Patient-oriented Research: Colon CA & Cancer Immunology

本申请是以病人为中心的职业生涯中期调查员奖的竞争性续展。 研究(K24CA82450)。私家侦探是马里兰州的兰德尔·F·霍尔科姆。这个应用程序详细介绍了体验， 霍尔科姆博士的资格和以患者为导向的短期和长期研究计划以及综述 在本合同项下的支助期间取得的进展。关于当前和计划中的患者的详细信息- 提供了有针对性的研究。这些研究的重点是以患者为中心的结肠癌和 包括与Wnt信号通路相关的研究，免疫学事件的阐明 结肠癌的化疗给药及其作用机制和可能的治疗方法 白藜芦醇具有预防癌症的作用，白藜芦醇是一种天然存在于葡萄皮中的化合物。 患有炎症性肠病、有结肠癌风险或高风险的患者也被研究。一个 附加临床试验和实验室相关研究，最初由学员设计和编写 霍尔科姆博士的血液学-肿瘤学研究员涉及胃癌患者的治疗。 描述了过去5年的辅导活动和未来5年的辅导计划。这个 受训者的成就以及他们目前的活动，特别是与正在进行的活动有关的成就被概述 参与以病人为中心的研究。正在进行的指导计划包括正式的课程工作， 基础/转化性研究经验，指导临床研究的开发和实施 研究试验，以及临床研究的实践经验。的原定目标和目的 对目前的奖项进行了审查，并说明了实现这些目标的程度。文档 机构支持和需要通过K24机制继续提供支持的理由是 如果是这样的话。

This application is submitted as a competitive renewal of a midcareer investigator award in patient-oriented research (K24CA82450). The PI is Randall F. Holcombe, MD. This application details the experience, qualifications and short- and long-term patient-oriented research plans of Dr. Holcombe, as well as reviews progress during the period of support under the current award. Details about current and planned patient- oriented research is provided. These studies are focused on patient-oriented research in colon cancer and include studies related to the Wnt signaling pathway, elucidation of immunologic events in conjunction with administration of chemotherapy for colon cancer and definition of the mechanisms and potential therapeutic and cancer preventive effects of resveratrol, a naturally occuring compound found in the skin of grapes. Patients with inflammatory bowel disease, having or at high risk for colon cancer, are also studied. An additional clinical trial with laboratory correlative studies, originally designed and written by a mentee hematology-oncology fellow of Dr. Holcombe's involves the treatment of patients with gastric cancer. Mentoring activity over the past 5 years and mentoring plans for the next 5 years are described. The accomplishments of mentees are outlined as are their current activities, espeicially as related to ongoing participation in patient-oriented research. Ongoing mentoring plans include formal coursework, basic/translational research experiences, instruction in the development and implementation of clinical research trials, and hands-on experiences in clinical research. The original goals and objectives of the current award are reviewed and the extent to which these have been achieved is delineated. Documentation of institutional support and justification of the need for continued support through the K24 mechanism is provided.