Mechanisms of Virus Replication and Gene Expression

描述(由申请者提供)：这是本部门的新项目。马里兰大学细胞生物学和分子遗传学研究所包括来自马里兰大学生物技术研究所农业生物技术中心、弗吉尼亚-马里兰地区兽医学院、国家卫生研究院和美国农业部贝尔茨维尔农业研究服务中心的教职员工。前三所学校位于马里兰大学的学院公园校区，后两所学校分别相距14英里和4英里。通过与附近机构的教员相结合，我们组建了一支在病毒复制/基因表达和疫苗开发方面具有共同研究兴趣的特殊教员团队。广泛的实验系统，从最小的病原体(普恩和类病毒)到大型痘病毒，包括单链RNA(正义和负义)病毒：dsRNA和dsDNA病毒，以及植物、真菌和动物宿主，为我们提供了一个在研究生和博士后水平提供研究培训的机会，这是任何其他机构都无法比拟的。大多数病毒学课程要么集中在医学院，专注于动物病毒，要么集中在植物病理系，专注于植物病毒。然而，无论宿主是什么，细胞内的病毒过程都惊人地相似。为了全面了解细胞内病毒的生命周期，这是开发下一代病毒疫苗和基于病毒的基因表达系统所必需的，学生必须学会欣赏和融合病毒/细胞相互作用的所有知识。通过创新的轮换、每月的小组会议和高级团队授课课程，受训人员将获得这样的实用知识，为以抗击威胁人类健康的现有和新兴病毒为中心的研究生涯做好准备。培训计划的核心是13名资金雄厚、研究和培训记录可靠的调查人员，他们目前通过参加每月的小组会议和年度务虚会进行互动。拟议的计划将为五名研究生和五名博士后研究员提供经济支持。新的研究生将由一个教员团队指导，他们将帮助学生在马里兰大学校园内外开展研究。细胞生物学和分子遗传学系是所有研究生实习生的附属系，在吸引少数族裔、身体残疾和女性学生方面有着不同寻常的记录。还设计了一项创新计划，以帮助吸引更多代表不足的学生参加培训计划。

DESCRIPTION (provided by applicant): This new program from the Dept. of Cell Biology and Molecular Genetics at the University of Maryland includes faculty from the Center for Agricultural Biotechnology at the University of Maryland Biotechnology Institute, the Virginia-Maryland Regional College of Veterinary Medicine, the National Institutes of Health, and the Beltsville Agricultural Research Service of the USDA. The first three institutions are located on the College Park campus of the University of Maryland, while the latter two are 14 and 4 miles distant, respectively. By combining with faculty at nearby institutions, we have assembled an exceptional group of faculty with common research interests in virus replication/gene expression and vaccine development. The breadth of experimental systems, from the smallest pathogenic agents (prions and viroids) to the large poxviruses, comprising ssRNA (plus- and minus-sense) viruses: dsRNA and dsDNA viruses, and plant, fungus, and animal hosts, provide us with an opportunity to offer research training at the graduate and postdoctoral levels that is unmatched by any other institution. Most virology programs are centered either at medical schools, which focus on animal viruses or at plant pathology departments, which concentrate on plant viruses. However, viral processes inside cells are strikingly similar regardless of host. To gain a complete understanding of the intracellular virus life-cycle, which is required for the development of the next generation of virus vaccines and virus-based gene expression systems, students must learn to appreciate and incorporate all knowledge of virus/cell interactions. Through innovative rotations, monthly group meetings, and advanced team-taught classes, trainees will gain such a functional knowledge that will prepare them for research careers centered on combating current and emerging viruses that threaten human health. At the core of the training program are 13 well-funded investigators with proven research and training records, who currently interact by attending monthly group meetings and a yearly retreat. The proposed program will provide financial support for five graduate students and five postdoctoral fellows. New graduate students will be mentored by a team of faculty who will aid the students in the logistics of conducting research both on and off the University of Maryland campus. The Department of Cell Biology and Molecular Genetics, with which all graduate trainees will be affiliated, has an exceptional record at attracting minority, physically disadvantaged, and women students. An innovative program has also been designed to help attract additional underrepresented students to the training program.