Facilitating Decision Making in Advanced Cancer Patients

描述（由申请人提供）：改进的癌症全身治疗的开发通常始于转移性疾病患者的临床试验，这些患者的标准方法要么失败，要么预期获益低，要么不存在。这些患者特别脆弱，因为他们的短期病情普遍不佳，缺乏令人鼓舞的标准治疗选择。这种脆弱性，加上实验性治疗的潜在获益和毒性的不确定性，创造了一个独特而困难的医疗决策环境。 我们以前的工作表明，考虑治疗方案的晚期癌症患者，包括与个体患者价值观一致的问题的令人满意的讨论，以及医生对治疗的潜在风险和益处的期望的有效沟通，通常不能满足医疗决策的重要目标。该提案的总体目标是为转移性癌症患者开发一种沟通辅助工具，以促进治疗决策。将开发和测试一个基于网络的交互式工具，用于评估患者的价值观和信息需求，提供有关癌症治疗的教育，并提供沟通技能培训。在患者就诊前，将向咨询医生提供计算机生成的报告，该报告提供有关患者价值观的总结信息、有关共同决策的愿望以及有关如何向他们提供潜在风险和受益信息的细节和性质的期望。本研究的目的是测量这种干预（使用随机临床试验设计）对1）患者对医生咨询的满意度和决策冲突，2）患者对治疗方案潜在获益和副作用的期望，以及3）医患咨询内容的影响。本多中心研究将招募计划接受初次咨询的晚期癌症患者。患者将参加基于网络的调查和教育干预、咨询后调查和3个月随访调查。将对医生咨询的子样本进行录音，并对其内容进行分析。

DESCRIPTION (provided by applicant): The development of improved systemic therapies for cancer generally begins with clinical trials in patients with metastatic disease for whom standard approaches have either failed, have low expectation of benefit, or do not exist. These patients are particularly vulnerable, given their generally poor short-term prognoses and lack of encouraging standard treatment options. This vulnerability, coupled with uncertainty regarding potential benefits and toxicities of experimental therapy, creates a unique and difficult medical decision making context. Our previous work suggests that important goals of medical decision making are not routinely being met for advanced cancer patients considering treatment options, including satisfactory discussion of issues consonant with individual patient values, and effective communication of physician expectations of potential risks and benefits of therapy. The overall goal of this proposal is to develop a communication aid for patients with metastatic cancer to facilitate treatment decision making. An interactive web-based tool that assesses patient values and information needs, provides education about cancer treatment, and provides communication skills training will be developed and tested. A computer-generated report will be provided to the consulting physician before the patient encounter that provides summary information about patient values, wishes regarding shared decision making, and desires regarding the detail and nature of how potential risk and benefit information is presented to them. The aims of this research are to measure the effect of this intervention (using a randomized clinical trial design) on 1) patient satisfaction with the physician consultation, and decisional conflict, 2) patient expectations regarding potential benefits and side effects from treatment options, and 3) content of physician-patient consultation. Patients with advanced cancer who are scheduled for an initial consultation will be recruited for this multi-center study. Patients will participate in a web-based survey and education intervention, post-consultation survey, and 3-month follow up survey. A subsample of physician consultations will be audiotaped and their content analyzed.