-Broaden knowledge of Trainees in Biolron research (Students and Postdoctoral Fellows) outside their more narrow individual basic or clinical research areas. The results of the workshop will enhance the development of Biolron Research in the areas of Sickle Cell Disease and Thalassemia, increase awareness of impact of iron nutrition and chelation on the two diseases, and facilitate the transfer of basic and clinical research to the clinic.