TRAINING PROGRAM IN QUANTITATIVE BIOLOGY AND PHYSIOLOGY

定量生物学和生理学培训计划

• 批准号: 6919142
• 负责人: KENNETH R LUTCHEN
• 金额: $ 20.01万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6919142
• 关键词: TRAINING; PROGRAM; QUANTITATIVE; BIOLOGY; PHYSIOLOGY

EXCEED THE SPACE PROVIDED. There is a need to develop researchers who can identity and approach problems in biology and physiology trom a quantitative, integrative (across biological length scales), and systems perspective. This proposal aims to fill this need by establishing an interdisciplinary Pre-doctoral training program addressing the Systems and Integrative Biology area that will be housed in biomedicalengineering (BME). Our TrainingProgram in Quantitative Biology and Physiology will produce biomedical scientists who understand molecularbiology, cell biology andphysiology simultaneously with a strong technical background to approach biological and physiological problems from a quantitative perspective. We will emphasize quantitative and mathematical modeling techniques that are mechanistic, structurally based, and often ubiquitous across biological scale. Our graduates will acquire the requisite skills, breadth, and experience to branch at all levels (molecular, cell-tissue, organ, complex biodynamics) of a biological or physiological system or process. Our program represents a special opportunity to unite three departments at Boston University: Biomedical Engineering, Biology, and Mathematics; four interdisciplinary research centers; and an interdisciplinary program in MolecularBiology, Cell Biology, and Biochemistry (MCBB). We will establish a curriculum for the trainingprogram that includes rigorous course and lab rotational exposure to: (a) quantitative molecular biology, cell biology, and physiology, and (b) engineering-based biology in four thematic areas: Molecular Biological and Genetic Engineering, Cellular and Tissue Biomechanics and Electrophysiology, Organ and Sensory Systems, and Complex Biodynamics. We will require trainees to conduct thesis research that is interdisciplinary, integrative, quantitative,and linked to experimental data. Finally, we will establish a unique identity for the Quantitative Systems Biomedical Scientists that participate in our program through several interactive components, including a Seminar Series in Quantitative Biology and Physiology, Student-Faculty Science-Curriculum Retreats, Monthly Dinners and Journal Clubs. In summary, our intent is to produce integrated, quantitative, and systems oriented biomedical scientists that will assume leadership positions in the life science communities of academic institutions (e.g., universities and teaching hospitals) and industry. PERFORMANCE SITE ========================================Section End===========================================

超出所提供的空间。 需要培养能够从定量、综合（跨生物长度尺度）和系统的角度识别和处理生物学和生理学问题的研究人员。该提案旨在通过建立一个跨学科的博士前培训计划来满足这一需求，该计划涉及生物医学工程（BME）中的系统和综合生物学领域。我们的定量生物学和生理学培训计划将培养生物医学科学家，他们了解分子生物学、细胞生物学和生理学，同时具有强大的技术背景，可以从定量的角度解决生物和生理问题。我们将强调机械的、基于结构的、并且通常在生物尺度上普遍存在的定量和数学建模技术。我们的毕业生将获得必要的技能、广度和经验，以在生物或生理系统或过程的各个层面（分子、细胞组织、器官、复杂的生物动力学）进行分支。我们的项目代表了一个特殊的机会，可以将波士顿大学的三个系联合起来：生物医学工程、生物学和数学；四个跨学科研究中心；以及分子生物学、细胞生物学和生物化学（MCBB）的跨学科项目。 我们将为培训计划制定课程，其中包括严格的课程和实验室轮流接触：（a）定量分子生物学、细胞生物学和生理学，以及（b）四个主题领域的工程生物学：分子生物学和基因工程、细胞和组织生物力学和电生理学、器官和感觉系统以及复杂生物动力学。我们将要求学员进行跨学科、综合性、定量性、并与实验数据相联系的论文研究。最后，我们将为定量系统生物医学科学家建立一个独特的身份，他们通过几个互动部分参与我们的项目，包括定量生物学和生理学研讨会系列、师生科学课程静修、每月晚宴和期刊俱乐部。总之，我们的目的是培养综合、定量和系统导向的生物医学科学家，他们将在学术机构（例如大学和教学医院）和工业界的生命科学界担任领导职务。表演网站==========================================章节结束===============================================