Research Ultrasound Imaging Upgrades

研究超声成像升级

• 批准号: 7784169
• 负责人: ROBERT M WEISS
• 金额: $ 20万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-28 至 2011-01-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7784169
• 关键词: Animals; Architecture; Archives; Cardiac; Cardiomyopathies; Cardiovascular Physiology; Cardiovascular system; Charge; Clinical; Color; Computer Hardware; Computer software; Contract Services; Data; Disease; Disease model; Doppler velocimetry; Equipment; Event; Failure; Funding; Funding Applicant; Future; Generic Drugs; Genetic; Heart Valves; Housing; Human; Human Resources; Image; Image Analysis; Imagery; Inherited; Iowa; Lead; Malignant Neoplasms; Morbidity - disease rate; Mus; Myopathy; Phenotype; Physiological; Pre-Eclampsia; Research; Resolution; Rodent; Services; Structure; System; Trust; Ultrasonography; United States National Institutes of Health; Universities; Vendor; Wages; clinically relevant; cost; design; fetal; human disease; improved; instrument; interest; meetings; mortality; open source; public health relevance; waiver

DESCRIPTION (provided by applicant): Funds are requested to upgrade the ultrasound imaging capabilities of The Cardiovascular Phenotype Core at the University of Iowa. The Core was founded with NIH support in 2002, and has completed over 9,000 research ultrasound imaging studies in rodents with clinically relevant models of diseases such as cardiomyopathy, cancer, inherited diseases of muscle, and toxemia of pregnancy. The workhorse instrument in the Core, a Philips Sonos 5500 clinical imager adapted for rodent research, is obsolete. The entire platform has been discontinued, and some components are no longer serviceable by the vendor. The requested instrument is a VisualSonics Vevo 2100 imager, operating on a platform specifically designed for small animal imaging at very high frame rates. The Vevo 2100 operates probes with spatial resolution up to 4.7-fold higher than existing equipment, which will allow visualization of smaller structures (e.g. heart valves and fetal cardiac chambers) required by Users. The Vevo will provide consistent reliable color Doppler imaging and consistent reliable spectral Doppler velocimetry, neither of which can be trusted with present equipment. The requested Vevo 2100 manages image data using an open-architecture format, which allows data archiving and analysis using standard computer hardware and software. This will replace the present system, which is proprietary, and which is no longer able to be serviced by the vendor in the event of hardware or software failure. Core personnel have confirmed the superiority of the requested instrument by imaging local mice of interest during a demonstration of the instrument within the confines of the Cardiovascular Phenotype Core, and have affirmed that the requested instrument is uniquely capable of meeting the future needs of Users. Core personnel have also confirmed the ability to manage and analyze image data using open-source software and generic hardware. Substantial institutional support for this proposal includes the following commitments: waiver of overhead charges for the Core, assumption of the cost of the service contract, salary support for technical personnel, and trade-in of an existing imager housed in a closed lab, for the purpose of reducing the purchase cost to NIH. PUBLIC HEALTH RELEVANCE: Funding is requested to purchase equipment to image cardiovascular function in rodents which display salient genetic and physiologic features of human disease states. Application of this equipment will lead to improved understanding of the causes and treatments for diseases which cause major morbidity and mortality in humans.

描述（由申请人提供）：要求资金升级爱荷华大学心血管表型核心的超声成像功能。该核心于2002年以NIH的支持建立，并在具有临床相关疾病模型的啮齿动物（例如心肌病，癌症，癌症遗传性肌肉疾病和妊娠毒血症）中完成了9,000多种研究超声成像研究。核心中的主力仪器是一个适合啮齿动物研究的飞利浦Sonos 5500临床成像仪。整个平台都已停产，供应商不再可以使用某些组件。请求的仪器是Visualsics Vevo 2100成像仪，在专门为小动物成像的平台上运行，以非常高的框架速率。 VEVO 2100的空间分辨率比现有设备高4.7倍，这将允许用户需要可视化较小的结构（例如心脏瓣膜和胎儿心脏室）。 VEVO将提供一致的可靠颜色多普勒成像和一致的可靠光谱多普勒速度测定仪，这两种测定都无法通过当前的设备来信任。请求的VEVO 2100使用开放式结构格式管理图像数据，该格式允许使用标准的计算机硬件和软件进行数据归档和分析。这将取代本专有的当前系统，并且在发生硬件或软件故障的情况下，供应商不再能够为其服务。核心人员已经在心血管表型核心范围内展示该仪器时通过对当地小鼠进行成像，证实了所请求的工具的优势，并确认所请求的仪器具有独特的能力，能够满足用户的未来需求。核心人员还确认了使用开源软件和通用硬件管理和分析图像数据的能力。 对该提案的大量机构支持包括以下承诺：放弃核心的间接费用，假设服务合同的成本，对技术人员的薪水支持以及在封闭实验室中安置的现有成像仪的交易，以减少NIH的购买成本。 公共卫生相关性：要求资金购买设备以在啮齿动物的心血管功能中成像，这些设备表现出人类疾病状态的显着遗传和生理特征。该设备的应用将提高人们对疾病的原因和治疗的理解，这些疾病导致人类的主要发病率和死亡率。