Patient oriented Research--Colon CA & Cancer Immunology

以患者为导向的研究--Colon CA

• 批准号: 6874525
• 负责人: RANDALL F HOLCOMBE
• 金额: $ 12.7万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-19 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6874525
• 关键词: cadherins; cancer prevention; colon neoplasms; combination cancer therapy; difluoromethylornithine; flow cytometry; fluorouracil; human subject; human therapy evaluation; in situ hybridization; interleukin 2; leucovorin; levamisole; microarray technology; neoplasm /cancer chemotherapy; neoplasm /cancer immunology; neoplasm /cancer immunotherapy; neoplasm /cancer relapse /recurrence; patient oriented research

DESCRIPTION (provided by applicant): This application details the experience, qualifications and short- and long-term plans for the patient-oriented research and mentoring activities of Randall F. Holcombe, MD, Chief of Hematology/Oncology at the University of California, Irvine and Associate Director for Clinical Research of the Chao Family Comprehensive Cancer Center. Since completion of Hematology/Oncology sub-specialty training in 1989, Dr. Holcombe has established an academic career in clinical and translational patient-oriented research involving both clinical and basic investigations in the areas of oncology, immunology and genetics. He has been successful in conducting clinical/translational trials and in obtaining extramural support for these activities. Currently and over the past several years, he has also been active in mentoring beginning clinical investigators. This application for the Midcareer Investigator Award in Patient-Oriented Research will provide support to allow Dr. Holcombe to continue and expand upon these activities. This application will outline proposed research and mentoring activities, institutional support for these activities, and documentation of Dr. Holcombe's commitment to a career in patient-oriented research. This is a second revision of a Midcareer Investigator Award in Patient-Oriented Research (K24) initially submitted 10/1/98, with a first revision submitted 7/1/99. Substantial modifications in response to questions raised in the first summary statement were included in the first revision. While minimal criticisms of the proposal were noted in the second summary statement, additional information that further strengthens the application has been provided in preparation of this second revision.

描述（由申请人提供）：此申请详细介绍了经验， 以患者为导向的资格和短期和长期计划 Randall F. Holcombe医学博士的研究和指导活动 加州大学尔湾分校的血液学/肿瘤学 Chao家族综合癌症中心临床研究主管。 自1989年完成血液学/肿瘤学亚专业训练以来， 霍尔科姆博士已经在临床和翻译领域建立了学术生涯 以患者为导向的研究涉及临床和基本研究 肿瘤学，免疫学和遗传学领域。 他已经成功了 进行临床/翻译试验并获得壁外支持 这些活动。 目前和过去几年，他也 一直积极指导开始临床研究人员。 此应用程序 对于以患者为导向的研究中的中级研究员奖，将提供 支持霍尔科姆博士继续进行这些活动。 该应用程序将概述拟议的研究和指导活动， 这些活动的机构支持，以及 霍尔科姆博士致力于以患者为导向的研究。 这是对中级调查员奖的第二次修订 面向患者的研究（K24）最初提交了10/1/98，首次提交 修订于99年7月1日提交。 回答问题的实质修改 在第一个摘要声明中提出的第一次修订中包括。 在第二个摘要中指出了对该提案的最低批评 声明，进一步加强应用程序的其他信息 在准备第二次修订时提供了。