Psychosocial/Behavioral Intervention in PSD

PSD 的心理社会/行为干预

• 批准号: 7047045
• 负责人: PAMELA H MITCHELL
• 金额: $ 7.78万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7047045
• 关键词: antidepressants; behavior therapy; behavioral /social science research tag; brain disorder chemotherapy; combination therapy; community health services; depression; emotions; functional ability; human subject; human therapy evaluation; medical rehabilitation related tag; mental disorder chemotherapy; nursing intervention; patient oriented research; psychosocial rehabilitation; stroke; stroke therapy

DESCRIPTION (provided by applicant): In March 2002, this study was funded as a randomized controlled trial to test the efficacy of a nurse- delivered brief psychosocial-behavioral intervention on depression and subsequent activity and participation outcomes in stroke survivors who are clinically depressed (1R01NR007755-01A1). The fourth aim of this study is to explore patient characteristics that are most predictive of response to this intervention. This aim was included because of the conflicting literature regarding predictors of post-stroke depression and the almost complete absence of evidence regarding who is most likely to benefit from either drug or nonpharmacologic therapies in PSD. Recent evidence regarding the value of genetic polymorphisms of the SERT gene in predicting both depression and response to SSRI has prompted us to add this characteristic to those already proposed (gender, major or minor depression, severity of stroke, or level of social support, all factors associated with depression in the literature). This supplemental project capitalizes on a continuing collaboration between biobehavioral investigators in the Department of Biobehavioral Nursing & Health Systems and Ruth Kohen, MD. Dr. Kohen is currently conducting an NIH grant to study 5-HT receptors and SERT polymorphisms in an animal model of depression. Early findings in that supplemental study point to the value of the SERT polymorphisms in predicting depression concomitant with a chronic condition and the response of that depression to psychosocial interventions. Thus, this supplement will provide the opportunity to add a new marker that may ultimately have value in terms of predicting responses to drug and non-drug therapies in patients with post-stroke depression (and possibly depression concomitant with other chronic health problems). In addition, the data will provide important descriptive information that could be used to further explore, albeit indirectly, the role of serotonin in post-stroke depression.

描述（由申请人提供）：2002 年 3 月，这项研究作为一项随机对照试验获得资助，旨在测试护士提供的简短心理社会行为干预对临床抑郁症中风幸存者的抑郁症以及随后的活动和参与结果的有效性 (1R01NR007755-01A1)。本研究的第四个目的是探索最能预测对此干预措施反应的患者特征。之所以纳入这一目标，是因为有关中风后抑郁症预测因素的文献相互矛盾，而且几乎完全没有证据表明谁最有可能从 PSD 的药物或非药物治疗中受益。最近关于 SERT 基因的遗传多态性在预测抑郁症和 SSRI 反应中的价值的证据促使我们将这一特征添加到已经提出的特征中（性别、重度或轻度抑郁、中风的严重程度或社会支持水平，所有文献中与抑郁症相关的因素）。该补充项目利用了生物行为护理与健康系统系的生物行为研究人员与医学博士 Ruth Kohen 之间的持续合作。 Kohen 博士目前正在接受 NIH 资助，用于研究抑郁症动物模型中的 5-HT 受体和 SERT 多态性。该补充研究的早期发现指出了 SERT 多态性在预测慢性疾病伴随的抑郁症以及抑郁症对心理社会干预的反应方面的价值。因此，该补充剂将提供添加新标记物的机会，该标记物最终可能在预测中风后抑郁症（以及可能伴有其他慢性健康问题的抑郁症）患者对药物和非药物治疗的反应方面具有价值。此外，这些数据将提供重要的描述性信息，可用于进一步探索（尽管是间接的）血清素在中风后抑郁症中的作用。