Zinc Nutrition and Brain Development in Southern Ethiopia

埃塞俄比亚南部的锌营养与大脑发育

• 批准号: 6804085
• 负责人: K MICHAEL HAMBIDGE
• 金额: $ 13.98万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-28 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6804085
• 关键词: Africa; African; biomarker; brain; clinical research; cognition disorders; developmental disease /disorder; developmental neurobiology; developmental nutrition; dietary trace element; disease /disorder prevention /control; disease /disorder proneness /risk; epidemiology; health disparity; human population study; human subject; metal metabolism; nutrient requirement; nutrition; nutrition related tag; training; urban poverty area; zinc

DESCRIPTION (provided by applicant): The objectives of this proposal are: [1] to develop the necessary resources, including human resources at or/and associated with Debub University, Southern Ethiopia, supported by collaborations with and between the University of Colorado Health Sciences Center and Oklahoma State University, to initiate and sustain a durable research program linking nutrition [micronutrients] and maternal-child brain development and function; [2] to complete pilot studies that will provide an essential cornerstone for the development of a major R01 grant proposal that will be designed to test the following hypotheses: Provision of an optimal quantity of bioavailable zinc during the second and third trimesters of pregnancy and to offspring through the first 2 years will be associated with improved maternal cognitive and behavioral; greater head circumference of neonate [adjusted for gestational age] and improved attention/habituation/intellectual and motor development throughout the first 2 years of life and beyond. These objectives will be achieved by: fully developing a research team in Awassa and associated institutions; an initial planning, consortium-building, needs assessment meeting in Awassa; supporting the development of an IRB with FWA at Debub University; training and cross-training [nutrition and brain function research] in Awassa, Colorado and Oklahoma; pilot testing of tools for studies of brain function in Awassa; pilot nutrition studies including: dietary, biomarker and anthropometrics assessment; assessment of zinc nutritional status, zinc absorption and zinc requirements for this particular population; a second planning meeting to review progress and plan details of R01 proposal; and, finally, the development of the R01 proposal based on the experience and knowledge acquired with this preparatory/pilot R21-supported research.

描述（申请人提供）：本提案的目的是：[1]在与科罗拉多大学健康科学中心和俄克拉荷马州之间的合作的支持下，开发必要的资源，包括埃塞俄比亚南部德巴布大学或/和相关的人力资源。州立大学，发起并维持一项将营养[微量营养素]与母婴大脑发育和功能联系起来的持久研究方案;[2]完成试点研究，为制定主要R 01赠款提案提供必要的基础，该提案旨在测试以下假设：在妊娠的第二和第三个三个月期间以及在前2年内为后代提供最佳量的生物可利用锌将与母亲认知和行为改善、新生儿头围增大[根据胎龄调整]以及在生命的前2年及以后注意力/习惯性/智力和运动发育改善相关。 这些目标将通过以下方式实现：在阿瓦萨和相关机构充分发展一个研究小组;在阿瓦萨举行一次初步规划、联合会建设和需求评估会议;支持在阿瓦萨大学与FWA建立一个IRB;在阿瓦萨、科罗拉多和俄克拉荷马州进行培训和交叉培训[营养和脑功能研究];在阿瓦萨对脑功能研究工具进行试点测试;试验性营养研究，包括：膳食、生物标志物和人体测量学评估;评估该特定人群的锌营养状况、锌吸收和锌需求;第二次计划会议，审查R 01提案的进展和计划细节;最后，根据从R21支持的预备/试验研究中获得的经验和知识，制定R 01提案。