Workshop on Biolron in Thalassemia & Sickle Cell Disease

描述(由申请人提供)： Biolron是研究健康和疾病中铁稳态的分子和细胞基础的学科，是一个迅速扩展的领域，也是翻译研究的沃土。几个改变铁稳态的基因，如镰刀细胞病和地中海贫血，在近半个世纪前就被定义了，而其他一些改变铁稳态的新基因仍在被发现，例如与铁摄取有关的DMT1，与铁退出有关的线粒体铁蛋白和铁蛋白，与血色素沉着有关的HFe。这个新领域的重要性在于最近IBIS的成立，即国际生物圈研究学会。 CHORI(儿童医院奥克兰研究所)Biolron研究中心正在赞助一个关于Biolron在健康和疾病中的研讨会，将一小群资深科学家和医生与初级科学家和受训人员聚集在与镰刀细胞疾病、地中海贫血、缺铁和铁络合相关的Biolron领域。CHORI非常专注于血液学/免疫学方面的Biolron研究和博士后培训计划。奥克兰儿童医院有大量患者参加镰状细胞病和地中海贫血的输血计划，以及血液学研究员计划。研讨会有三个目标： 1--突出基础研究与临床研究相结合； 2-发展和加强合作； 3-拓宽Biolron研究实习生(学生和博士后研究员)在其更狭窄的个人基础或临床研究领域之外的知识。 研讨会的成果将促进Biolron Research在镰状细胞病和地中海贫血领域的发展，提高人们对铁营养和螯合对这两种疾病影响的认识，并促进基础和临床研究转移到临床。

DESCRIPTION (provided by applicant): Biolron, the study of the molecular and cellular basis of iron homeostasis in health and disease, is a rapidly expanding field and a fertile ground for translational research. Several of the genes which alter iron homeostasis, such as Sickle Cell Disease and the Thalassemias were defined almost half a century ago, whereas other new genes that alter iron homeostasis are still being discovered, e.g. DMT1 for iron uptake, mitochondrial ferritin and ferroportin for iron exit and HFE for hemochromatosis. The importance of the new field is the recent founding of IBIS, the International Society for Biolron Research. The CHORI (Children's Hospital Oakland Research Institute) Center for Biolron Research is sponsoring a Workshop on Biolron in Health and Disease to bring together a small group of Senior Scientists and Physicians with Junior Scientists and Trainees working in the area of Biolron related to Sickle Cell Disease, Thalassemia, novel aspects of iron deficiency and iron chelation. CHORI has an unusually strong focus in Biolron Research and Postdoctoral Training Program in Hematology/Immunology.Children's Hospital Oakland has large numbers of patients in transfusion programs for Sickle Cell Disease and Thalassemia and a Hematology Fellows Program. The workshop has three goals: 1-Sharpen the focus on coupling basic and clinical research; 2-Develop and strengthen collaborations; 3-Broaden knowledge of Trainees in Biolron research (Students and Postdoctoral Fellows) outside their more narrow individual basic or clinical research areas. The results of the workshop will enhance the development of Biolron Research in the areas of Sickle Cell Disease and Thalassemia, increase awareness of impact of iron nutrition and chelation on the two diseases, and facilitate the transfer of basic and clinical research to the clinic.