CARDIOVASCULAR PHENOTYPING IN MICE

描述（由申请人提供）： 该奖项将为小鼠心血管表型核心设施的建立和运营提供支持。 它还将支持三个对衰老研究有影响的项目：1）小鼠成年期心肌病; 2）小鼠年龄诱导的胎盘功能不全; 3）功能性肿瘤血管生成拟态。 该应用程序包括具体的计划，以指导年轻的研究人员谁选择在转化心血管研究的职业生涯。 具体的长期职业目标：1）运营国际公认的心血管小鼠表型核心设施; 2）推进对遗传性扩张型心肌病细胞基础的理解，并开发具有临床应用潜力的诊断和治疗模式; 3）确定小鼠疾病状态中母体-胎盘循环受损的性质和程度，所述疾病状态概括了重要的临床状况，并开发具有临床应用潜力的治疗策略; 4）将新发现的关于肿瘤血管生成拟态通道功能的知识应用于改善癌症诊断和治疗;以及5）开发和实施转化小鼠心血管研究的培训计划，致力于培养未来独立研究人员的职业生涯。 这些目标将通过应用现有的方法和开发新的方法来研究小鼠体内心血管功能。 该项目最初将依靠超声检查和心导管插入术来实现其特定目标。 在颁奖过程中，将测试和实施小鼠心血管研究的新方法。 最终，这些小鼠研究获得的信息将为心血管疾病患者诊断和治疗方面的新的可行进展的发展奠定基础。

DESCRIPTION (provided by applicant): This Award will provide support for the establishment and operation of a core facility for mouse cardiovascular phenotyping. It will also support three projects with implications for aging research: 1) adult-onset cardiomyopathy in mice; 2) age-induced placental insufficiency in mice; and 3) functional tumor vasculogenic mimicry. The application includes specific plans to mentor young investigators who select careers in translational cardiovascular research. Specific long-term career goals: 1) Operate an internationally recognized cardiovascular mouse phenotyping core facility; 2) advance the understanding of the cellular basis of heritable dilated cardiomyopathy, and develop diagnostic and therapeutic modalities with the potential for clinical application; 3) determine the nature and magnitude of impairment of maternal-placental circulation in murine disease states which recapitulate important clinical conditions, and develop therapeutic strategies which have potential for clinical application; 4) apply newfound knowledge about the function of tumor vasculogenic mimicry channels toward improved cancer diagnosis and treatment; and 5) develop and implement a training program in translational mouse cardiovascular research, dedicated toward fostering the careers of future independent investigators. These goals will be pursued by application of current methods and development of new methods for investigation of mouse cardiovascular function in vivo. The project will initially rely on ultrasonography and cardiac catheterization to achieve its Specific Aims. During the course of the Award, new methods for cardiovascular studies in mice will be tested and implemented. Ultimately, the information gained by these studies in mice will form the foundation for the development of novel and feasible advances in the diagnosis and treatment of patients with cardiovascular disorders.