PHASE I BIOMARKER STUDY OF DIETARY GRAPE-DERIVED LOW DOSE RESVERATROL FOR COLON

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在这项研究中，我们将直接测试在控制量的其他含白藜芦醇的食物对结肠中Wnt信号传导的背景下，含有特定量的红葡萄的饮食的影响。 这种补充葡萄的饮食提供了低剂量的白藜芦醇以及葡萄中含有的其他潜在活性成分。 参与者将是正常的志愿者，分子研究将在摄入含红葡萄的饮食之前和之后通过有限的柔性乙状结肠镜获得的结肠组织上进行。 将使用不同剂量的葡萄。 这项研究将确定膳食葡萄衍生的低剂量白藜芦醇对Wnt通路相关生物标志物的影响，并提供关于这种营养方法预防结肠癌的实用性的关键信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, we will directly test the impact of a diet containing a specific amount of red grapes in the context of a controlled amount of other resveratrol containing foodstuffs on Wnt signaling in the colon. This grape-supplemented diet provides a low-dose of resveratrol in conjunction with other potentially active components containing within the grapes. Participants will be normal volunteers and molecular studies will be done on colon tissue obtained by a limited flexible sigmoidoscopy before, and after, the red grape-containing diet is ingested. Different dosages of grapes will be utilized. This study will define the effect of dietary grape-derived low dose resveratrol on biomarkers related to the Wnt pathway, and provide critical information as to the utility of this nutritional approach toward colon cancer prevention.