3D Printing of custom Dental Shells with the long-term aim to prevent bacterial attachment and promote Enamel Regeneration

3D 打印定制牙壳，长期目标是防止细菌附着并促进牙釉质再生

• 批准号: 2468098
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2468098
• 关键词: 3D; Printing; custom; Dental; Shells

Enamel is the most highly mineralised tooth tissue, showing hardness, whilst being fracture and wear resistant. However, the regular intake of acidic food and drinks as well as mechanical abrasion destruct the enamel's mineral matrix permanently. In the past, numerous studies have attempted to synthetically produce mammal enamel. A major challenge in enamel regeneration is to mimic the hierarchical structure of natural enamel.In this study, a 3D printed individualised tooth shell, which eventually shall resist bacterial attachment and internalise enamel regeneration mediating minerals, is being developed. The tooth shell's geometry is derived from a 3D model of an incisor tooth and manufactured using SLA (Stereolithography). AM (Additive Manufacturing) processes such as SLA, Ink Jet Printing, Two-Photon Polymerization, etc. allow tight control over printed (nano) structures and enable a high degree of individualisation, which is of paramount importance in healthcare applications.

牙釉质是最高度矿化的牙齿组织，显示硬度，同时具有抗断裂性和耐磨性。然而，经常摄入酸性食物和饮料以及机械磨损会永久破坏釉质的矿物基质。在过去，许多研究试图合成哺乳动物的牙釉质。牙釉质再生的一个主要挑战是模仿天然牙釉质的层次结构。在这项研究中，正在开发一种3D打印的个性化牙齿外壳，它最终将抵抗细菌附着并内化介导牙釉质再生的矿物质。牙齿外壳的几何形状来自门牙的3D模型，并使用SLA（立体光刻）制造。AM（增材制造）工艺，如SLA，喷墨印刷，双光子聚合等，可以对印刷（纳米）结构进行严格控制，并实现高度个性化，这在医疗保健应用中至关重要。