THE IMPACT OF OMEGA-3-POLYUNSATURATED FATTY ACIDS ON ADIPOSITY HORMONES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。美国肥胖症的流行促使许多人倡导大幅减少膳食脂肪的摄入量。然而，过分强调这一建议可能会导致减少有益脂肪酸摄入量的意想不到的后果。许多动物和人体研究表明，富含w-3-多不饱和脂肪酸(PUFA)的饮食是有益的，因为它可以降低血清瘦素浓度和身体脂肪质量。这些研究主要是在动物身上进行的，持续时间较短，并证明了多不饱和脂肪酸对循环瘦素水平和环状核内瘦素信号的不同影响。关于高多不饱和脂肪酸饮食可能导致人体脂肪减少的代谢机制的数据很少。我们建议研究3个月的富含多不饱和脂肪酸(PUFA)的随意饮食和富含单不饱和脂肪酸(MUFA)的对照饮食对超重男性和女性体重、脂肪质量、瘦素水平和瘦素敏感性的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The epidemic of obesity in the US has led many to advocate for a significant reduction in dietary fat intake. However, over-emphasis on this recommendation may lead to an unexpected consequence of reducing the intake of beneficial fatty acids. A number of animal and human studies have shown that a diet rich in w-3-polyunsaturated fatty acids (PUFA) is beneficial because it lowers serum leptin concentrations and body fat mass. These studies have been predominantly done in animals, were of short duration, and have demonstrated diverging effects of PUFA on circulating leptin levels and leptin signaling in the circuate nucleus. There is a paucity of data on the metabolic mechanisms by which high PUFA diets might lead to the reduction of body fat mass in humans. We propose to study the effects of a 3-month ad libitum diet rich in PUFA, and a control diet rich in monounsaturated fatty acids (MUFA), on body weight, fat mass, leptin levels and leptin sensitivity in overweight men and women.