以患者为导向的研究：Colon CA-猫眼课题宝

以患者为导向的研究：Colon CA

批准号：

7386702

负责人：

RANDALL F HOLCOMBE

金额：

$14.96万

依托单位：

UNIVERSITY OF CALIFORNIA-IRVINE

依托单位国家：

美国

项目类别：

财政年份：

2001

资助国家：

美国

项目状态：

已结题

起止时间：

2001-04-19 至 2011-03-31

来源：

https://reporter.nih.gov/project-details/7386702

关键词：

10q AXIN2 gene Academia Academic Medical Centers Activities of Daily Living Adjuvant Adult Adverse event Affect Agar Agar Gel Electrophoresis Alkaline Phosphatase American Association of Cancer Research American Society of Clinical Oncology American Society of Hematology Amino Acids Anatomy Ancillary Study Animal Model Antibodies Antigen Presentation Antigen Presentation Pathway Antigen-Presenting Cells Antigens Antineoplastic Agents Antioxidants Antisense RNA Apoptosis Apoptotic Appearance Appendix Applications Grants Area Armadillo Repeat Atrial Natriuretic Factor Automobile Driving Award B-Lymphocytes BMP4 Basement membrane Binding Binding Sites Biochemistry Bioflavonoid Biological Biological Assay Biological Markers Biological Models Biological Sciences Biometry Bion Biopsy Biopsy Specimen Biotechnology Blood Blood Circulation Bone Marrow Suppression Boston Brachyury protein Buffers C-terminal CC chemokine receptor 7 CCND1 gene CCND2 gene CCR1 gene CCR5 gene CCR8 gene CD19 gene CD44 gene CD80 gene CMV promoter COL1A1 gene CSF2 gene CTBP1 gene CTBP2 gene CTNNB1 gene CXCR4 gene Cadherins Calcium California Cancer Biology Cancer Center Cancer Etiology Cancer Immunology Science Cancer Patient Cancer Therapy Evaluation Program Cancer cell line Cancerous Capecitabine/Oxaliplatin Case Report Form Categories Cell Count Cell Cycle Proteins Cell Line Cell Lineage Cell Nucleus Cell Proliferation Cell Proliferation Regulation Cell Surface Receptors Cell physiology Cell surface Cells Cellular Assay Cellular Structures Cellular biology Cetuximab Characteristics Chemoprevention Class Classification Clinic Clinical Clinical Investigator Clinical Medicine Clinical Nutrition Clinical Oncology Clinical Protocols Clinical Research Clinical Research Protocols Clinical Treatment Clinical Trials Clinical Trials Design Clinical trial protocol document Coculture Techniques Colon Colon Carcinoma Colonic Neoplasms Colonic Polyps Colonoscopy Colorectal Colorectal Cancer Commit Common Neoplasm Community Health Complement Complementary DNA Complex Comprehensive Cancer Center Condition Confocal Microscopy Connexin 43 Contracts Controlled Environment Correlative Study Cost Effectiveness Analysis Coupling Crabs Culture Media Cultured Cells Cytolysis Cytoplasm Cytoskeleton Cytotoxic Chemotherapy DNA DNA Microarray Chip DNA Microarray format Daily Data Dendritic Cells Depth Descriptive Epidemiology Detection Development Developmental Cell Biology Devices Diagnosis Dietary Assessment Digoxigenin Dimethyl Sulfoxide Discipline Disease Dissection Doctor of Philosophy Documentation Dominant-Negative Mutation Dose Down-Regulation Drug resistance E-Cadherin E250 EP300 gene Early Diagnosis Ecology Economics Ectopic Expression Educational Curriculum Effectiveness Eligibility Determination Embryo Embryonic Development End Point Endothelial Cells Enrollment Environmental Epidemiology Environmental Health Enzymes Epidemiology Epidermal Growth Factor Receptor Epithelial Epithelial Cells Epithelium Etiology Evaluable Disease Evaluation Event Excision Exhibits Experimental Designs Exposure to Extracellular Protein Extramural Activities FGF4 gene FOSL1 gene FRAT1 gene FZD2 gene FZD3 gene FZD4 gene FZD6 gene FZD7 gene FZD9 gene Faculty Family Family member Feedback Fellowship Fellowship Program Flow Cytometry Fluorescence Fluorescence Microscopy Fluorochrome Fluorouracil Fluorouracil/Irinotecan/Leucovorin Calcium Fluorouracil/Leucovorin Calcium Follistatin Formalin Foundations Freezing Fresh Tissue Funding Future GTP-Binding Proteins Gastric Glands Gastric Tissue Gastrins Gastroenterology Gelatinase A Gene Expression Gene Expression Regulation Gene Targeting Genes Genetic Genetic Transcription Genus Cola Germ-Line Mutation Germany Glutathione S-Transferase Goals Grant Granulocyte-Macrophage Colony-Stimulating Factor Grapes Group Meetings Growth Growth Factor HST Oncogene HT29 Cells Hand Head Health Health Care Costs Health Services Hematology Heme Hereditary Nonpolyposis Colorectal Neoplasms Histologic Homeostasis Hour Human Human Resources Hydrolysis ICAM1 gene ID2 gene IL3RA gene ITGAX gene Imagery Immune Immune response Immune system Immunization Immunohistochemistry Immunologics Immunology Immunosuppression In Situ In Situ Hybridization In Vitro Incubated Indium Individual Inflammatory Inflammatory Bowel Diseases Informed Consent Inherited Institutes Instruction Integrin alpha3 Interferon Type II Interferons Intervention Studies Intestinal Mucosa Investigation JUN gene Journals K-Series Research Career Programs Label Laboratories Laboratory Research Laboratory Scientists Laboratory Study Lasers Lead Leadership Length Letters Levamisole Life Expectancy Ligands Localized Disease Location Louisiana Luc Gene Lung MAPK8 gene MHC Class I Genes MHC Class II Genes MSX1 gene MYB gene Maintenance Malignant - descriptor Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of nasopharynx Malignant neoplasm of pancreas Malignant neoplasm of prostate Manufacturer Name Manuscripts Marketing Matrix Metalloproteinases Measurement Measures Mediating Medical Medical Oncology Medical Research Medical Students Medicine Membrane Mentored Clinical Oncology Award Mentored Clinical Scientist Award Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Messenger RNA Metastatic/Recurrent Methodology Methods Microarray Analysis Microbiology Microsatellite Instability Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Minor Modeling Molecular Molecular Analysis Molecular Biology Molecular Genetics Molecular Profiling Monitor Monoclonal Antibodies Morus Mucous Membrane Mus Mutate Mutation NCAM1 gene NOS2A gene Names National Institute of Diabetes and Digestive and Kidney Diseases National Surgical Adjuvant Breast and Bowel Project Natural Killer Cells Neck Neoplasm Metastasis Neutropenia Northern Blotting Nuclear Nucleic Acid Regulatory Sequences Numbers Nurse Practitioners Nurses Nursing Faculty Nutritional Study Nylons Office of the Director Oligonucleotide Primers Oligonucleotide Probes Oncologic Nursing Oncology Nurse Operative Surgical Procedures Organ Orthopedics Oryctolagus cuniculus Outcome Oxidation-Reduction PLAUR gene PPP2R5D gene PTGS2 gene Pathogenesis Pathologic Pathway interactions Patient Care Patient Schedules Patients Pattern Peanuts - dietary Peer Review Perception Peripheral Peripheral Blood Mononuclear Cell Pharmaceutical Preparations Pharmacologic Substance Pharmacology Phase Phase II Clinical Trials Phenotype Phosphotransferases Physicians Pilot Projects Placement Plants Plasmids Play Polymerase Chain Reaction Population Population Group Positioning Attribute Postdoctoral Fellow Pre-study Predisposition Premalignant Preparation Prevention Preventive Probenecid Procedures Process Production Protein Kinase C Protein Overexpression Protein Phosphatase 2A Regulatory Subunit PR53 Proteins Proto-Oncogene Proteins c-jun Proto-Oncogene Proteins c-myb Protocols documentation Public Health Publications Publishing Purpose RNA RNA Probes Range Rate Reader Reagent Receptor Signaling Recombinant DNA Recommendation Recruitment Activity Rectal Cancer Recurrence Refractory Regulation Reporter Reporting Research Research Activity Research Design Research Ethics Committees Research Personnel Research Project Grants Research Proposals Research Training Resources Rest Resveratrol Reverse Transcriptase Polymerase Chain Reaction Review Committee Risk Role Rotation SFRP4 gene Sample Size Sampling Schools Scientist Score Secure Sentinel Sequence Analysis Series Side Signal Pathway Signal Transduction Signaling Molecule Signaling Pathway Gene Simplexvirus Site Skin Slide Small Interfering RNA Societies Solutions Source Southwest Oncology Group Specificity Specimen Staging Staining method Stains Standards of Weights and Measures Stem cells Stomach Stress Students Study Section Subgroup Sulindac Support of Research Surrogate Endpoint Surrogate Markers System T-Lymphocyte TATA Box TCF7L2 gene TP53 gene Techniques Technology Testing Therapeutic Therapeutic Clinical Trial Therapeutic Effect Therapeutic Touch Therapeutic immunosuppression Therapy Clinical Trials Thymidine Kinase Time Tissue Sample Tissues Title Topoisomerase I inhibition Toxic effect Training Training Programs Transcriptional Activation Transfection Translational Research Treatment Effectiveness Tumor Angiogenesis Tumor Antigens Tumor Cell Invasion Tumor Immunity Tumor Tissue Tumor-Derived United States Food and Drug Administration United States National Institutes of Health Universities University of California Irvine Cancer Center Up-Regulation Vaccines Variant Vascular Endothelial Growth Factors Venous blood sampling WNT1 gene WNT10A gene WNT11 gene WNT2 gene WNT2B gene WNT3 gene WNT4 gene WNT5A gene WNT5A protein WNT6 gene WNT7A gene WNT9A gene Wages Week Western Blotting Wnt proteins Work Writing abstracting angiogenesis anticancer research bacteriophage T3 RNA polymerase base beta catenin c-myc Genes cDNA Arrays cancer cell cancer diagnosis cancer epidemiology cancer immunology function cancer prevention cancer research center director cancer type capsule career celecoxib cell growth cell motility chemokine chemokine receptor chemotherapy chiron vaccine cohort colon cancer cell line colon carcinogenesis colonic crypt concept cost cyclooxygenase 2 cytokine day design dietary supplements disorder control dosage epithelial to mesenchymal transition experience extracellular functional genomics gastrointestinal genetic epidemiology human MMP14 protein human NOS2A protein human PPP2R5D protein human SFRP4 protein human WNT10A protein human WNT11 protein human WNT2 protein human WNT2B protein human WNT3 protein human WNT4 protein human WNT6 protein human WNT7A protein human WNT9A protein human study immune function immunoregulation improved in vivo inhibitor/antagonist instructor interest iron metabolism jun Oncogene laser capture microdissection lymph nodes lymphoid enhancer-binding factor 1 mRNA Expression malignant breast neoplasm malignant stomach neoplasm matrigel matrix metalloproteinase 26 medical schools member migration molecular oncology monocyte mutant neoplastic neoplastic cell novel novel strategies novel therapeutics oncology osteosarcoma outcome forecast oxaliplatin patient oriented patient oriented research peripheral blood professor progenitor programs promoter protein activation protein expression proto-oncogene protein kfgf quality assurance receptor receptor expression reconstitution red wine release of sequestered calcium ion into cytoplasm repaired research study response rho slug social statistics success symposium trafficking transcription factor translational clinical trial trend trizol tumor tumor growth tumor immunology tumor progression tumorigenesis type I collagen alpha 1 uncontrolled cell growth vector vector control

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英文摘要

This application is submitted as a competitive renewal of a midcareer investigator award in patient-oriented research (K24CA82450). The PI is Randall F. Holcombe, MD. This application details the experience, qualifications and short- and long-term patient-oriented research plans of Dr. Holcombe, as well as reviews progress during the period of support under the current award. Details about current and planned patient- oriented research is provided. These studies are focused on patient-oriented research in colon cancer and include studies related to the Wnt signaling pathway, elucidation of immunologic events in conjunction with administration of chemotherapy for colon cancer and definition of the mechanisms and potential therapeutic and cancer preventive effects of resveratrol, a naturally occuring compound found in the skin of grapes. Patients with inflammatory bowel disease, having or at high risk for colon cancer, are also studied. An additional clinical trial with laboratory correlative studies, originally designed and written by a mentee hematology-oncology fellow of Dr. Holcombe's involves the treatment of patients with gastric cancer. Mentoring activity over the past 5 years and mentoring plans for the next 5 years are described. The accomplishments of mentees are outlined as are their current activities, espeicially as related to ongoing participation in patient-oriented research. Ongoing mentoring plans include formal coursework, basic/translational research experiences, instruction in the development and implementation of clinical research trials, and hands-on experiences in clinical research. The original goals and objectives of the current award are reviewed and the extent to which these have been achieved is delineated. Documentation of institutional support and justification of the need for continued support through the K24 mechanism is provided.

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