MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD

以患者为导向的研究职业发展奖

• 批准号: 6916291
• 负责人: Jean Mueller Thomas
• 金额: $ 13.16万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6916291
• 关键词: attention deficit disorder; behavior test; behavioral /social science research tag; child behavior disorders; child psychology; clinical research; comorbidity; conduct disorder; early experience; human subject; interview; neuropsychology; oppositional defiant disorder; parent offspring interaction; patient oriented research; preschool child (1-5); psychopathology; questionnaires

DESCRIPTION (provided by applicant): The applicant is a child and adolescent psychiatrist with primary appointments at Children's National Medical Center (CNMC) and at The George Washington University School of Medicine (GWUSM). Dr. Thomas has extensive clinical experience in toddler psychiatry. This award will allow her to obtain the training and mentoring to become an independent clinical investigator focusing on disruptive disorders in toddlers. The educational plan includes didactic courses covering the principles and practice of clinical research, statistics, bioinfomatics, research design, and early childhood methodology. The goal of the present proposal is to examine the comorbidity between disruptive and other disorders in early childhood. The principal investigator will focus on two types of comorbidity: disruptive disorders with affective dysregulation, and disruptive disorders with neurodevelopmental difficulties (cognitive, language, motor, and neurobehavioral). The aim of this proposal is to take a first step in distinguishing these two developmental patterns of disruptive behavior with cross-sectional data. First, the PI plans to explore patterns of symptoms to verify that patients can be reliably classified into two forms of disruptive disorders: Affective/Disruptive and Neurodevelopmental/Disruptive. Second, she will test the association between these two groups of toddlers and healthy controls with characteristics of the parent and the parent-child relationship. Data from this study will inform a prospective cohort study that will examine developmental pathways to, and etiology of, early disruptive disorders, and guide strategies for intervention and prevention. These studies are important because children with early disruptive difficulties are at increased risk for continuing extemalizing difficulties, for internalizing and academic difficulties, and for adult psychopathology. This study will be conducted at the Pediatric Clinical Research Center (PCRC) at CNMC, affiliated with the Georgetown University Clinical Research Center (GCRC), and requires heavy use of the three PCRC observation rooms, and the PCRC Biostatistics/Bioinfomatics and Behavioral Phenotyping/Instrument Cores.

描述（由申请人提供）： 申请人是一名儿童和青少年精神科医生，主要在儿童国家医疗中心（CNMC）和乔治华盛顿大学医学院（GWUSM）任职。托马斯博士在幼儿精神病学方面有丰富的临床经验。 该奖项将使她获得培训和指导，成为一名独立的临床研究人员，专注于幼儿的破坏性疾病。 教育计划包括教学课程，涵盖临床研究，统计学，生物信息学，研究设计和幼儿方法的原则和实践。 本研究的目的是探讨儿童早期破坏性精神障碍与其他精神障碍的共病性。 主要研究者将关注两种类型的合并症：情感失调的破坏性障碍和神经发育困难（认知、语言、运动和神经行为）的破坏性障碍。 本建议的目的是采取第一步，区分这两种发展模式的破坏性行为的横截面数据。首先，PI计划探索症状模式，以验证患者可以可靠地分为两种形式的破坏性疾病：情感/破坏性和神经发育/破坏性。 其次，她将测试这两组幼儿和健康对照组与父母和亲子关系特征之间的关联。 这项研究的数据将为一项前瞻性队列研究提供信息，该研究将研究早期破坏性疾病的发展途径和病因，并指导干预和预防策略。 这些研究是重要的，因为儿童与早期破坏性的困难是在不断增加的风险外化的困难，内化和学术困难，并为成人精神病理学。 本研究将在乔治敦大学临床研究中心（GCRC）附属的CNMC儿科临床研究中心（PCRC）进行，需要大量使用三个PCRC观察室以及PCRC生物统计学/生物信息学和行为表型分析/仪器核心。