THE IMPACT OF OMEGA-3-POLYUNSATURATED FATTY ACIDS ON ADIPOSITY HORMONES

OMEGA-3-多不饱和脂肪酸对肥胖激素的影响

• 批准号: 7379337
• 负责人: DAVID S WEIGLE
• 金额: $ 31.09万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379337
• 关键词: IMPACT; OMEGA; POLYUNSATURATED; FATTY; ACIDS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The epidemic of obesity in the US has led many to advocate for a significant reduction in dietary fat intake. However, over-emphasis on this recommendation may lead to an unexpected consequence of reducing the intake of beneficial fatty acids. A number of animal and human studies have shown that a diet rich in w-3-polyunsaturated fatty acids (PUFA) is beneficial because it lowers serum leptin concentrations and body fat mass. These studies have been predominantly done in animals, were of short duration, and have demonstrated diverging effects of PUFA on circulating leptin levels and leptin signaling in the circuate nucleus. There is a paucity of data on the metabolic mechanisms by which high PUFA diets might lead to the reduction of body fat mass in humans. We propose to study the effects of a 3-month ad libitum diet rich in PUFA, and a control diet rich in monounsaturated fatty acids (MUFA), on body weight, fat mass, leptin levels and leptin sensitivity in overweight men and women.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。美国肥胖症的流行导致许多人主张大幅减少膳食脂肪摄入。然而，过分强调这一建议可能会导致减少有益脂肪酸摄入量的意想不到的后果。许多动物和人类研究表明，富含w-3-多不饱和脂肪酸（PUFA）的饮食是有益的，因为它降低了血清瘦素浓度和体脂量。这些研究主要是在动物中进行的，持续时间短，并且已经证明了PUFA对循环瘦素水平和循环核中瘦素信号传导的不同影响。关于高PUFA饮食可能导致人体脂肪量减少的代谢机制的数据很少。我们建议研究3个月的自由采食富含PUFA的饮食和富含单不饱和脂肪酸（MUFA）的对照饮食对超重男性和女性的体重、脂肪量、瘦素水平和瘦素敏感性的影响。