Neurofeedback functional MRI

神经反馈功能磁共振成像

• 批准号: 7082827
• 负责人: SEUNG-SCHIK YOO
• 金额: $ 27.35万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-28 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7082827
• 关键词: assistive device /technology; attention; auditory stimulus; bioengineering /biomedical engineering; biofeedback; bioimaging /biomedical imaging; brain; brain mapping; clinical research; cognition; computer human interaction; functional magnetic resonance imaging; human subject; imagery; learning; neural information processing; neuroregulation; patient oriented research; psychomotor disorders; psychomotor function; technology /technique development

DESCRIPTION (PROVIDED BY APPLICANT): The objective of the proposed research is to develop and implement an fMRI method capable of delivering information on anatomically specific brain activities back to a subject in near real-time as biofeedback, thus enabling neurofeedback. Guided by the information on their own cortical activities, the subjects subsequently learn to gain a level of voluntary control in modulating brain activities of auditory and somatomotor areas using cognitive functions such as attention and imagery. The main hypothesis of this study is that the level of attention to auditory stimulation and the content of motor imagery can be voluntarily controlled by the subjects, thus modulating the activities in auditory and somatomotor areas that are characterized by fMRI. The secondary hypothesis is that biofeedback of regionally specific brain function will assist subjects to achieve a greater degree of modulation compared to subjects without neurofeedback. The tertiary hypothesis is that subjects can retain or further enhance the degree of cortical modulation learned from the initial neurofeedback sessions by mental practice in the absence of additional neurofeedback. We will implement an fMRI method to quantify brain activation, delineate the targeted brain areas-of-interest, and enable quantitative scales of brain activities to be fed back to the subjects in the form of graphical/auditory information. The MR parameters and task paradigm will be optimized by implementing, testing, and modifying the cycle of the experiment on 20 volunteer subjects using an auditory attention task. Upon the completion of implementation, we will apply the neurofeedback fMRI method to 15 healthy volunteer subjects undergoing auditory attention and motor imagery tasks. We will modulate subjects' brain activities, in terms of an increase/decrease in the size of activation and/or blood-oxygenation-level-dependent signal contrast, in primary and secondary auditory areas during passive auditory stimulation by assigning different degrees of attention/distraction to incoming stimuli. The activities in somatomotor areas will be modulated using motor imagery. The efficacy of the neurofeedback approach will be examined by comparing the functional brain mapping data to that obtained from demographically matched subjects who perform the task without the guidance of neurofeedback. We will also examine whether the degree of modulation achieved from the neurofeedback procedures can be consolidated and retained over time by performing the second fMR/session to measure the degree of modulatory changes learned from the initial neurofeedback sessions.

描述（由申请人提供）：拟议研究的目标是开发和实施一种功能磁共振成像方法，该方法能够将解剖学上特定的大脑活动信息作为生物反馈近乎实时地传递回受试者，从而实现神经反馈。在自身皮层活动信息的引导下，受试者随后学会利用注意力和意象等认知功能，在调节大脑听觉和躯体运动区域活动方面获得一定程度的自主控制。

项目成果

Functional asymmetry in human primary auditory cortex: identified from longitudinal fMRI study.

人类初级听觉皮层的功能不对称：从纵向功能磁共振成像研究中确定。

• DOI: 10.1016/j.neulet.2005.03.025
• 发表时间: 2005
• 期刊: Neuroscience letters
• 影响因子: 2.5
• 作者: Yoo,Seung-Schik;O'leary,HeatherM;Dickey,ChandleeC;Wei,XingChang;Guttmann,CharlesRG;Park,HyunWook;Panych,LawrenceP
• 通讯作者: Panych,LawrenceP

Application of independent component analysis for the data mining of simultaneous Eeg-fMRI: preliminary experience on sleep onset.

• DOI: 10.1080/00207450902854627
• 发表时间: 2009
• 期刊: The International journal of neuroscience
• 作者: Lee JH;Oh S;Jolesz FA;Park H;Yoo SS
• 通讯作者: Yoo SS

Brain-machine interface via real-time fMRI: preliminary study on thought-controlled robotic arm.

• DOI: 10.1016/j.neulet.2008.11.024
• 发表时间: 2009-01-23
• 期刊: Neuroscience letters
• 影响因子: 2.5
• 作者: Lee JH;Ryu J;Jolesz FA;Cho ZH;Yoo SS
• 通讯作者: Yoo SS

Automated classification of fMRI data employing trial-based imagery tasks.

• DOI: 10.1016/j.media.2009.01.001
• 发表时间: 2009-06
• 期刊: MEDICAL IMAGE ANALYSIS
• 影响因子: 10.9
• 作者: Lee, Jong-Hwan;Marzelli, Matthew;Jolesz, Ferenc A.;Yoo, Seung-Schik
• 通讯作者: Yoo, Seung-Schik

Composite MR Contrast Agents for Conditional Cell-Labeling.

用于条件细胞标记的复合 MR 造影剂。

• DOI: 10.1002/ima.20142
• 发表时间: 2008
• 期刊: International journal of imaging systems and technology
• 影响因子: 3.3
• 作者: Marzelli,Matthew;Fischer,Krisztina;Kim,YoungBeom;Mulkern,RobertV;Yoo,Seung-Schik;Park,Hyunwook;Cho,Zang-Hee
• 通讯作者: Cho,Zang-Hee