ESTIMATING HUMAN ZINC PHYSIOLOGICAL ZINC REQUIREMENTS: TESTING A NEW CONCEPT

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。食品和营养委员会最近采用了一种本质上是人体如何调节锌的新概念，导致对膳食锌需求量的估计大幅增加。这项建议的长期目标是实现人类锌需要量的准确计算--估计的平均个人膳食需要量(EAR)和推荐膳食摄入量(RDA)。这项建议将专门研究影响全身锌稳态的各种因素之间的相互关系，并特别研究从饮食中吸收的锌量与从粪便和尿液中排出的锌量之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Food and Nutrition Board recently adopted what was essentially a new concept of how the human body regulates zinc that resulted in a very major increase in estimates of dietary zinc requirements. The long-term goal of this proposal is to achieve accurate calculations of human zinc requirements - estimated average individual dietary requirements (EARs) and recommended dietary allowances (RDAs). This proposal will specifically examine the interrelationships between various factors affecting whole body zinc homeostasis, and will particularly examine the relationship between the amount of zinc absorbed from the diet and the amount of zinc eliminated in feces and urine.