Non-invasive Modulation of Brain Function by Focused Ultrasound

通过聚焦超声无创调节脑功能

• 批准号: 8241993
• 负责人: SEUNG-SCHIK YOO
• 金额: $ 22.31万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8241993
• 关键词: Acoustics; Acute; Address; Animal Testing; Animals; Area; Behavior; Biological; Blood - brain barrier anatomy; Blood Vessels; Brain; Brain Mapping; Brain Part; Brain region; Caliber; Data; Deposition; Diagnostic; Dose; Electroencephalography; Electromyography; Environment; FOS gene; Focused Ultrasound Therapy; Frequencies; Functional Magnetic Resonance Imaging; Gene Expression; Human; Image; Individual; Investigation; Light; Magnetic Resonance Imaging; Measures; Mental disorders; Methods; Modality; Modeling; Monitor; Nature; Neurons; Oryctolagus cuniculus; Outcome; Pattern; Penetration; Physiologic pulse; Research; Safety; Signal Transduction; Site; Sonication; Specificity; Surface; Techniques; Testing; Therapeutic; Time; Tissues; Transcranial magnetic stimulation; Ultrasonic Transducer; Visual Cortex; area striata; base; blood oxygen level dependent; brain tissue; clinical application; design; extrastriate visual cortex; magnetic field; millimeter; minimally invasive; nervous system disorder; novel; public health relevance; relating to nervous system; sound; success; tool

DESCRIPTION (provided by applicant): The main objective of the proposed research is to develop a focused ultrasound (FUS) method to reversibly modulate (either elicit or suppress) neural activities of specific brain regions. We will develop a magnetic resonance imaging (MRI)-guided sonication environment, capable of evaluating local brain function using electrophysiological recordings (electroencephalography and electromyography) and real- time functional magnetic resonance imaging (rtfMRI). We will examine sonication parameters and their corresponding modulatory effects based on closed-loop monitoring of the electrophysiological data (EEG and EMG signal magnitude), supported by the level of the blood-oxygenation-level-dependent (BOLD) fMRI signal originating from the targeted brain tissue. Consequently, we will examine the range of sonication parameters which induce reversible suppression of regional cortical activity in the primary visual cortex and elicit excitation of activity in the sensorimotor cortex. The dose (duration)-dependent modulatory effects of FUS and their temporal dynamics will be probed via interleaved acquisition of fMRI and EEG/EMG using a trial-based paradigm design. To probe the safety of the method, immunohistological analysis examining biological effects of the sonication in terms of tissue or vascular damage will be performed at variable time points, covering acute, delayed, and long-term periods after the initial sonication. The ability to non-invasively modulate a specific brain area would enable the study of causal relations between brain activity and behavior, including the investigation of functional connectivity between brain regions. The success of this study will result in the exploration of novel potential therapeutic applications of FUS for numerous neurological and psychiatric disorders. PUBLIC HEALTH RELEVANCE: This study will explore the use of focused ultrasound sound waves to temporarily modulate the function of region-specific brain tissue in a non-invasive manner. The success of the proposed method will offer a diagnostic assessment of how well the different parts of the brain are functionally operated and connected to each other. Apart from its potential utility as a diagnostic tool, the ability to suppress or excite local brain tissue in a controlled manner also offers therapeutic potential in the treatment of various neurological and psychiatric disorders.

描述（由申请人提供）：所提议研究的主要目标是开发一种聚焦超声（FUS）方法来可逆地调节（引发或抑制）特定大脑区域的神经活动。 我们将开发一种磁共振成像（MRI）引导的超声处理环境，能够利用电生理记录（脑电图和肌电图）和实时功能磁共振成像（rtfMRI）评估局部大脑功能。 我们将基于电生理数据（EEG 和 EMG 信号幅度）的闭环监测来检查超声处理参数及其相应的调节效应，并得到源自目标脑组织的血氧水平依赖性 (BOLD) fMRI 信号水平的支持。 因此，我们将检查超声参数的范围，这些参数会引起初级视觉皮层区域皮层活动的可逆抑制并引起感觉运动皮层活动的兴奋。 FUS 的剂量（持续时间）依赖性调节效应及其时间动态将通过基于试验的范式设计交错采集 fMRI 和 EEG/EMG 来探测。 为了探讨该方法的安全性，将在不同的时间点进行免疫组织学分析，以检查超声处理对组织或血管损伤的生物效应，涵盖初始超声处理后的急性期、延迟期和长期期。 非侵入性调节特定大脑区域的能力将使研究大脑活动和行为之间的因果关系成为可能，包括研究大脑区域之间的功能连接。 这项研究的成功将有助于探索 FUS 对多种神经和精神疾病的新的潜在治疗应用。 公共健康相关性：本研究将探索使用聚焦超声波以非侵入性方式临时调节特定区域脑组织的功能。 该方法的成功将为大脑不同部分的功能运作和相互连接程度提供诊断评估。 除了作为诊断工具的潜在用途外，以受控方式抑制或兴奋局部脑组织的能力还为治疗各种神经和精神疾病提供了治疗潜力。

项目成果

Noninvasive transcranial stimulation of rat abducens nerve by focused ultrasound.

• DOI: 10.1016/j.ultrasmedbio.2012.04.023
• 发表时间: 2012-09
• 期刊: ULTRASOUND IN MEDICINE AND BIOLOGY
• 影响因子: 2.9
• 作者: Kim, Hyungmin;Taghados, Seyed Javid;Fischer, Krisztina;Maeng, Lee-So;Park, Shinsuk;Yoo, Seung-Schik
• 通讯作者: Yoo, Seung-Schik

Suppression of EEG visual-evoked potentials in rats through neuromodulatory focused ultrasound.

• DOI: 10.1097/wnr.0000000000000330
• 发表时间: 2015-03-04
• 期刊: Neuroreport
• 影响因子: 1.7
• 作者: Kim H;Park MY;Lee SD;Lee W;Chiu A;Yoo SS
• 通讯作者: Yoo SS

Transcranial focused ultrasound to the thalamus alters anesthesia time in rats.

• DOI: 10.1097/wnr.0b013e32834b2957
• 发表时间: 2011-10-26
• 期刊: Neuroreport
• 影响因子: 1.7
• 作者: Yoo SS;Kim H;Min BK;Franck E;Park S
• 通讯作者: Park S

Focused ultrasound-mediated non-invasive brain stimulation: examination of sonication parameters.

• DOI: 10.1016/j.brs.2014.06.011
• 发表时间: 2014-09
• 期刊: Brain stimulation
• 影响因子: 7.7
• 作者: Kim H;Chiu A;Lee SD;Fischer K;Yoo SS
• 通讯作者: Yoo SS

Non-invasive brain-to-brain interface (BBI): establishing functional links between two brains.

• DOI: 10.1371/journal.pone.0060410
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yoo SS;Kim H;Filandrianos E;Taghados SJ;Park S
• 通讯作者: Park S