University of Hawaii Cancer Center CCSG

描述（由申请人提供）：本申请为夏威夷大学癌症中心（UHCC）寻求新的CCSG资助，UHCC是夏威夷州和太平洋地区唯一进行癌症研究的机构。作为世界上健康差距巨大的地区的前哨站，UHCC在为独特的地区人口提供如何预防和治疗癌症的尖端基础，转化和临床研究方面发挥着关键作用。UHCC是新的夏威夷癌症联盟（HCC）的一部分，以及夏威夷的三个主要医院系统。该联盟使UHCC能够开发新的临床项目，并扩大其临床和转化研究，以开发新的诊断和治疗方法。到2017年，HCC机构每年向UHCC承诺220万美元，UHCC从NCI获得2320万美元，从其他同行评审来源获得1800万美元，同行评审拨款总额为4120万美元。UHCC/HCC最近招募了一名新的主任，以及30名额外的教职员工，他们带来了广泛的科学和临床技能。这些新成员帮助UHCC/HCC继续建立和加强其基础科学基础，并大大提高了其加速临床和转化癌症研究的能力。为了加强他们的跨学科和转化研究，三个研究项目（癌症生物学、癌症流行病学和癌症预防与控制）已经重组，以提供更好的重点在他们的研究领域。UHCC的所有项目都由新的主任领导，每个主任都致力于增加项目的活力和互动。此外，规划与评价

DESCRIPTION (provided by applicant): This application seeks renewed CCSG funding for the University of Hawai'i Cancer Center (UHCC), the state of Hawai'i and the Pacific Region's only institution where cancer research is performed. As an outpost in an area of the world with significant health disparities, UHCC serves a critical function in bringing cutting edge basic, translational, and clinical research on how to prevent and treat cancer within reach of the unique regional population. UHCC is part of the new Hawai'i Cancer Consortium (HCC) along with the 3 major hospital systems of Hawai'i. This consortium enables UHCC to develop a new clinical program and expand its clinical and translational research towards the development of new diagnostics and therapies. HCC institutions have committed $2.2 million annually towards UHCC through 2017, and UHCC receives $23.2M from the NCI and $18M from other peer-reviewed sources for a total of $41.2M in overall peer-reviewed grant funding. UHCC/HCC has recently recruited a new Director, along with 30 additional faculty members, who bring with them a broad-spectrum of scientific and clinical skills. These new recruits have helped UHCC/HCC continue to build and strengthen its basic-science foundations and to greatly enhance its ability to accelerate clinical and translational cancer research. To enhance their transdisciplinary and translational research, the three Research Programs (Cancer Biology, Cancer Epidemiology, and Cancer Prevention and Control) have been reorganized to provide a better focus in their areas of research. All Programs at UHCC are led by new Directors, each dedicated to increasing the vitality and interaction of their Programs. In addition, Planning and Evaluation has been restructured to create more opportunities for investigators to interact and stay abreast of opportunities for collaboration. This application requests support for 7 Shared Resources (Analytical Biochemistry, Biostatistics and Informatics, Genomics, Microscopy and Imaging, Nutrition Support, Pathology, and Clinical and Translational Research Services), and one developing Shared Resource (Animal Carcinogenesis). Major additions in research facilities include a new 150,000-sq ft UHCC research building opening in 2012 that will collectively house our growing faculty, as the University of Hawai'i has approved a total of 18 new tenure track positions for UHCC. This application describes continued excellence in basic and translational cancer research, and greatly strengthened clinical research leadership and infrastructure.