Particulate Air Pollution and Acute Ischemic Stroke

空气颗粒物污染与急性缺血性中风

• 批准号: 6935790
• 负责人: GREGORY A WELLENIUS
• 金额: $ 4.74万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-16 至 2007-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6935790
• 关键词: acute disease /disorder; air pollution; cardiovascular disorder epidemiology; cardiovascular disorder risk; cerebral ischemia /hypoxia; clinical research; data collection methodology /evaluation; disease /disorder etiology; environmental stressor; human data; meta analysis; particle; pollutant interaction; postdoctoral investigator; stroke; transient ischemic attack

DESCRIPTION (provided by applicant): Stroke is a leading cause of long-term disability and the third leading cause of death in the US. The identification of triggers of stroke is of significant public health interest. Short-term increases in particulate air pollution may precipitate acute ischemic stroke, but previous findings have been inconsistent. This proposal will apply case-crossover methods to the study of patients hospitalized with a diagnosis of acute ischemic stroke. Specifically, we will test the hypotheses that: short-term increases in ambient particle levels can trigger acute ischemic stroke; the magnitude of this effect will be greater than previously observed when accurate information on time of symptom onset is used; and the effect of particulate matter will vary by the etiologic subtype of stroke with the greatest increase in risk to be observed in those patients with atherothrombotic and lacunar strokes. These hypotheses will be tested in patient populations with complimentary strengths.

描述（由申请人提供）：中风是美国长期残疾的主要原因，也是第三大死亡原因。识别中风的触发因素具有重大的公共卫生意义。空气颗粒污染的短期增加可能会加速急性缺血性中风，但以前的研究结果并不一致。该提案将病例交叉方法应用于诊断为急性缺血性卒中住院患者的研究。具体而言，我们将检验以下假设：环境颗粒物水平的短期增加可触发急性缺血性卒中;当使用症状发作时间的准确信息时，这种影响的程度将大于先前观察到的影响;颗粒物的影响将因卒中的病因亚型而异，在动脉粥样硬化血栓形成和腔隙性卒中患者中观察到的风险增加最大。这些假设将在具有互补优势的患者人群中进行检验。