The Global Network and Preconception Maternal Nutrition
全球网络和孕前孕产妇营养
基本信息
- 批准号:8679038
- 负责人:
- 金额:$ 15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-07-05 至 2018-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAgeAlgorithmsAnthropometryAwarenessBirth WeightBloodChildChild MortalityChild health careChildhoodCollaborationsColoradoCommitCommunicable DiseasesCommunitiesConceptionsCountryDataDevelopmentDietary InterventionEarly InterventionEnrollmentFailureFemaleFolateFoodFutureGoalsGrowthGuatemalaGuatemalanHealthHealth BenefitHealth PersonnelHealth PolicyIncidenceInfantInterventionIronLeadershipLengthLinkLipidsLow Birth Weight InfantLow incomeMentorsMicronutrientsMissionMorbidity - disease rateMothersNeonatalOutcomePerinatal mortality demographicsPlacentaPopulationPostpartum PeriodPregnancyPreventionPrincipal InvestigatorProteinsProtocols documentationPublic HealthRandomizedRegistriesResearchResearch DesignResearch MethodologyResourcesRoleSamplingSecond Pregnancy TrimesterSeveritiesSiteTestingTrainingUltrasonographyUmbilical Cord BloodUniversitiesWeight GainWomanarmbasedata registrydesignefficacy trialempoweredevidence basefetalhuman capitalinclusion criteriainduced pluripotent stem cellinfancyintergenerationalmortalitymother nutritionnutritionoffspringpostnatalprenatalprimary outcomepublic health relevancerandomized trialreproductivesecondary outcome
项目摘要
DESCRIPTION (provided by applicant): Broad Goal: To participate in all collaborative activities relevant to the mission of the Global Network including the development and leadership of Common Network projects as exemplified by Preconception Maternal Nutrition. Study Objective: Determine the public health benefits in resource-poor populations of providing a comprehensive nutrition supplement to women of reproductive age commencing S3 mo. prior to conception (Arm 1, PC) in comparison with starting the same supplement at 12 wk. gestation (Arm 2, PG) or provision of iron/folate alone (Arm 3, IPS). Primary outcomes: (1) length-for-age Z-score (LAZ) at 7 d postpartum; (2) LAZ at 6 mo. of age. Secondary outcomes include: comparing arms for fetal length; birth weight; incidence of low birth weight; incidence of perinata and early infancy (<6 mo.) mortality and severe infectious disease morbidity. Research Design & Methods: Multi-site randomized controlled efficacy trial. Each arm will include 800 women divided equally among sites. The first 100 of each arm in each site to conceive continue interventions <6 mo. postpartum. Inclusion criteria: para 1-2, <26 yr., enrolled through Global Network Maternal Neonatal Health Registry (MNHR); algorithms based on MNHR data to enroll at 12 ¿ 3 mo. post-partum. Arm 1 commences intervention at enrollment; Arms 2 and 3 receive IPS from enrollment with Arm 2 switching to same supplement as Arm 1 at 12 weeks gestation. Intervention provides 100 kcal/d as a lipid-based multi-micronutrient (MMN) product, with increasing energy to 500 kcal/d and protein to 25g/d if BMI <20 or pregnancy weight gain is low. Baseline parental, fetal (ultrasound), birth weight, early neonatal (7 d) and infant anthropometry (3 and 6 mo.); longitudinal maternal blood, subsample cord blood & placenta samples will be collected by trained Network and Health personnel. Mortality and morbidity data will be collected from MNHR. The primary analyses will compare LAZ at 7 days for Arm 1 vs. Arms 2 and 3 controlling for site. The results of this study have potentially profound implications for the impat of nutrition interventions initiated prior to conception, and for the reversibility of adverse intergenerational effects, including linear growth failure.
描述(由申请人提供):广泛目标:参加与全球网络使命有关的所有合作活动,包括发展和领导共同网络项目,如先入为主的产妇营养项目。研究目的:确定从S3mo开始为育龄妇女提供全面营养补充对资源贫乏人群的公共卫生效益。在受孕前(手臂1,PC)与在12周时开始相同的补充相比较。妊娠(第2组,PG)或单独提供铁/叶酸(第3组,IPS)。主要结果:(1)产后7天的Z评分(LAZ);(2)6个月的LAZ。年纪大了。次要结果包括:比较双臂胎儿的长度;出生体重;低出生体重的发生率;围产儿和早期婴儿的发生率(<;6个月)。死亡率和严重传染病发病率。研究设计与方法:多点随机对照疗效试验。每个分支机构将包括800名妇女,平均分布在各个地点。前100个手臂在每个部位构思继续干预<;6mo。产后。纳入标准:第1-2段,26岁,通过全球网络产妇新生儿健康登记(MNHR)登记;基于MNHR数据的算法在12?3个月登记。产后。ARM 1在注册时开始干预;ARM 2和3从注册中获得IPS,ARM 2在怀孕12周时切换到与ARM 1相同的补充剂。干预措施提供100千卡/天作为一种以脂质为基础的多种微量营养素(MMN)产品,如果体重指数和体重增加较低,则将能量增加到500千卡/天,蛋白质增加到25g/d。基线父母、胎儿(超声)、出生体重、早期新生儿(7天)和婴儿人体测量(3和6个月);纵向母血、脐带血和胎盘样本将由训练有素的网络和卫生人员收集。死亡率和发病率数据将从MNHR收集。初步分析将比较ARM 1与ARM 2和ARM 3控制现场的7天LAZ。这项研究的结果对于在受孕前开始的营养干预的影响,以及对包括线性生长障碍在内的不良代际影响的可逆性具有潜在的深远影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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K MICHAEL HAMBIDGE其他文献
K MICHAEL HAMBIDGE的其他文献
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{{ truncateString('K MICHAEL HAMBIDGE', 18)}}的其他基金
The Global Network and Preconception Maternal Nutrition
全球网络和孕前孕产妇营养
- 批准号:
9283186 - 财政年份:2016
- 资助金额:
$ 15万 - 项目类别:
The Global Network and Preconception Maternal Nutrition
全球网络和孕前孕产妇营养
- 批准号:
8519715 - 财政年份:2013
- 资助金额:
$ 15万 - 项目类别:
The Global Network and Preconception Maternal Nutrition
全球网络和孕前孕产妇营养
- 批准号:
9462333 - 财政年份:2013
- 资助金额:
$ 15万 - 项目类别:
The Global Network and Preconception Maternal Nutrition
全球网络和孕前孕产妇营养
- 批准号:
8672665 - 财政年份:2013
- 资助金额:
$ 15万 - 项目类别:
The Global Network and Preconception Maternal Nutrition
全球网络和孕前孕产妇营养
- 批准号:
9063436 - 财政年份:2013
- 资助金额:
$ 15万 - 项目类别:
ESTIMATING HUMAN ZINC PHYSIOLOGICAL ZINC REQUIREMENTS: TESTING A NEW CONCEPT
估算人体锌的生理需求:测试新概念
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Zn & Maternal-Infant Brain Function in S. Ethiopia: Randomized Controlled Trials
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