Zinc Nutrition and Brain Development in Southern Ethiopia

埃塞俄比亚南部的锌营养与大脑发育

• 批准号: 7122724
• 负责人: K MICHAEL HAMBIDGE
• 金额: $ 5.25万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-28 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7122724
• 关键词: Africa; African; biomarker; brain; clinical research; cognition disorders; developmental disease /disorder; developmental neurobiology; developmental nutrition; dietary trace element; disease /disorder prevention /control; disease /disorder proneness /risk; epidemiology; health disparity; human population study; human subject; metal metabolism; nutrient requirement; nutrition; nutrition related tag; training; urban poverty area; zinc

DESCRIPTION (provided by applicant): The objectives of this proposal are: [1] to develop the necessary resources, including human resources at or/and associated with Debub University, Southern Ethiopia, supported by collaborations with and between the University of Colorado Health Sciences Center and Oklahoma State University, to initiate and sustain a durable research program linking nutrition [micronutrients] and maternal-child brain development and function; [2] to complete pilot studies that will provide an essential cornerstone for the development of a major R01 grant proposal that will be designed to test the following hypotheses: Provision of an optimal quantity of bioavailable zinc during the second and third trimesters of pregnancy and to offspring through the first 2 years will be associated with improved maternal cognitive and behavioral; greater head circumference of neonate [adjusted for gestational age] and improved attention/habituation/intellectual and motor development throughout the first 2 years of life and beyond. These objectives will be achieved by: fully developing a research team in Awassa and associated institutions; an initial planning, consortium-building, needs assessment meeting in Awassa; supporting the development of an IRB with FWA at Debub University; training and cross-training [nutrition and brain function research] in Awassa, Colorado and Oklahoma; pilot testing of tools for studies of brain function in Awassa; pilot nutrition studies including: dietary, biomarker and anthropometrics assessment; assessment of zinc nutritional status, zinc absorption and zinc requirements for this particular population; a second planning meeting to review progress and plan details of R01 proposal; and, finally, the development of the R01 proposal based on the experience and knowledge acquired with this preparatory/pilot R21-supported research.

描述（申请人提供）：本提案的目的是：[1]开发必要的资源，包括在埃塞俄比亚南部的埃布布大学或/和与之相关的人力资源，由科罗拉多大学健康科学中心和俄克拉荷马州州立大学合作支持，发起并维持一项将营养[微量营养素]与母婴大脑发育和功能联系起来的持久研究方案;[2]完成试点研究，为制定主要R 01赠款提案提供必要的基础，该提案旨在测试以下假设：在妊娠的第二和第三个三个月期间以及在前2年内为后代提供最佳量的生物可利用锌将与母亲认知和行为改善、新生儿头围增大[根据胎龄调整]以及在生命的前2年及以后注意力/习惯性/智力和运动发育改善相关。 这些目标将通过以下方式实现：在阿瓦萨和相关机构充分发展一个研究小组;在阿瓦萨举行一次初步规划、联合会建设和需求评估会议;支持在阿瓦萨大学与FWA建立一个IRB;在阿瓦萨、科罗拉多和俄克拉荷马州进行培训和交叉培训[营养和脑功能研究];在阿瓦萨对脑功能研究工具进行试点测试;试验性营养研究，包括：膳食、生物标志物和人体测量学评估;评估该特定人群的锌营养状况、锌吸收和锌需求;第二次计划会议，审查R 01提案的进展和计划细节;最后，根据从R21支持的预备/试验研究中获得的经验和知识，制定R 01提案。

项目成果

Growth and Visual Information Processing in Infants in Southern Ethiopia.

埃塞俄比亚南部婴儿的生长和视觉信息处理。

• DOI: 10.1016/j.appdev.2007.12.003
• 发表时间: 2008
• 期刊: Journal of applied developmental psychology
• 影响因子: 3
• 作者: Kennedy,Tay;Thomas,DavidG;Woltamo,Tesfaye;Abebe,Yewelsew;Hubbs-Tait,Laura;Sykova,Vladimira;Stoecker,BarbaraJ;Hambidge,KMichael
• 通讯作者: Hambidge,KMichael

Hemoglobin, growth, and attention of infants in southern Ethiopia.

埃塞俄比亚南部婴儿的血红蛋白、生长和注意力。

• DOI: 10.1111/j.1467-8624.2011.01596.x
• 发表时间: 2011
• 期刊: Child development
• 影响因子: 4.6
• 作者: Aubuchon-Endsley,NickiL;Grant,StephanieL;Berhanu,Getenesh;Thomas,DavidG;Schrader,SarahE;Eldridge,Devon;Kennedy,Tay;Hambidge,Michael
• 通讯作者: Hambidge,Michael

Infant responsiveness, alertness, haemoglobin and growth in rural Sidama, Ethiopia.

埃塞俄比亚西达马农村地区婴儿的反应能力、警觉性、血红蛋白和生长情况。

• DOI: 10.1111/j.1740-8709.2011.00391.x
• 发表时间: 2013
• 期刊: Maternal & child nutrition
• 影响因子: 3.4
• 作者: Aubuchon-Endsley,NickiL;Grant,StephanieL;Thomas,DavidG;Kennedy,TayS;Berhanu,Getenesh;Stoecker,BarbaraJ;Hubbs-Tait,Laura;Hambidge,KMichael
• 通讯作者: Hambidge,KMichael

Iodine status and cognitive function of women and their five year-old children in rural Sidama, southern Ethiopia.

埃塞俄比亚南部西达马农村妇女及其五岁儿童的碘状况和认知功能。

• 发表时间: 2009
• 期刊: East African journal of public health
• 作者: Bogale,Alemtsehay;Abebe,Yewelsew;Stoecker,BarbaraJ;Abuye,Cherinet;Ketema,Kassu;Hambidge,KMichael
• 通讯作者: Hambidge,KMichael