Microarray Data Standards and Supporting Applications

描述（由申请人提供）：本申请旨在获得正式资助，为功能基因组学社区提供工具和资源，以使用标准格式和实践来交流他们的数据。我们的组织，微阵列基因表达数据协会（MGED），是一个由生物学家，计算机科学家和数据分析师组成的国际组织，其目标是通过提供共享微阵列和其他大规模生物数据的基础设施和资源来促进和扩展实验科学。该基础设施包括用于交换和注释这些数据的标准，以及为基于这些标准开发数据库和数据采集、管理和分析工具提供公共基础的支持软件。MGED资源（MIAME, MAGE-ML， MAGE-stk和MGED本体）已经被广泛使用，因此该拨款申请寻求资金来改进它们，开发新功能，并为使用MGED资源的研究和计算社区提供可靠的支持。每一个具体目标都至少与另一个目标紧密相连，从而继续密切和协作的工作，这一直是

DESCRIPTION (provided by applicant): This application proposes to obtain formal funding to provide the functional genomics community with tools and resources to use standard formats and practices to communicate their data. Our group, the Microarray Gene Expression Data Society (MGED), is an international organization of biologist, computer scientists and data analysts whose aim is to promote and extend experimental science by providing the infrastructure and resources for sharing microarray and other large-scale biological data. This infrastructure includes standards for exchange and annotation of these data and supporting software that provides a common ground for the development of databases and data acquisition, management and analysis tools based on these standards. MGED resources (MIAME, MAGE-ML, MAGE-stk and the MGED Ontology) are already in widespread use, so this grant application seeks funding to improve them, develop new features and to provide dependable support to the research and computational communities using MGED resources. Each specific aim is closely tied to at least one other aim, continuing the close and collaborative work that has been the hallmark of MGED. In addition, each of the aims will require communication with the larger research community, both to obtain criticism and feedback, as well as to provide access to resources and assistance in using them. All software produced will continue to be freely available under the MIT Open Source license, and co-development by others will be facilitated by frequent software development "jamborees." We propose to extend and improve the MAGE Object Model, develop and disseminate an advanced MAGE software toolkit, research and create data quality metrics for microarray data, extend and communicate ontologies for describing microarray experiments, develop and provide tools for validating documents for MIAME compliance and MAGE formatting and to develop freely available tools that allow us to share data.