MECHANISMS OF AIR POLLUTION HEALTH EFFECTS IN SUBJECTS WITH HEART FAILURE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 充血性心力衰竭患者的住院率极高。流行病学研究表明，环境空气污染的短期增加与该人群住院风险的增加有关，但这种影响的机制尚未被调查。因此，我们将在一组充血性心力衰竭患者中进行一项前瞻性、重复测量的研究，以评估空气颗粒物污染影响自主神经功能、炎症和血管内皮功能的机制。这些机制已经在许多正常和易感人群中进行了评估，但从未专门在充血性心力衰竭患者中进行过评估。这项初步研究的目标是：a)证明拟议研究的可行性，b)改进我们的研究设计，c)改进统计能力和样本量的计算。了解潜在的机制可能会导致新的预防策略、新的治疗方法或改善空气质量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hospitalization rates among patients with congestive heart failure are extremely high. Epidemiologic studies suggest that short-term increases in ambient air pollution are associated with increased risk of hospitalization in this population, but the mechanisms of this effect have not been investigated. Therefore, we will conduct a prospective, repeated-measures study to evaluate the mechanisms by which particulate air pollution affects autonomic function, inflammation, and vascular endothelial function in a cohort of patients with congestive heart failure. These mechanisms have been evaluated in a number of normal and susceptible populations, but never specifically in subjects with congestive heart failure. The goals of this pilot study are to: a) demonstrate the feasibility of the proposed study, b) refine our study design, and c) refine calculations for statistical power and sample size. Understanding the underlying mechanisms may lead to new preventative strategies, new treatments, or improved air quality.