Research Ultrasound Imaging Upgrades

研究超声成像升级

• 批准号: 7784169
• 负责人: ROBERT M WEISS
• 金额: $ 20万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-28 至 2011-01-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7784169
• 关键词: Animals; Architecture; Archives; Cardiac; Cardiomyopathies; Cardiovascular Physiology; Cardiovascular system; Charge; Clinical; Color; Computer Hardware; Computer software; Contract Services; Data; Disease; Disease model; Doppler velocimetry; Equipment; Event; Failure; Funding; Funding Applicant; Future; Generic Drugs; Genetic; Heart Valves; Housing; Human; Human Resources; Image; Image Analysis; Imagery; Inherited; Iowa; Lead; Malignant Neoplasms; Morbidity - disease rate; Mus; Myopathy; Phenotype; Physiological; Pre-Eclampsia; Research; Resolution; Rodent; Services; Structure; System; Trust; Ultrasonography; United States National Institutes of Health; Universities; Vendor; Wages; clinically relevant; cost; design; fetal; human disease; improved; instrument; interest; meetings; mortality; open source; public health relevance; waiver

DESCRIPTION (provided by applicant): Funds are requested to upgrade the ultrasound imaging capabilities of The Cardiovascular Phenotype Core at the University of Iowa. The Core was founded with NIH support in 2002, and has completed over 9,000 research ultrasound imaging studies in rodents with clinically relevant models of diseases such as cardiomyopathy, cancer, inherited diseases of muscle, and toxemia of pregnancy. The workhorse instrument in the Core, a Philips Sonos 5500 clinical imager adapted for rodent research, is obsolete. The entire platform has been discontinued, and some components are no longer serviceable by the vendor. The requested instrument is a VisualSonics Vevo 2100 imager, operating on a platform specifically designed for small animal imaging at very high frame rates. The Vevo 2100 operates probes with spatial resolution up to 4.7-fold higher than existing equipment, which will allow visualization of smaller structures (e.g. heart valves and fetal cardiac chambers) required by Users. The Vevo will provide consistent reliable color Doppler imaging and consistent reliable spectral Doppler velocimetry, neither of which can be trusted with present equipment. The requested Vevo 2100 manages image data using an open-architecture format, which allows data archiving and analysis using standard computer hardware and software. This will replace the present system, which is proprietary, and which is no longer able to be serviced by the vendor in the event of hardware or software failure. Core personnel have confirmed the superiority of the requested instrument by imaging local mice of interest during a demonstration of the instrument within the confines of the Cardiovascular Phenotype Core, and have affirmed that the requested instrument is uniquely capable of meeting the future needs of Users. Core personnel have also confirmed the ability to manage and analyze image data using open-source software and generic hardware. Substantial institutional support for this proposal includes the following commitments: waiver of overhead charges for the Core, assumption of the cost of the service contract, salary support for technical personnel, and trade-in of an existing imager housed in a closed lab, for the purpose of reducing the purchase cost to NIH. PUBLIC HEALTH RELEVANCE: Funding is requested to purchase equipment to image cardiovascular function in rodents which display salient genetic and physiologic features of human disease states. Application of this equipment will lead to improved understanding of the causes and treatments for diseases which cause major morbidity and mortality in humans.

描述（由申请人提供）：资金要求在爱荷华州大学的心血管表型核心的超声成像能力升级。该核心是在NIH的支持下于2002年成立的，已经完成了9,000多项啮齿动物的超声成像研究，这些研究涉及心肌病、癌症、肌肉遗传性疾病和妊娠毒血症等临床相关疾病模型。核心中的主力仪器，一台适用于啮齿动物研究的飞利浦Sonos 5500临床成像仪，已经过时。整个平台已经停产，供应商不再提供某些组件。所要求的仪器是VisualSonics Vevo 2100成像仪，在专为小动物成像设计的平台上以非常高的帧速率运行。Vevo 2100操作探头的空间分辨率比现有设备高4.7倍，这将允许用户所需的较小结构（例如心脏瓣膜和胎儿心腔）的可视化。Vevo将提供一致可靠的彩色多普勒成像和一致可靠的频谱多普勒测速，这两种方法都不能用现有的设备来信任。所要求的Vevo 2100使用开放式架构格式管理图像数据，允许使用标准计算机硬件和软件进行数据存档和分析。这将取代现有的系统，该系统是专有的，一旦硬件或软件发生故障，供应商将无法再提供服务。核心人员已通过在心血管表型核心的范围内演示仪器期间对感兴趣的当地小鼠进行成像，确认了所申请仪器的优越性，并确认所申请仪器能够满足用户的未来需求。核心人员还确认了使用开源软件和通用硬件管理和分析图像数据的能力。 对这一提案的实质性机构支持包括以下承诺：免除核心的间接费用，假设服务合同的费用，技术人员的工资支持，以及对封闭实验室中现有成像仪的折价，以减少NIH的购买成本。 公共卫生相关性：申请资金用于购买设备，对啮齿动物的心血管功能进行成像，这些啮齿动物显示出人类疾病状态的显著遗传和生理特征。这一设备的应用将导致更好地了解导致人类主要发病率和死亡率的疾病的原因和治疗方法。