High-Resolution Research Ultrasound

高分辨率研究超声

• 批准号: 8824742
• 负责人: ROBERT M WEISS
• 金额: $ 29.8万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8824742
• 关键词: Animal Housing; Arrhythmia; Cardiomyopathies; Cardiovascular system; Contract Services; Experimental Designs; Faculty; Floor; Funding; Funding Applicant; Heart Valve Diseases; Housing; Human Resources; Hypertension; Image; Institutes; Institution; Iowa; Medicine; Methods; Mus; N.I.H. Research Support; Organ; Phenotype; Productivity; Rattus; Recording of previous events; Research; Research Infrastructure; Research Personnel; Resolution; Scientist; Structure; System; Time; Training; Ultrasonography; United States National Institutes of Health; Universities; Vascular Diseases; Vision; bioimaging; college; cost; imaging system; in vivo; innovation; instrument; novel; operation; pathogen

 DESCRIPTION (provided by applicant): Funds are requested to purchase a VisualSonics Vevo 2100 research ultrasound imaging system for the Cardiovascular Phenotype Core at the University of Iowa. The Core was founded in 2002 with NIH funds. In the time since, the Core has provided about 20,000 imaging studies in mice and rats, and has introduced a number of novel methods for assessment of organ structure and function in vivo. In 2010, a Vevo 2100 system was purchased with NIH funds. Usage of that instrument has exceeded projections by > 50%; reaching 3113 studies in 2013. Recruitment of new NIH-funded faculty, whose research depends on animals housed in a pathogen-free barrier facility, will increase demands on the existing Vevo 2100 system beyond its capacity. Accommodation of new Users, along with existing Users, will incur significant hardship, expense, and compromise of experimental design unless an additional Vevo 2100 system is purchased. This request coincides with the launch of a new paradigm-shifting initiative by the University of Iowa Carver College of Medicine (UICCOM). The requested instrument will be housed and operated in the new Pappajohn Biomedical Discovery Building, which will open in June, 2014, at a cost of $147M. Two whole floors of that building will be devoted to research imaging, managed by the Iowa Institute for Biomedical Imaging (IIBI). Commensurate with this new vision, IIBI will provide state of the art space and infrastructure for the requested instrument without financial encumbrance. UICCOM will fund the instrument's service contract. The Cardiovascular Research Center will provide funds for faculty and technical personnel to operate the instrument. Together, the institution will provide $213,350 per year for operation of the requested instrument alone, in addition to space and infrastructure. The requested instrument will support the research of NIH-funded investigators in the fields of hypertension, vascular disease, cardiac arrhythmia, cardiomyopathy, and valvular heart disease. The Core will build on its track record of innovation and productivity, and on its history of training new imaging scientists.

 描述(由申请者提供)：申请资金为爱荷华大学心血管表型核心购买Visualsonics Vevo 2100研究型超声成像系统。CORE成立于2002年，由美国国立卫生研究院资助。在那之后，Core提供了大约20,000个小鼠和大鼠的成像研究，并引入了许多评估活体器官结构和功能的新方法。2010年，用NIH的资金购买了一台Vevo 2100系统。2013年，该仪器的使用量超过了预期，达到3113项研究。招募新的NIH资助的教员，他们的研究依赖于饲养在无病原体屏障设施中的动物，这将增加对现有Vevo 2100系统的需求，使其超出其能力。如果不购买额外的Vevo 2100系统，容纳新用户和现有用户将会带来巨大的困难、费用和实验设计方面的妥协。这一请求与爱荷华大学卡弗医学院(UICCOM)发起的一项新的范式转变倡议不谋而合。所要求的仪器将安装在新的Pappajohn Biomedical Discovery大楼内并进行操作，该大楼将于2014年6月开放，耗资1.47亿美元。该大楼的两层楼将专门用于研究成像，由爱荷华州生物医学成像研究所(IIBI)管理。与这一新愿景相称的是，IIBI将为所要求的仪器提供最先进的空间和基础设施，而不会产生财务负担。UICCOM将为该仪器的服务合同提供资金。心血管研究中心将为操作该仪器的教职员工和技术人员提供资金。共同努力，该机构将 除空间和基础设施外，每年仅为所要求的仪器的运作提供213 350美元。所要求的仪器将支持NIH资助的研究人员在高血压、血管疾病、心律失常、心肌病和瓣膜心脏病等领域的研究。核心将建立在其创新和生产力的记录，以及其培训新的成像科学家的历史上。

项目成果

Discovery of an Experimental Model of Unicuspid Aortic Valve.

单瓣主动脉瓣实验模型的发现。

• DOI: 10.1161/jaha.117.006908
• 发表时间: 2018
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Weiss,RobertM;Chu,Yi;Brooks,RobertM;Lund,DonaldD;Cheng,Justine;Zimmerman,KathyA;Kafa,MelissaK;Sistla,Phanicharan;Doshi,Hardik;Shao,JianQ;ElAccaoui,RamziN;Otto,CatherineM;Heistad,DonaldD
• 通讯作者: Heistad,DonaldD