STUDIES OF REGIONAL FAT DISTRIBUTION AND ENERGY BALANCE

区域脂肪分布与能量平衡的研究

• 批准号: 6833543
• 负责人: DAVID S WEIGLE
• 金额: $ 10.13万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6833543
• 关键词: AIDS therapy; HIV infections; adipose tissue; bioenergetics; body composition; clinical research; cortisol; dietary carbohydrates; dietary lipid; gene expression; hormone receptor; human subject; leptin; lipoprotein lipase; nutrition related tag; obesity; peroxisome proliferator activated receptor; weight control

The studies in this application are designed to better understand the regulation of body fat mass and the mechanisms determining body fat distribution in humans. Three Specific Aims are proposed: 1. To determine whether experimentally-induced or spontaneous variations in plasma leptin levels predict subsequent changes in body composition. The protocols employed will also elucidate the mechanism by which high carbohydrate diets induce satiety and weight loss, and the mechanism of involuntary weight loss in the elderly. 2. To examine the relationships among central body fat redistribution, changes in adipogenic gene expression, and atherogenic changes in plasma lipids and insulin sensitivity. The model for this work will be the body fat redistribution that occurs in subjects receiving aggressive antiretroviral therapy for HIV infection. 3. To determine whether changes in uncoupling protein (UCP) gene expression act to attenuate diet-induced changes in body fat mass. This study will use the technology developed for Specific Aim 2 to ascertain whether muscle and fat UCP expression change in parallel with energy expenditure following experimental weight gain and weight loss in human subjects. The applicant has successfully trained several young physician investigators in patient-oriented and basic research, and a plan to continue doing so is presented.

本申请中的研究旨在更好地了解人体体脂量的调节以及决定人体体脂分布的机制。提出了三个具体目标：1。以确定是否实验诱导或自发的血浆瘦素水平的变化预测随后的身体组成的变化。所采用的方案也将阐明高碳水化合物饮食诱导饱腹感和体重减轻的机制，以及老年人非自愿体重减轻的机制。2.研究中心体脂肪再分布、成脂基因表达变化与血脂和胰岛素敏感性致动脉粥样硬化变化之间的关系。这项工作的模型将是在接受积极的抗逆转录病毒治疗艾滋病毒感染的受试者中发生的体脂重新分布。3.确定解偶联蛋白（UCP）基因表达的变化是否能减弱饮食诱导的体脂量变化。本研究将使用为特定目标2开发的技术，以确定在人类受试者实验性体重增加和体重减轻后，肌肉和脂肪UCP表达是否与能量消耗平行变化。申请人已经成功地培训了几个年轻的医生研究人员以病人为导向的基础研究，并提出了一个计划，继续这样做。

项目成果

n3 PUFAs do not affect adipose tissue inflammation in overweight to moderately obese men and women.

• DOI: 10.3945/jn.113.174383
• 发表时间: 2013-08
• 期刊: The Journal of nutrition
• 作者: M. Kratz;J. Kuzma;D. Hagman;B. van Yserloo;C. Matthys;H. Callahan;D. Weigle

Leptin levels are appropriate for body mass index in older men who experience involuntary weight loss.

瘦素水平适合经历非自愿体重减轻的老年男性的体重指数。

• DOI: 10.1046/j.1532-5415.2002.50414.x
• 发表时间: 2002
• 期刊: Journal of the American Geriatrics Society
• 影响因子: 6.3
• 作者: Yukawa,Michi;McCormick,WayneC;Rajan,Suparna;Matsumoto,AlvinM;Wallace,JefferyI;Pearlman,RobertA;Weigle,DavidS
• 通讯作者: Weigle,DavidS

Functional differences in yeast protein disulfide isomerases.

• DOI: 10.1083/jcb.152.3.553
• 发表时间: 2001-02-05
• 期刊: The Journal of cell biology
• 作者: Nørgaard P;Westphal V;Tachibana C;Alsøe L;Holst B;Winther JR
• 通讯作者: Winther JR

A Review of Nutrients and Compounds, Which Promote or Inhibit Intestinal Iron Absorption: Making a Platform for Dietary Measures That Can Reduce Iron Uptake in Patients with Genetic Haemochromatosis.

• DOI: 10.1155/2020/7373498
• 发表时间: 2020
• 期刊: Journal of nutrition and metabolism
• 影响因子: 2.2
• 作者: Milman NT