Neurofeedback functional MRI

神经反馈功能磁共振成像

• 批准号: 6952802
• 负责人: SEUNG-SCHIK YOO
• 金额: $ 28万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-28 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6952802
• 关键词: assistive device /technology; attention; auditory stimulus; bioengineering /biomedical engineering; biofeedback; bioimaging /biomedical imaging; brain; brain mapping; clinical research; cognition; computer human interaction; functional magnetic resonance imaging; human subject; imagery; learning; neural information processing; neuroregulation; patient oriented research; psychomotor disorders; psychomotor function; technology /technique development

DESCRIPTION (PROVIDED BY APPLICANT): The objective of the proposed research is to develop and implement an fMRI method capable of delivering information on anatomically specific brain activities back to a subject in near real-time as biofeedback, thus enabling neurofeedback. Guided by the information on their own cortical activities, the subjects subsequently learn to gain a level of voluntary control in modulating brain activities of auditory and somatomotor areas using cognitive functions such as attention and imagery. The main hypothesis of this study is that the level of attention to auditory stimulation and the content of motor imagery can be voluntarily controlled by the subjects, thus modulating the activities in auditory and somatomotor areas that are characterized by fMRI. The secondary hypothesis is that biofeedback of regionally specific brain function will assist subjects to achieve a greater degree of modulation compared to subjects without neurofeedback. The tertiary hypothesis is that subjects can retain or further enhance the degree of cortical modulation learned from the initial neurofeedback sessions by mental practice in the absence of additional neurofeedback. We will implement an fMRI method to quantify brain activation, delineate the targeted brain areas-of-interest, and enable quantitative scales of brain activities to be fed back to the subjects in the form of graphical/auditory information. The MR parameters and task paradigm will be optimized by implementing, testing, and modifying the cycle of the experiment on 20 volunteer subjects using an auditory attention task. Upon the completion of implementation, we will apply the neurofeedback fMRI method to 15 healthy volunteer subjects undergoing auditory attention and motor imagery tasks. We will modulate subjects' brain activities, in terms of an increase/decrease in the size of activation and/or blood-oxygenation-level-dependent signal contrast, in primary and secondary auditory areas during passive auditory stimulation by assigning different degrees of attention/distraction to incoming stimuli. The activities in somatomotor areas will be modulated using motor imagery. The efficacy of the neurofeedback approach will be examined by comparing the functional brain mapping data to that obtained from demographically matched subjects who perform the task without the guidance of neurofeedback. We will also examine whether the degree of modulation achieved from the neurofeedback procedures can be consolidated and retained over time by performing the second fMR/session to measure the degree of modulatory changes learned from the initial neurofeedback sessions.

描述(由申请人提供)：拟议研究的目标是开发和实施一种功能磁共振成像方法，能够以生物反馈的形式将解剖上特定的大脑活动的信息近乎实时地传递回受试者，从而实现神经反馈。随后，受试者在自己大脑皮层活动信息的引导下，学会了利用注意力和意象等认知功能，在调节听觉和躯体运动区的大脑活动方面获得一定程度的自愿控制。 本研究的主要假设是听觉刺激的注意水平和运动想象的内容可以由被试自愿控制，从而调节以fMRI为特征的听觉和躯体运动区的活动。第二个假设是，与没有神经反馈的受试者相比，特定区域大脑功能的生物反馈将帮助受试者实现更大程度的调节。第三种假设是，在没有额外神经反馈的情况下，受试者可以通过心理练习保持或进一步增强从最初的神经反馈阶段学到的皮质调制程度。 我们将实施功能磁共振成像方法来量化大脑激活，描绘感兴趣的目标大脑区域，并使大脑活动的量化标度能够以图形/听觉信息的形式反馈给受试者。MR参数和任务范式将通过实施、测试和修改使用听觉注意任务的20名志愿者受试者的实验周期来优化。 实施完成后，我们将把神经反馈功能磁共振成像方法应用于15名正在进行听觉注意和运动想象任务的健康志愿者。我们将通过对传入的刺激分配不同程度的注意力/分心来调节受试者的大脑活动，通过增加/减少激活的大小和/或取决于血氧水平的信号对比度，在被动听觉刺激期间的初级和次级听觉区域。躯体运动区的活动将通过运动想象进行调节。神经反馈方法的有效性将通过将脑功能图数据与人口统计匹配的受试者在没有神经反馈指导的情况下执行任务的数据进行比较来检验。我们还将研究是否可以通过执行第二次FMR/会话来衡量从最初的神经反馈会话中学习到的调制变化的程度，从而巩固和保留从神经反馈过程中获得的调制程度。