CARDIOVASCULAR PHENOTYPING IN MICE

小鼠心血管表型分析

• 批准号: 6846333
• 负责人: ROBERT M WEISS
• 金额: $ 13.5万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6846333
• 关键词: aging; bioimaging /biomedical imaging; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; disease /disorder onset; echocardiography; heart catheterization; laboratory mouse; method development; myocardium disorder; neoplasm /cancer blood supply; neoplasm /cancer diagnosis; phenotype; ultrasonography

DESCRIPTION (provided by applicant): This Award will provide support for the establishment and operation of a core facility for mouse cardiovascular phenotyping. It will also support three projects with implications for aging research: 1) adult-onset cardiomyopathy in mice; 2) age-induced placental insufficiency in mice; and 3) functional tumor vasculogenic mimicry. The application includes specific plans to mentor young investigators who select careers in translational cardiovascular research. Specific long-term career goals: 1) Operate an internationally recognized cardiovascular mouse phenotyping core facility; 2) advance the understanding of the cellular basis of heritable dilated cardiomyopathy, and develop diagnostic and therapeutic modalities with the potential for clinical application; 3) determine the nature and magnitude of impairment of maternal-placental circulation in murine disease states which recapitulate important clinical conditions, and develop therapeutic strategies which have potential for clinical application; 4) apply newfound knowledge about the function of tumor vasculogenic mimicry channels toward improved cancer diagnosis and treatment; and 5) develop and implement a training program in translational mouse cardiovascular research, dedicated toward fostering the careers of future independent investigators. These goals will be pursued by application of current methods and development of new methods for investigation of mouse cardiovascular function in vivo. The project will initially rely on ultrasonography and cardiac catheterization to achieve its Specific Aims. During the course of the Award, new methods for cardiovascular studies in mice will be tested and implemented. Ultimately, the information gained by these studies in mice will form the foundation for the development of novel and feasible advances in the diagnosis and treatment of patients with cardiovascular disorders.

描述（由申请人提供）： 该奖项将为小鼠心血管表型分析核心设施的建立和运营提供支持。 它还将支持三个对衰老研究具有影响的项目：1）小鼠成年发病的心肌病； 2）年龄引起的小鼠胎盘功能不全； 3）功能性肿瘤血管生成拟态。 该申请包括指导选择从事转化心血管研究的年轻研究人员的具体计划。 具体的长期职业目标： 1）运营国际认可的心血管小鼠表型核心设施； 2）增进对遗传性扩张型心肌病细胞基础的理解，开发具有临床应用潜力的诊断和治疗方式； 3）确定小鼠疾病状态下母体胎盘循环受损的性质和程度，概括重要的临床状况，并制定具有临床应用潜力的治疗策略； 4）应用有关肿瘤血管生成拟态通道功能的新知识来改善癌症诊断和治疗； 5) 制定并实施转化小鼠心血管研究培训计划，致力于培养未来独立研究人员的职业生涯。 这些目标将通过应用现有方法和开发新方法来研究小鼠体内心血管功能来实现。 该项目最初将依靠超声检查和心导管插入术来实现其具体目标。 在颁奖期间，将测试和实施小鼠心血管研究的新方法。 最终，这些小鼠研究获得的信息将为心血管疾病患者的诊断和治疗方面取得新颖且可行的进展奠定基础。